Protein Alignment Ac13E and Ac3

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_061511365.1
• Gene: Ac3 / 4578014
• VectorBaseID: AGAMI1_012876
• Length: 1207
• Species: Anopheles gambiae
• Alignment Length: 1727
• Identity: 366/1727 - (21%)
• Similarity: 601/1727 - (34%)
• Gaps: 656/1727 - (37%)

  Fly    43 LSQTGRRHSCCSVMLPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSL 107
            ::|:|..    .|:||.|                 ||::.||:......|:.:    :..|:.|:
Mosquito    11 INQSGTG----GVLLPDA-----------------VLDKLYQSYALKQKRVAF----ACYLIASI 50

  Fly   108 MWCLYFV-VDGGSEDFWRPISSSFSMLSLVTIMALCF--------THWDLYREHRTVTSAVTALL 163
            ::.::.: |..|.......::|.|..:::|..:.|.|        ..|:: ..|.....|:..|.
Mosquito    51 LFDVWAIAVPQGQSVESIVVTSVFLTINIVLAIVLRFCGRGRFRGVIWEI-APHLAWLLAIKQLF 114

  Fly   164 LCGASLAFLTYTGRAFSPLGHFAICLEIVLLIYTALPMPL-----WLGASTAISYSIAFEMVSHM 223
            |    ..||..:......|| :|:.|.  .|:|..||:.|     .||..:..:|..|
Mosquito   115 L----QLFLKGSVTPRDSLG-WAVLLN--FLVYVTLPVLLKYTGILLGLGSFATYVNA------- 165

  Fly   224 VIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRI---LILRIMAHLSVHLVGVHVLIMNLVRMRG 285
            :||.:                       ...|..   .:..|:..::..|:|:....:...:.|.
Mosquito   166 IIGLA-----------------------KKENYFWEQQVANILLLIAATLIGLLCYFLAEAKQRR 207

  Fly   286 TFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASN 350
            .|::..|.|.|:..:|.:...:|:::.||:|..||..:..:.|.:..:.
Mosquito   208 AFLEAKQGLEVKMLIEEQSAEQERLLLSVLPEHVAVKMRQDLGSTNSEQ---------------- 256

  Fly   351 DVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTL 415
                 |:..:|...||||||:|||||||.:|||.:|:.||:|||:||.|||.|.......:|..|
Mosquito   257 -----FKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKILNELFARFDRLAEKYQQLRIKIL 316

  Fly   416 GDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVK 480
            ||||||:||.|..|.|||:.||.|||.|:.|::....:.:..|.||||:|||.||.||:|.|:.:
Mosquito   317 GDCYYCISGAPVERPDHAVLCVHMGLSMVKAIKYVQQKTNSPVDMRVGIHTGAVLAGILGQRQWQ 381

  Fly   481 FDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYL--------EEGEEVFGHRTYFVVGRR 537
            |||:|.||.||||||||||..:||:|::|..||...:.:        ||...:.|.:|||:
Mosquito   382 FDVYSKDVELANKMESSGKAGRVHLSEKTLGFLNGEFEVEPAFGEKREEALRIAGLKTYFI---- 442

  Fly   538 RDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVL 602
                 |..|.|..|:.....|                           |.|...:.....||.:|
Mosquito   443 -----TKVLKPFCPSEHKNGS---------------------------ADPKDVVIEPDGPSEIL 475

  Fly   603 SMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQP 667
                               |:.|.:....:.|.||..|               |.||:.|..:
Mosquito   476 -------------------REDDDDTKPANGANAGDEP---------------STPGTDDKTD-- 504

  Fly   668 PVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEK 732
                   |..:...|....|::|:           ::|.:|..
Mosquito   505 -------PLEDDTQASEDYKMRLR-----------KELVSRDG---------------------- 529

  Fly   733 EELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALA 797
                 |::::.:.|:....|                 :..|.|                     |
Mosquito   530 -----HSEISKDTTIFLTFN-----------------DKTHET---------------------A 551

  Fly   798 SSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVN 862
            .:..|.|.:.|
Mosquito   552 YNEYREPHSAV------------------------------------------------------ 562

  Fly   863 GAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVG 927
                                     ||
Mosquito   563 -------------------------PL-------------------------------------- 564

  Fly   928 GGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSIS 992
                                            .:::..|..|:....:...|.:.:|
Mosquito   565 --------------------------------LAALLVQFVAILYALLVLPRTAVHF-------- 589

  Fly   993 NLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVK 1057
               |:        |.||..::.......:|:.|...|.                      :::
Mosquito   590 ---EI--------VIPPLVIIFVMVFISVAESLTGILP----------------------AFI-- 619

  Fly  1058 PPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYN--TYIDIFVGIAVYLCISVSL 1120
                                                ||.:.|||  |.:.....|.:.|.:.||
Mosquito   620 ------------------------------------TLNSKRYNDSTSLRKSTAIIIVLLLGVS- 647

  Fly  1121 FLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDER 1185
              ...:.::.|.|..::|                          |::|    .|..|.::|
Mosquito   648 --NVSDMLAASHRTPLSL--------------------------NITN----VSFASTEME---- 676

  Fly  1186 GAAPGGRPHFESCADRIFEAISSWYPWHICL--AVLMAMPVLLIIANFLLLDLEQLEAFEYHYGF 1248
                                     |..:||  :......||::||..::..|.       |...
Mosquito   677 -------------------------PASVCLFPSYFSNYTVLILIATSIITQLS-------HLSK 709

  Fly  1249 LIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKWF 1313
            ::.:.|:     |.::|:|.                    ::..:.:.:.:|....|.
Mosquito   710 ILLMIII-----TAIHCYVN--------------------IFHLDEAFRNEDFGIMNV------- 742

  Fly  1314 QDYHVEIYLDLLLILVLV--WFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPK 1376
              :.:...|..||:.|.:  .||.|..:...|:.|.........|.:..:|:.:.:.|::|::|.
Mosquito   743 --FPLRYTLSALLVAVTIALSFLARHIDKVDRVIFMWKTEVIDQKEKASDMRRRNEALVYNVLPM 805

  Fly  1377 HVAEHLKNTAK------YSENHHNIAIIFASIVNFNEMYDESYLG--GKEFLRVLNELIGDFDEL 1433
            |||||.....|      ||:::..:.::|||:.||::.|.|..:.  |.|.||.|||:|.|||.|
Mosquito   806 HVAEHFMGNRKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDAL 870

  Fly  1434 LSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGDE-------HIHTLMEFSIAMQEVVDAFNKDL 1491
            |..|:|:.:.||||||||:||||||:||.....|:       |:..|:||::.:::.:...|:.
Mosquito   871 LELPQFQDIIKIKTIGSTYMAASGLNPSRIVKPDDPVSVRWAHLALLVEFALELKKALQGINEQ- 934

  Fly  1492 LEFN-LILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKD-CLPFLTNR 1554
             .|| .:|::|:|.|.:||||||..|.:|||||:.|||||||:|||....|||.:: |....|..
Mosquito   935 -SFNHFVLKMGVNHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCQILQTFG 998

  Fly  1555 YEFEPRGSVYVKGKDHMEVFLYTTRRDNPLDDDEADKVEQLGTKKMEHEGRDEDVVQGEQQAEDK 1619
            |.||.||.|.||||..:..:....:...|.....:                  .::|.....|..
Mosquito   999 YTFEQRGLVAVKGKGQLMTYYLQGKVPRPTGPTAS------------------PILQNLTAMETV 1045

  Fly  1620 DEEEEEEEEDDDLHSSETTTLFKSQESLQANGGSHLAPNAAATSHTHTITLTNNNN-----HNSS 1679
            .|.:|.:|....|..........:.:....:..|..:||:...:..:.....:|.:     .:||
Mosquito  1046 QEVDESKESPPALAPPPGDGASPAHQLHSVSSPSTASPNSVRLNQEYVEMKASNASTAMLQESSS 1110

  Fly  1680 NINNNIATSNTT-------------TTANNNSMPVET 1703
            :|:||..|:.:|             :|::.:|..|||
Mosquito  1111 SISNNTTTTTSTKLTVVSEKTTTISSTSSTSSTTVET 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	95/215 (44%)
		PHA03307	836..>1015	CDD:223039	10/178 (6%)
		Guanylate_cyc	1388..1575	CDD:425528	89/197 (45%)
Ac3	XP_061511365.1	None