DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and npr1a

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001038402.1	Gene:	npr1a / 560653	ZFINID:	ZDB-GENE-060503-539	Length:	1067	Species:	Danio rerio

Alignment Length:	280	Identity:	79/280 - (28%)
Similarity:	142/280 - (50%)	Gaps:	51/280 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 GVHVLIMNLVRMRGTFMKVGQNL--LVRRQLEM---EKQLKEKMIHSVMPPKVADMLLNEGGPSG 331
            |.::|...|.||.    :...||  ||..:.:.   ||:..|.:::.::|..||:.|
Zfish   816 GSNILDNLLSRME----QYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQL-------- 868

  Fly   332 LDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDL 396
                           :....|::       .:.::|:|.|:||||||.:|:..|..::|.:||||
Zfish   869 ---------------KRGEMVQA-------EAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDL 911

  Fly   397 FERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRAD-HAICCVEMGLGMIDAMRCFDAQRHE---G 457
            :..||.:.......|:.|:||.|..|||.|..... ||.....|.|.:::|:..|.. ||.   .
Zfish   912 YTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRI-RHRPNLQ 975

  Fly   458 VKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGD--AYYLE 520
            :::|:|:|:|.|..|:||.:..::.::.:.|:.|::|||:|:..::|:|:.|.:.|.:  .:.||
Zfish   976 LRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLE 1040

  Fly   521 -EGE-EVFGH---RTYFVVG 535
             .|: |:.|.   |||:::|
Zfish  1041 LRGDVEMKGKGRMRTYWLLG 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	61/224 (27%)
		Guanylate_cyc	361..535	CDD:278633	61/184 (33%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
npr1a	NP_001038402.1	PBP1_NPR_A	48..449	CDD:107380
		ANF_receptor	66..421	CDD:279440
		PK_GC-A_B	540..814	CDD:270944
		TyrKc	554..808	CDD:197581
		HNOBA	<823..868	CDD:285003	13/48 (27%)
		CYCc	847..1032	CDD:214485	60/215 (28%)
		Guanylate_cyc	874..1060	CDD:278633	62/193 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900