DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	504	Identity:	100/504 - (19%)
Similarity:	162/504 - (32%)	Gaps:	149/504 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   670 SPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSC------GGSS-------SAGHLD 721
            |..||....|..|:..|...|.|             .|..:|      ||..       |..|..
  Rat   909 SSALLCYIRPDTADPTSSFSLTV-------------ANVGTCQAVLCRGGKPVPLSKVFSLEHDP 960

  Fly   722 KEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQT-LDIPAARP 785
            :|.:|.:: :|..:.:.|::|.......|       .||.| ..|.::...|.:.| |.|.....
  Rat   961 EEAQRVKD-QKAIITEDNKVNGVTCCTRM-------LGCTY-LYPWILPKPHISSTPLTIQDELL 1016

  Fly   786 VLHHAA----TSTALASSVLRSPEAGVSGGGGCCSPGQ-YSMYDDIIDVRSYISQSRSDISPFGR 845
            :|.:.|    .|...|.|.:|..:..::.....|:..| |...|::..:..|::        .|.
  Rat  1017 ILGNKALWEHLSYLEAVSAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLN--------IGE 1073

  Fly   846 SGSYRSQCGRQSTGGVNGAGPA---------------GVGAE--GRAGTSQTAPPV--------- 884
            .|......|....|.|..|..|               |:.:|  ....||:.:..|
  Rat  1074 EGCTCEMHGLALPGPVGFASTATIKDAPKPTTPSSSSGIASELSSEVSTSEVSSEVGSTASDEHN 1138

  Fly   885 ----EQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPS 945
                |.|.||||....         ||.|.||:                    .|..||.|....
  Rat  1139 TVGLETSLLPRPERRC---------SLHPVPSA--------------------GTFQRQPSCATF 1174

  Fly   946 ATSRKDSGIKS-----------NSRRSSIQQQIYAL----NQTAISQHRVSGYFTSSTSSISNLG 995
            ::::.|:|:.|           |..|..::..|:..    ::.:.:..:.|.|..|..
  Rat  1175 SSNQSDNGLDSDDDQPVEGVITNGSRVEVEVDIHCCRGRESENSPTLPKNSSYPCSEE------- 1232

  Fly   996 EVQGLGLPLAVQPP--PPLLMPACSSQM---ADPLAACL--QQLRK------QSDLQLIRCVRDN 1047
            ..:|||..:..|..  ..:|:|....:|   ..|..:||  ::|..      :..|.||....:.
  Rat  1233 HARGLGFGIRRQNSVNSGILLPVNKDKMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEA 1297

  Fly  1048 ARSQRSYLVKP-PLRKFSLYFKSRQLERDFRS--KAHRFGAENETEGPP 1093
            .:.:..|...| .|.....:...|.||.:.:.  |.|:   |:..|..|
  Rat  1298 PKRKTGYFAAPTQLEPEDQFVVPRDLEDEVKEQMKQHQ---ESRPEPEP 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485
		Guanylate_cyc	361..535	CDD:278633
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761
		PH_PHLPP-like	185..279	CDD:270131
		PLN00113	284..>762	CDD:215061
		leucine-rich repeat	289..309	CDD:275380
		leucine-rich repeat	310..336	CDD:275380
		leucine-rich repeat	337..359	CDD:275380
		leucine-rich repeat	360..382	CDD:275380
		leucine-rich repeat	383..405	CDD:275380
		leucine-rich repeat	406..428	CDD:275380
		leucine-rich repeat	429..452	CDD:275380
		leucine-rich repeat	453..476	CDD:275380
		leucine-rich repeat	477..497	CDD:275380
		leucine-rich repeat	498..517	CDD:275380
		leucine-rich repeat	518..539	CDD:275380
		leucine-rich repeat	540..562	CDD:275380
		leucine-rich repeat	563..584	CDD:275380
		leucine-rich repeat	586..607	CDD:275380
		leucine-rich repeat	608..631	CDD:275380
		leucine-rich repeat	632..681	CDD:275380
		leucine-rich repeat	682..705	CDD:275380
		leucine-rich repeat	706..728	CDD:275380
		leucine-rich repeat	751..772	CDD:275380
		PP2Cc	820..1069	CDD:238083	38/181 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900