DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and npr1b

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	XP_009290669.2	Gene:	npr1b / 555911	ZFINID:	ZDB-GENE-100805-4	Length:	1070	Species:	Danio rerio

Alignment Length:	290	Identity:	80/290 - (27%)
Similarity:	143/290 - (49%)	Gaps:	60/290 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 HVLIMNLVRMRGTFMKVGQNLLVRRQ-----------------LEMEKQLKEKMIHSVMPPKVAD 321
            |:.::...:.|.....:..|||.|.:                 || ||:..|.:::.::|..||:
Zfish   807 HISVLLRKQNREHRSNILDNLLSRMEQYANNLEELVEERTQAYLE-EKRKAEALLYQILPHSVAE 870

  Fly   322 MLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTA 386
            .|                       :....|::       .:.::|:|.|:||||||.:|:..|.
Zfish   871 QL-----------------------KRGETVQA-------EAFDSVTIYFSDIVGFTSLSAESTP 905

  Fly   387 EQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRAD-HAICCVEMGLGMIDAMRCF 450
            .|:|.:||||:..||.:.......|:.|:||.|..|||.|..... |......|.|.:::|::.|
Zfish   906 LQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTF 970

  Fly   451 DAQRH---EGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSF 512
            .. ||   |.:|:|:|:|:|.|..|:||.:..::.::.:.|:.:::|||:|:|.::|:|..|.:.
Zfish   971 KI-RHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAV 1034

  Fly   513 LGD--AYYLE-EGE-EVFGH---RTYFVVG 535
            |.:  .:.|| .|: |:.|.   |||:::|
Zfish  1035 LQEFNCFQLELRGDVEMKGKGKMRTYWLLG 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	63/221 (29%)
		Guanylate_cyc	361..535	CDD:278633	63/184 (34%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
npr1b	XP_009290669.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900