DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and si:dkey-206f10.1

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	XP_009293230.1	Gene:	si:dkey-206f10.1 / 560719	ZFINID:	ZDB-GENE-041014-154	Length:	1187	Species:	Danio rerio

Alignment Length:	1650	Identity:	381/1650 - (23%)
Similarity:	573/1650 - (34%)	Gaps:	650/1650 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 FDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSL---MWCLYFVVDGGSEDFWRPISSSFSMLSL 135
            |.|..||:.||.. ..|.| |....::.|:..:.   ::.||..:.....|.   :.|.|:...:
Zfish   139 FKSKDLEKLYQRH-SSHTR-RTSLVVTNIIDAAAKLHLFLLYLALAPDRSDI---LMSWFTGFFM 198

  Fly   136 VTIMALCFTHWDLYREHRTVTSAVTALLLCGASLAFLTYTGRA------FSPLGHFAICLE---- 190
            ...:|||.......|.|               |..:|.|.|.|      ...||..|..||
Zfish   199 ACAIALCVLVLTCKRSH---------------SPKWLHYAGMASWLSQTAQVLGGLAYGLERDQS 248

  Fly   191 -----IVLLIYTALPMP-LW-LGASTAIS-YSIAFEMVSHM-VIGCSAIHGGPMHGGGGAAGGSG 246
                 .:...||.||:| || :||.|..| ..:..|.:.|: .:|..
Zfish   249 WYVLFTLFATYTLLPLPLLWAIGAGTLTSILHLTAETIRHISEVGLF------------------ 295

  Fly   247 MEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMI 311
                     |.|:.:.:.:.|:::.|:.:..:.....|..|::..:.:..|.:||.|.|.:|:::
Zfish   296 ---------RKLLAKALLYTSMNVAGLFIHYLTDRSQRQAFLETRRCIEGRMKLETENQRQERLV 351

  Fly   312 HSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVG 376
            .|::|..||..::::  .:.:| ..|.|:.              |...::|..::||||||||.|
Zfish   352 LSILPRFVALEMISD--MTSMD-DELDPQQ--------------FHKVYIHQYKDVSILFADIKG 399

  Fly   377 FTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGL 441
            ||.:|...:|::||.:||:||.|||.|.....|.:|..||||||||||.|||:..||.|||||||
Zfish   400 FTLLSMNMSAQELVRLLNELFGRFDRLAEEYDCLRIKILGDCYYCVSGVPEPQRAHARCCVEMGL 464

  Fly   442 GMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHIS 506
            .||..||....|::..:.||:|:|||:||||::|.::.:|||||.||.:||.:|:.|.|.::|||
Zfish   465 AMISTMRSLRKQQNFDMDMRIGIHTGSVLCGVLGLQKWQFDVWSWDVGIANMLEAGGIPGRIHIS 529

  Fly   507 QETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQ 571
            :.|...|..::..|:|      |.|    .|.:|.|.:::...:
Zfish   530 RATLDCLDGSFQTEDG------RGY----ERNEFLRKHNIDTFL--------------------- 563

  Fly   572 SATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAA 636
                                                                      |.|
Zfish   564 ----------------------------------------------------------ICH---- 566

  Fly   637 GIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKR 701
                                                                            :
Zfish   567 ----------------------------------------------------------------K 567

  Fly   702 FEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLP 766
            .:||                .|.|.|..|.:   |.:...|.|...:|     .||:   |.|||
Zfish   568 EDDL----------------NEMEAEHPKTR---HNNRPWNKEILASF-----SNGS---YTQLP 605

  Fly   767 VLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRS 831
                                          .||..||....::           ...:..||:||
Zfish   606 ------------------------------TSSACRSMSKEIN-----------KRIEHAIDLRS 629

  Fly   832 YISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRAST 896

Zfish   630 ----------------------------------------------------------------- 629

  Fly   897 LATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRS 961
                                                 ....||..|.|.....||:.|:  .:.|
Zfish   630 -------------------------------------SERMRQEHITPVTLVFKDAHIE--EKFS 655

  Fly   962 SIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLA 1026
            .::.:::..|...              |.|..|       |.:|||    .|:|.....:...|.
Zfish   656 QVRDEMFKTNLVC--------------SFIMLL-------LLMAVQ----ALIPVPRMYLWTVLQ 695

  Fly  1027 ACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEG 1091
            .||..|                    .||:   |....|                   ||.....
Zfish   696 FCLFLL--------------------GYLL---LLVMVL-------------------AEEFKHS 718

  Fly  1092 PPTLATPRYNTYIDIFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQV-FALFLFTR 1155
            |                |:....|..:.     :|.   |.|..:|:    |.|.: |.:.||..
Zfish   719 P----------------GVLQQFCCWIH-----ENN---SMRNLLTI----TAIAMNFGMALFDM 755

  Fly  1156 QMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLM 1220
            ..|.       |:..:..||      |:..|...|.:| ..:|.          ||....|:.::
Zfish   756 MWCN-------SSEMKEIST------RETEGYKAGQKP-LTACT----------YPEVFVLSGVV 796

  Fly  1221 AM---PVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGI 1282
            :|   .|.|.:::.|.|                                  .:|.|:.|:....|
Zfish   797 SMVTCAVFLRMSSLLKL----------------------------------TILLFVVAVYTYFI 827

  Fly  1283 AVSQLMVYSHNRSDQQQDQE---ASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRL 1344
            .||..|:|.|     ||:.|   .|:|::.      ..|.|.| :.:.::.|.:..|.:|...||
Zfish   828 EVSFHMLYVH-----QQEHEHLSRSHFLRR------KGVSILL-MAMFMIAVLYNGRRWEATTRL 880

  Fly  1345 TFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHL----KNTAK-YSENHHNIAIIFASIVN 1404
            .|.....|.|:...:::::...:.|||||:|.|||.|.    :|..: ||:::..:.::||||..
Zfish   881 DFLWRLQAQQEVQEMRDLREHNECLLHNILPAHVARHFLERNRNDQELYSQSYDEVGVMFASIAG 945

  Fly  1405 FNEMYDESYL--GGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDP--SHRGT 1465
            ||:.|::..:  .|.|.|::|||:|.||||||....|..:||||||||.:||||||.|  ..|..
Zfish   946 FNDYYEQKEIKHEGVECLKLLNEIIADFDELLEESYFLDIEKIKTIGSCYMAASGLSPDKQSRVV 1010

  Fly  1466 GD-EHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVA 1529
            .| .|:..|:.|::||||.:...||..:. |..||:|:..|.|.|||||.:|..|||||..||:|
Zfish  1011 NDWHHLSELVLFALAMQETLREINKHSMN-NFQLRVGIAHGPVVAGVIGATKPQYDIWGMTVNLA 1074

  Fly  1530 SRMDSTGLPNRIQVGKDCLPFLTN-RYEFEPRGSVYVKG----KDHMEVFLYTTRRDNPLDDDEA 1589
            |||||||:..||||.:.....|.: .:..|.||.:|:||    |..:..:..:|:|.....:..|
Zfish  1075 SRMDSTGVSGRIQVPEATRNILADWGFVLELRGEIYIKGVSERKGRVRTYFISTKRRLVSSNGIA 1139

  Fly  1590 DKVEQLGTKKMEHEGRD--EDVVQGEQQAEDKDEEEEEEEEDDDLHSSETTTLFKSQESLQANGG 1652
            |:      .|..|.||.  ..||.|..||..::::.                        ..|||
Zfish  1140 DR------GKNGHTGRTTLAAVVFGLVQAIHREKQR------------------------GTNGG 1174

  Fly  1653 SHLAPNAAATSHTHTITLTNNNNHN 1677
                           .||||:|..|
Zfish  1175 ---------------FTLTNSNFSN 1184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	92/215 (43%)
		Guanylate_cyc	361..535	CDD:278633	85/173 (49%)
		CYCc	1362..1556	CDD:214485	92/204 (45%)
		Guanylate_cyc	1388..1575	CDD:278633	88/196 (45%)
si:dkey-206f10.1	XP_009293230.1	AC_N	<135..380	CDD:292831	63/304 (21%)
		CYCc	343..538	CDD:214485	92/211 (44%)
		Guanylate_cyc	382..564	CDD:278633	88/270 (33%)
		DUF1053	<611..661	CDD:283888	14/164 (9%)
		CYCc	899..1097	CDD:214485	91/198 (46%)
		Guanylate_cyc	928..1126	CDD:278633	88/198 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810