Protein Alignment Ac13E and adcy1a

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_001161821.1
• Gene: adcy1a / 557026
• ZFINID: ZDB-GENE-070705-302
• Length: 1114
• Species: Danio rerio
• Alignment Length: 1719
• Identity: 371/1719 - (21%)
• Similarity: 569/1719 - (33%)
• Gaps: 722/1719 - (42%)

  Fly    45 QTGRRHSCCSVMLPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFT---LSYILLCS 106
            :|.||.|.|   |..|.||         .||...||..:|..   ::::....|   |:.::|.:
Zfish    15 RTRRRKSRC---LAGACER---------DFDCKELETLFQKY---NLKLEQTATLKALAILILAA 64

  Fly   107 LMWCLY--------FVVDGGSEDFWRPISS-SFSMLSLVT-IMALCFTHWDLYREHRTVTSAVTA 161
            ....|.        |.|..||    .|:.. .|:.|.:|| :..|..|..........:.|...|
Zfish    65 SALALVELLSAGSRFTVSKGS----HPVHCVIFTSLFIVTNVKYLQVTQLQQIARLALLFSFTFA 125

  Fly   162 LLLCGASLAFLTYTGRAFSP--------LGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFE 218
            ||.|...||....|.....|        .|.:.:.| :..:.|:.||:...|    |:.:.: ..
Zfish   126 LLCCPFPLALGHGTQGTHGPDAPSTTPEQGVWQLML-VTFVAYSLLPVRTLL----AVLFGV-LV 184

  Fly   219 MVSHMVIGCSAIHG------GPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLI 277
            ..||.::..:::..      .|:                 .:|.:|:      :.|:|.||.|.:
Zfish   185 AASHFIVTATSVTARRPRVWTPL-----------------VANAVLL------VGVNLSGVFVRV 226

  Fly   278 MNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVA-----DMLLNEGGPSGLDAGGL 337
            ......|..|::....:..|.|||.|.:.:|:::.|::|..||     |.|             .
Zfish   227 RTERAQRKAFLQARNCIQQRLQLEDENEKQERLLMSLLPRNVAMEMKEDFL-------------K 278

  Fly   338 PPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDD 402
            |||             .:|...::...:|||||||||||||.::|..||::||::||:||.:||:
Zfish   279 PPE-------------RIFHKIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDE 330

  Fly   403 LCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTG 467
            |.:.:.|.:|..||||||||||..:|:||||.|||||||.|||.:..........:.||||:|||
Zfish   331 LATENHCRRIKILGDCYYCVSGLTQPKADHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTG 395

  Fly   468 TVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYF 532
            .||||::|.|:.::|||||||:|||.||:.|.|.:|||::.|...|...|.:|.|   |||..:
Zfish   396 RVLCGVLGLRKWQYDVWSNDVTLANMMEAGGLPGKVHITKATLECLNGDYEVEPG---FGHERH- 456

  Fly   533 VVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLN 597
                                              |.||:.|.....:.|:
Zfish   457 ----------------------------------AFLSKHAIETFFIVPS--------------- 472

  Fly   598 PSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLD 662
                                                            .|.||      .||.:.
Zfish   473 ------------------------------------------------HRRKI------FPGLIL 483

  Fly   663 SDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKERERE 727
            ||         :.||.....:|...:.:::....:..|.....:|..:|.        |.::.|.
Zfish   484 SD---------IKPAKRMEFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCE--------DDDKRRA 531

  Fly   728 REKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAAT 792
            .....|:|....        :|....:||
Zfish   532 LRTASEKLRNRT--------SFSAGMVQN------------------------------------ 552

  Fly   793 STALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQS 857
                                   |||        ..|..||
Zfish   553 -----------------------SPG--------TRVNRYI------------------------ 562

  Fly   858 TGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAP 922
                           ||                      |...|.|
Zfish   563 ---------------GR----------------------LIEARQT------------------- 571

  Fly   923 GNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSS 987
                                                                             
Zfish   572 ----------------------------------------------------------------- 571

  Fly   988 TSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQR 1052
                                          .|:|||
Zfish   572 ------------------------------ESEMAD----------------------------- 577

  Fly  1053 SYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLATPRY-NTYIDIFVGIAVYLCI 1116
                   |...:|.::||:.|:                        || ..|.|.|:...|...:
Zfish   578 -------LNYITLTYRSREREQ------------------------RYLQVYDDAFISAVVISLV 611

  Fly  1117 SVSLFLMTQNTVSPSFRLWVTLF---SCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSE 1178
            ..|.|.:....:.|...|.|.|.   .||....|..|.: |...|                  |.
Zfish   612 LTSFFAVVYFLIIPQGLLVVILLVLCLCFHMASVMYLHV-THVQC------------------SP 657

  Fly  1179 DLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEAFE 1243
            |                                   ||    .:.:..::..||:|.:     :.
Zfish   658 D-----------------------------------CL----TLQIRTVLCGFLVLLM-----YS 678

  Fly  1244 YHYGFLIFVCI------------------------VHFCNFTQ---LNCWVRNVLAFLAALCFIG 1281
            ...|.:: .|:                        ...|.:|.   |:|    |:|.|:...::.
Zfish   679 VTQGCVV-TCVPWSLEGNSSISMVTVVTVNGTGVGYRVCKYTPYVFLSC----VMASLSVALYLR 738

  Fly  1282 IA------VSQLMVYSHNRSDQQQDQEASNFIQEI--KWFQDYHVEIYLDLLLILVLVWFLNREF 1338
            ::      :..|:...|.     ...|.|.:.:.:  .:|..:..:..|.:||....:....|:.
Zfish   739 VSSLPKILLLLLLNILHT-----VVMETSGYRKAVGGGFFHTHGYDPVLAMLLFSGALVLHCRQL 798

  Fly  1339 EIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHL-----KNTAKYSENHHNIAII 1398
            ::..||.:.....|.:::..::.:|.....:|.|::|.|||:|.     :|...|.:::..:.::
Zfish   799 DLKLRLDYLWATQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLLSNPRNMDLYYQSYSQVGVL 863

  Fly  1399 FASIVNFNEMYDESYLGGK----EFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLD 1459
            ||||.|||:.|.|  |.|.    |.||:|||:|.|||.|:.:..:|.:|||||||||:|||.||.
Zfish   864 FASIPNFNDFYIE--LDGNNMGVECLRLLNEIIADFDALMDKECYRDIEKIKTIGSTYMAAVGLV 926

  Fly  1460 PSH----RGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFN-LILRIGMNIGDVTAGVIGTSKLYY 1519
            |:.    :.:...|:.|:.:::|.|.:|:||.|..  .:| .:||:|:|:|.|.|||||..:..|
Zfish   927 PTEGSKVKKSISAHLCTVADYAIEMFDVLDAINYQ--SYNDFVLRVGINVGPVVAGVIGARRPQY 989

  Fly  1520 DIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNRYEFEPRGSVYVKGKDHMEVFLYTTRRDNPL 1584
            ||||:.|||||||||||:..:|||.:|....|:..|:|..||.|.||||..|..:..
Zfish   990 DIWGNTVNVASRMDSTGVQGKIQVTEDVFRLLSGYYDFNCRGQVSVKGKGQMLTYFL-------- 1046

  Fly  1585 DDDEADKVEQLGTKKMEHEGRDEDVVQGEQQAEDKDEEEEEEEEDDDLHSSETTTLFKSQESLQA 1649
                              |||   ..||.|.:..|..:::                  |...::.
Zfish  1047 ------------------EGR---TPQGAQHSRSKSPDQD------------------SSPCIRT 1072

  Fly  1650 NGGSHLAPNAAA---TSHTHTITLTNNNN 1675
            ..||  ||..::   .|||.....|:||:
Zfish  1073 KLGS--APAVSSYGVKSHTVGHVGTSNNS 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	96/220 (44%)
		Guanylate_cyc	361..535	CDD:278633	90/173 (52%)
		CYCc	1362..1556	CDD:214485	89/207 (43%)
		Guanylate_cyc	1388..1575	CDD:278633	90/195 (46%)
adcy1a	NP_001161821.1	AC_N	<154..285	CDD:292831	34/185 (18%)
		CYCc	251..446	CDD:214485	96/220 (44%)
		Guanylate_cyc	287..469	CDD:278633	94/219 (43%)
		DUF1053	513..601	CDD:283888	32/405 (8%)
		CYCc	819..1029	CDD:214485	91/213 (43%)
		Guanylate_cyc	852..1048	CDD:278633	90/225 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810