Protein Alignment Ac13E and ACXE

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Alignment Length: 1650
• Identity: 329/1650 - (19%)
• Similarity: 545/1650 - (33%)
• Gaps: 677/1650 - (41%)

  Fly    62 ERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILL--------CSLMWCLYFVVDGG 118
            ||.....:|..|.....||.:::   ...:|:...:.|::.:|        |:|   |...::..
  Fly    15 ERMWEPGYLKAKCAELRLESEFR---LYRIRLWKSYLLTFFMLHIFVTSVHCAL---LLATIERR 73

  Fly   119 SEDFWRPISSSFSMLSLVTIMALCFTH-------WDLYREHRTVTSAVTALLLCGASLAFLTYTG 176
            |..::....|....|.|:.::::.|..       |.:|     .:|...:|.|..|.|....|..
  Fly    74 SIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMY-----ASSIFASLTLVFADLTESIYHT 133

  Fly   177 RAFS-PLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGG 240
            .|.| .||.| ....|:.:||..||:....||          .:::.:|.|...::.......|.
  Fly   134 YAHSWILGTF-YDTYIIYMIYMFLPIHFISGA----------VLLALLVSGLYILYFVIFIAQGF 187

  Fly   241 AAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMK----VGQNLLVRRQLE 301
            |...|.:.:.|..|     :.|:.:|.::|||:...:||...:|.:|:.    :.:.:.:|....
  Fly   188 AQFASALFSVGGMS-----VDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARL 247

  Fly   302 MEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESH-----YMRPRASNDVKSLFRPFHM 361
            .||||    :.|::||:::                ||.:..     .|..:..:...::.|...:
  Fly   248 QEKQL----LDSILPPQIS----------------LPLQKDIQGRIVMAKQGIHSWTAMERTMAI 292

  Fly   362 HSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCP 426
            ....:||||:||:|.:|.:::|.|.|.||::|:||:.|||........::|..||||||||:|..
  Fly   293 QIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLS 357

  Fly   427 EPRADHAICCVEMGLGMIDAMRCFDAQRHEG--VKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVS 489
            :|..|||..||.:||.||:  ...:.:...|  :.||:|||:|.:..|::|..:::||:|..||:
  Fly   358 DPDPDHANNCVILGLSMIN--HIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVT 420

  Fly   490 LANKMESSGKPEQVHISQETSSFLG-DAYYLEEG-EEVFGH--------RTYFVVGRRRDFTRTN 544
            :||.:||:|.|..||||..|.:.|. :.:.:|:| ||...|        |:|.:   |:|
  Fly   421 IANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYII---RQD----- 477

  Fly   545 SLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLT 609
                 :..:...|...|...|..||    .|:.| ||         ::|.|.|.|........|.
  Fly   478 -----LHMDDEDSDEFLGDLHSISL----CNMGA-QP---------RISDSANQSLRALFHEELR 523

  Fly   610 SLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLL 674
            ....||                 |.:|..|               |.|.|
  Fly   524 EEFRKM-----------------PVSAFSP---------------KRLLG--------------- 541

  Fly   675 PPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHN 739
                                |.||                 :.|              :|:..|.
  Fly   542 --------------------ICRF-----------------NTG--------------KEVPAHQ 555

  Fly   740 QLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHA---ATSTALASSVL 801
            .||  ..|.|.|                                 |:|..|   .|......|::
  Fly   556 NLN--ICLTFTD---------------------------------PILERAYLKQTDYMYKYSII 585

  Fly   802 RSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGP 866
            .|...|       ||    .:|.:::|.:
  Fly   586 LSASVG-------CS----LVYIELMDTQ------------------------------------ 603

  Fly   867 AGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGI 931
                                                                             
  Fly   604 ----------------------------------------------------------------- 603

  Fly   932 FPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGE 996
                     .||.|.
  Fly   604 ---------MICSSC-------------------------------------------------- 609

  Fly   997 VQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLR 1061
                           .::||                    .:..|:|:               |.
  Fly   610 ---------------FVLPA--------------------SVATIQCI---------------LA 624

  Fly  1062 KFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTYIDIFV---------GIAVYLCIS 1117
            ..:.|.|....         |:|..|         .|.:......|:         .:.:.:||
  Fly   625 LIAWYKKYCWT---------RYGRNN---------VPHHYNGFSCFIFRIHDKILNSLPIRICI- 670

  Fly  1118 VSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLER 1182
             .||||    :|..|.:.:.:.||                                       :|
  Fly   671 -YLFLM----ISSFFVMCLIVMSC---------------------------------------QR 691

  Fly  1183 DERGAAPGGRPHFESC--ADRIF----EAISSWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEA 1241
            :|          ||..  .:|:|    ||...::||              :..|.|.|
  Fly   692 EE----------FEMAYIEERLFHYEQEAHICFHPW--------------VTTNMLSL------- 725

  Fly  1242 FEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQL-MVYSHNRSDQQQDQEASN 1305
                     .:|:..  .|..:...|:..:|.|..|.::.:...|. .|:.|:.:.
  Fly   726 ---------MICLTF--TFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTT--------- 770

  Fly  1306 FIQEIKWFQDYHVEIYLDLLLILV--LVWFL-NREFEIGYRLTFYGNAVANQDKVRVQNMKNQAD 1367
                    ..|....|...|||.:  |:.|: .|:.|...::.|.......:::.......:...
  Fly   771 --------NPYFKSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSII 827

  Fly  1368 MLLHNIIPKHVAE-HLKNTAK---YSENHHNIAIIFASIVNFNEMYDESYLGGKEFLRVLNELIG 1428
            ::|:||:|.|:.: :|.:.||   |.||:..::::||.::|| ||...|       ||||||:|.
  Fly   828 IILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLINF-EMDLRS-------LRVLNEIIA 884

  Fly  1429 DFDE-LLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTG-------------------------- 1466
            :||. ||...|:..|||||.:|.|:|||.|||.:..|:.
  Fly   885 EFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQS 949

  Fly  1467 ----DEHIHTLMEFSIAMQEVV----DAFNKDLLEFNL---ILRIGMNIGDVTAGVIGTSKLYYD 1520
                ||.:..:..:::.|...:    :|:.....:.|:   .:.||::.|:|.||::|.|:.:||
  Fly   950 NEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYD 1014

  Fly  1521 IWGDAVNVASRMDSTGLPNRIQVGKDCLPFL-----TNRYEFEPRGSVYVKGKDHMEVFLYTTRR 1580
            |||:.||:||||:|||||..|.|.::....|     |..|    ||..:|||:..:..:|...
  Fly  1015 IWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSY----RGMTFVKGRGKIPTYLVGI-- 1073

  Fly  1581 DNPLDDDEADKVEQLGTKKMEHEGR 1605
                 |:..:.:.|..|:...|:.|
  Fly  1074 -----DENLNFIPQKATRFPSHQER 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	76/223 (34%)
		PHA03307	836..>1015	CDD:223039	3/178 (2%)
		Guanylate_cyc	1388..1575	CDD:425528	75/229 (33%)
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	120/433 (28%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	69/170 (41%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	75/231 (32%)