DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and gucy1b2

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	XP_685297.5	Gene:	gucy1b2 / 557191	ZFINID:	ZDB-GENE-130530-664	Length:	757	Species:	Danio rerio

Alignment Length:	286	Identity:	85/286 - (29%)
Similarity:	142/286 - (49%)	Gaps:	44/286 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 MAHLSVHLVGVHVLIMNLVRMRGTFM------KVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVAD 321
            :|.::.|.....::::|..|:....:      |..:..::.|.||:|||..||::::::|..||:
Zfish   387 LADIAQHDTTRDLILLNQQRLAEIELSNQLERKKEELRILSRNLEIEKQKSEKLLYAMLPTHVAN 451

  Fly   322 MLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTA 386
            . |.||  ..::||                           ..:..:|||:|:|.||.:.:....
Zfish   452 Q-LKEG--KRVEAG---------------------------EFKVCTILFSDVVTFTNICAACEP 486

  Fly   387 EQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGM-IDAMRCF 450
            .|:|.:||.::.|||.|.|:....|:.|:||.|..|.|.|.|...||.......||| |.|....
Zfish   487 IQIVNMLNAMYSRFDRLTSIHNVYKVETIGDAYMVVGGVPVPTNTHAERVANFALGMRIAAREVT 551

  Fly   451 DAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGD 515
            :....:.:::|||:|||.||.|:||.:..::.::.:.|:.|::|||.|.|:.:|:|..|.|.:.|
Zfish   552 NPITGQPIQIRVGLHTGPVLAGVVGEKMPRYCLFGDTVNTASRMESHGVPDHIHVSPFTFSVIKD 616

  Fly   516 AYYLEEGE----EVFGH---RTYFVV 534
            ....|..|    ||.|.   ||||::
Zfish   617 KGIFEMAERGEIEVKGKGLMRTYFLL 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	68/216 (31%)
		Guanylate_cyc	361..535	CDD:278633	64/182 (35%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
gucy1b2	XP_685297.5	HNOB	2..163	CDD:285002
		CAF-1_p150	<166..277	CDD:288454
		HNOBA	269..453	CDD:285003	16/66 (24%)
		CYCc	432..618	CDD:214485	68/215 (32%)
		Guanylate_cyc	459..642	CDD:278633	66/209 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810