Protein Alignment Ac13E and adcy2b

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_005170095.1
• Gene: adcy2b / 557902
• ZFINID: ZDB-GENE-060503-69
• Length: 1142
• Species: Danio rerio
• Alignment Length: 1608
• Identity: 357/1608 - (22%)
• Similarity: 566/1608 - (35%)
• Gaps: 653/1608 - (40%)

  Fly    53 CSVMLPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLYFVVDG 117
            |..:|.|.|     .|.||        .|::.|.:     |....||:..|...::.|:
Zfish   105 CLALLAVFF-----ASGLD--------MEEHMAFI-----MTVPTTLAIFLAIFILVCI------ 145

  Fly   118 GSEDFWRPISSSFSMLSLVTIMALCFTHWDLYREHRTVTSAVTALLLCGASLAFL-TYTGRAFSP 181
              |..::.:...||:|.           |.                 |..::.:| .:.|....|
Zfish   146 --ESVFKKLLRLFSLLI-----------WG-----------------CLVAMGYLFMFFGGIICP 180

  Fly   182 LGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSG 246
            ....:..|.||.::||.||..:......::..|.:..:|..:.:..::.|
Zfish   181 WDQVSFFLFIVFVVYTMLPFSMRDAVIASVLTSSSHTLVLSICLSNTSDH--------------- 230

  Fly   247 MEANGDPSNRILILRIMAHLSVHLVG-----VHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQL 306
            |||        |:.:|:|::.:.:.|     .|..:|:|. ::.|:......:....:||.||..
Zfish   231 MEA--------LVWQILANIIIFICGNVAGAYHKHLMDLA-LKQTYHDTCNCIKSPIKLEFEKHQ 286

  Fly   307 KEKMIHSVMPPKVADMLLNE-----GGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMEN 366
            :|:::.|::|..:|.::..|     .||            ::.:...:|:..:|:...|    .|
Zfish   287 QERLLLSLLPAHIARVMKAEIIQRLKGP------------NFSQAENTNNFHNLYVQRH----TN 335

  Fly   367 VSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRAD 431
            ||||:||||||||::|..:..:||.:||:||.:||.:...:.|.:|..||||||||||.|:|..|
Zfish   336 VSILYADIVGFTRLASDCSPGELVYMLNELFGKFDQIAKDNDCMRIKILGDCYYCVSGLPDPLLD 400

  Fly   432 HAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMES 496
            ||..||:|||.|.:|:..........:.||||||:|.||||::|.::.::||||:||:|||.||:
Zfish   401 HAKNCVKMGLDMCEAIEKVREATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEA 465

  Fly   497 SGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLL 561
            .|.|.:||||..|...|..||.:|:|.           |:.||                  |.|
Zfish   466 GGVPGRVHISSVTLEHLNGAYKVEQGN-----------GQSRD------------------SYL- 500

  Fly   562 PGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDV 626
             ..||      ......:.|.....||:  |.|::.|          |....|||
Zfish   501 -KEHG------IVTYLVINPKAEKRSPL--LLSAIRP----------TMYGAKMR---------- 536

  Fly   627 ERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLK 691
                                                                   |..|....|:
Zfish   537 -------------------------------------------------------ASVRMTQYLE 546

  Fly   692 VWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQN 756
            .|..   .|.|.:|.:|.|                                           |.|
Zfish   547 SWGA---AKPFANLHHRDS-------------------------------------------MTN 565

  Fly   757 GNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYS 821
            .||              ...|.|:|.                                   |||:
Zfish   566 ENG--------------MINTRDVPL-----------------------------------GQYN 581

  Fly   822 MYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQ 886
                        .|.||:
Zfish   582 ------------CQQRSE----------------------------------------------- 587

  Fly   887 SPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKD 951
                                                                             
Zfish   588 ----------------------------------------------------------------- 587

  Fly   952 SGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPA 1016
               ::.|::...:::   ||:
Zfish   588 ---RTKSQKKRFEEE---LNE-------------------------------------------- 602

  Fly  1017 CSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAH 1081
                                  ::||.: |...||:.:|....:::.||:|.::.||:::|:
Zfish   603 ----------------------RIIRTI-DGINSQKQWLKSEDIQRISLFFHNKALEKEYRA--- 641

  Fly  1082 RFGAENETEGPPTLATPRYNTYIDIFVGIAVYLCI-SVSLFLMTQNTV-SPSFRLWVTLFS---- 1140
                       .||  |.:..|:.  ....::.|| .|.:.::.:.|| ..||.:...|.:
Zfish   642 -----------TTL--PAFKYYVT--CACLIFFCIFIVQVLVLPKTTVLEVSFGMAFLLLALILC 691

  Fly  1141 -CFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFE 1204
             ||.|                    ::....::.|.|               .|...|.:..|..
Zfish   692 ICFAG--------------------HILQWGKAASCT---------------MPRLPSSSKVITN 721

  Fly  1205 AISSWYPWHICLAVLMAMPVLLIIA---NFLLLDLEQLEAF-----------------------E 1243
            .     || |.||:.||...|:::.   |...|..:::.|.                       :
Zfish   722 K-----PW-IRLALTMATTALILVMAVFNMFFLGEDRMVASTSLNISNSSMDGPYGQITNSSNNK 780

  Fly  1244 YHYGFLIFVCIVHF--CN-FTQLNCWVRNVLAFLAALCFIGIAVSQ----------LMVYSHNRS 1295
            ::..:.|:.||:..  |: |.::|..::.:: .|.|:....|.:.|          :.:|    .
Zfish   781 FYLPYFIYSCILGLISCSVFLRINYELKMII-MLGAVVAYNIIILQTHASILDDYSMALY----K 840

  Fly  1296 DQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQ 1360
            .||.|:  ...::::|......:.|:...||:|.      |:.|...||.|.......::...::
Zfish   841 TQQPDR--PGVLKDLKTMGSISLFIFFVTLLVLA------RQNEYYCRLDFLWRNKFKKECEEIE 897

  Fly  1361 NMKNQADMLLHNIIPKHVAEHL-----KNTAKYSENHHNIAIIFASIVNFNEMYDESYLG--GKE 1418
            .|:|...:||.|::|.|||||.     ||...|.:::..:.::||||.:|.|.|.||.:.  |.|
Zfish   898 TMENLNRVLLENVLPAHVAEHFLGRNWKNEDLYHQSYDTVCVMFASIPDFKEFYTESDVNKEGLE 962

  Fly  1419 FLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGDE----------HIHTL 1473
            .||:|||:|.|||||||:|:|..||||||||||:|||:||:.:   .|.|          ||.|:
Zfish   963 CLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNVT---PGLEYAQYHDRQYMHIGTM 1024

  Fly  1474 MEFSIAMQEVVDAFNKDLLEFN-LILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGL 1537
            :||:.|:...:|..||.  .|| ..:|:|:|.|.|.|||||..|..|||||:.|||||||:|||:
Zfish  1025 VEFAFALVGKLDVINKH--SFNDFRMRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMESTGV 1087

  Fly  1538 PNRIQVGKDCLPFL-TNRYEFEPRGSVYVKGKDHMEVFLYTTRRDNPL 1584
            ..:|||.::....| |..|....||.:.||||..:..|...|.....|
Zfish  1088 LGKIQVTEETNWILQTLGYMCSCRGIINVKGKGDLRTFFVHTEMTQSL 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	90/220 (41%)
		PHA03307	836..>1015	CDD:223039	5/178 (3%)
		Guanylate_cyc	1388..1575	CDD:425528	93/200 (47%)
adcy2b	XP_005170095.1	AcyC	97..516	CDD:441717	147/541 (27%)
		Guanylate_cyc	328..512	CDD:425528	90/224 (40%)
		Adcy_cons_dom	542..647	CDD:461877	38/412 (9%)
		Guanylate_cyc	929..1128	CDD:425528	94/203 (46%)