Protein Alignment Ac13E and si:ch211-132f19.7

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_688903.4
• Gene: si:ch211-132f19.7 / 560410
• ZFINID: ZDB-GENE-130530-619
• Length: 1183
• Species: Danio rerio
• Alignment Length: 1649
• Identity: 366/1649 - (22%)
• Similarity: 561/1649 - (34%)
• Gaps: 662/1649 - (40%)

  Fly    70 LDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLYFVVDGGSEDFWRPISSSFSMLS 134
            |..||.|..||..||    .|...:.|.:|....:..::..|:.:               |..|:
Zfish   130 LHHKFKSHDLEHLYQ----QHSSGQRRTSLVVTNVIDILTKLHII---------------FIYLA 175

  Fly   135 LVTIMALCFTHWDLYREHRTVTSAVTAL--------LLCGASLA--FLTYTGRA------FSPLG 183
            |...|        :..:|..:...:.||        |.|...::  :|.|.|.|      ...||
Zfish   176 LAPEM--------VDSQHGWLAGLLMALGAIICVLVLTCKGLMSPDYLRYAGLASWLSQTVQALG 232

  Fly   184 HFAICLE---------IVLLIYTALPMP-LW---LGASTAISYSIAFEMVSHMVIGCSAIHGGPM 235
            .....||         .:..|||.||:| ||   :|..||         ..|:.:
Zfish   233 GLVYGLETDQSWYVLFTLFAIYTLLPLPLLWSICMGFLTA---------ALHLFV---------- 278

  Fly   236 HGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQL 300
                    .:....|.....|.|:.:.:.::.::..|:.:..::....|..|::..:.:..|.::
Zfish   279 --------DTFKNYNDTAIVRKLLAKGLLYMGMNTAGLFIHYLSDRAQRQAFLETRRCIEGRVKM 335

  Fly   301 EMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSME 365
            |.|.|.:|:::.|::|..:|..::  |..:.||...||.:.|          |:.|     |..:
Zfish   336 ERENQRQERLVMSILPRFIAMEMI--GDMTALDDELLPQQFH----------KTYF-----HQYK 383

  Fly   366 NVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRA 430
            :||||||||.|||.:|.|..|::||..||:||.|||.|...:.|.:|..||||||||||.|||:.
Zfish   384 DVSILFADIKGFTSLSMTMPAQELVRTLNELFGRFDRLAEENHCMRIKILGDCYYCVSGVPEPQT 448

  Fly   431 DHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKME 495
            .||.|||||||.||:.:|....:....:.||:|:|:|:||||::|.::.:|||||.||.:||.:|
Zfish   449 AHARCCVEMGLAMINTIRYVRKELKRDMDMRIGIHSGSVLCGVLGLQKWQFDVWSWDVDVANMLE 513

  Fly   496 SSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLL 560
            :.|.|.::|||:.|...|...|..|||.   ||       .|.:|.|.:.:.
Zfish   514 AGGIPGRIHISRATLDCLEGVYETEEGR---GH-------ERNEFLRKHKID------------- 555

  Fly   561 LPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRD 625
                                                                             
Zfish   556 ----------------------------------------------------------------- 555

  Fly   626 VERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKL 690
                           ..::|..|:            |..|             ||.....||.:
Zfish   556 ---------------TFLIRHTPQ------------DDKE-------------PPKVRRTSKDE- 579

  Fly   691 KVW--KIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQ 753
            ..|  ::|     |:::...:....:.:.|.|              :|..||:.|
Zfish   580 TTWSAELP-----FDNIIGMNCILATFTNGSL--------------VHLPNQITP---------- 615

  Fly   754 MQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPG 818
                                               |.|.|..:...:.::
Zfish   616 -----------------------------------HCAGSREINKRIKQA--------------- 630

  Fly   819 QYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPP 883
                    |:|||.....:..|:||
Zfish   631 --------IEVRSSERMRKEHITPF---------------------------------------- 647

  Fly   884 VEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATS 948
                        ||                                 :|..||     |....:.
Zfish   648 ------------TL---------------------------------VFKDTH-----IEGKFSQ 662

  Fly   949 RKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLL 1013
            .:|...|||...|.:........|..|                                 |.|..
Zfish   663 MRDEMFKSNLACSFLLLLFIMAAQALI---------------------------------PSPQF 694

  Fly  1014 MPACSS-------QMADPLAACLQQLRKQSD-LQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSR 1070
            .|....       .|...|....::.::... ||.:.|.....:|.|:.|
Zfish   695 FPMIIQFLVFLFVYMLVLLVTLAEEFKRSPPYLQHLCCWIHETKSIRNLL--------------- 744

  Fly  1071 QLERDFRSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAVYLCISVSLFLMTQNTVSPSFRLW 1135
                                   ||      |.|.|..|:|     |.::|             |
Zfish   745 -----------------------TL------TAIAINFGVA-----SCNIF-------------W 762

  Fly  1136 VTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCAD 1200
                                  |               :.|.|:.|:..:.:..|
Zfish   763 ----------------------C---------------NGTFEETEKSNKNSEHG---------- 780

  Fly  1201 RIFEAISSWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNC 1265
                  ..| |.:||     ..|...:::..:.:                ..|.|    |.:|:|
Zfish   781 ------KQW-PVNIC-----THPEFFVLSGVVAM----------------VTCAV----FLRLSC 813

  Fly  1266 WVR-NVLAFLAAL--CFIGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLI 1327
            .:: .||..:.|:  ..|.:|...|.:..|..|.          ||..::.:...:.:.| :.:.
Zfish   814 LLKLAVLTLVIAVYTYLIEVAFHVLFIRQHQNSQ----------IQRSQYLRRKGISVLL-MAMF 867

  Fly  1328 LVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHL-----KNTAK 1387
            :|:|.:.:|:.|...||.|.....|.|:...::.::...:.||:||:|.|||.|.     .|...
Zfish   868 VVVVLYNSRQLETTSRLDFLWRLQARQEVEDMKELREHNECLLYNILPAHVARHFLERDRNNEDL 932

  Fly  1388 YSENHHNIAIIFASIVNFNEMYDESYL--GGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGS 1450
            :||::..:.::||||..|::.|::..|  ...|.||:|||:|.||||||..|.|:.:||||||||
Zfish   933 FSESYERVGVMFASIPGFSDYYEKKELIHQDVECLRLLNEIIADFDELLDEPYFQDIEKIKTIGS 997

  Fly  1451 TFMAASGLDPSHRGTGDE--HIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIG 1513
            .:||||||.|..:...||  |:.||:.|::||||.:...||.... :..||:|::.|.|.|||||
Zfish   998 CYMAASGLSPEKQECEDEWAHLSTLVLFALAMQETLKEINKRTSN-DFWLRVGISHGPVVAGVIG 1061

  Fly  1514 TSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNR------YEFEPRGSVYVKG----K 1568
            .:|..|||||..||:|||||||||..||||     |..|:|      :..:.||.:||||    :
Zfish  1062 ATKPQYDIWGMTVNLASRMDSTGLSGRIQV-----PEATSRVLAEHGFMLQLRGEIYVKGVSERR 1121

  Fly  1569 DHMEVFLYTTRRDNPLDDDEADKVEQLGTKKMEHEGRD--EDVVQGEQQAEDKDEEEEEEEEDDD 1631
            ..:..:..::|..|       ....:..|.:....||:  ..||....||..|:|..|
Zfish  1122 GAVRTYFVSSREHN-------SSYAERNTSRGISLGRNTLAAVVFSLVQARKKEELRE------- 1172

  Fly  1632 LHSSETTTLFKSQESLQANGGSHL 1655
                             ||||.||
Zfish  1173 -----------------ANGGFHL 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	93/215 (43%)
		PHA03307	836..>1015	CDD:223039	18/178 (10%)
		Guanylate_cyc	1388..1575	CDD:425528	91/200 (46%)
si:ch211-132f19.7	XP_688903.4	AcyC	162..539	CDD:441717	132/443 (30%)
		Guanylate_cyc	378..559	CDD:425528	89/288 (31%)
		Adcy_cons_dom	579..668	CDD:461877	26/266 (10%)
		Guanylate_cyc	932..1131	CDD:425528	91/204 (45%)