DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and Gycalpha99B

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster

Alignment Length:	428	Identity:	112/428 - (26%)
Similarity:	174/428 - (40%)	Gaps:	99/428 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 LTYTGRAFS----------------------PLGHFAICLEIVLLIYTALPMPLWLGAST---AI 211
            |...||.||                      |.|......:||...||    |..:|.:.   |:
  Fly   282 LVQLGRGFSKLYKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYT----PFLIGLNNPPGAV 342

  Fly   212 SY-SIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAH---LSVHLVG 272
            .: :|..|:...|| .|...:.....|.....|..|:..||     :.|..|..|   ..|.|||
  Fly   343 DFPAIGLEIKGQMV-HCPESNSLLFIGSPFLDGLDGLTCNG-----LFISDIPLHDATREVILVG 401

  Fly   273 VHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKE--KMIHSVMPPKVADML-LNEGGPSGLDA 334
            ......:.:|.|   |...:|.:......:.|:.|:  .::|.:.|.::|:.| |.    |.:||
  Fly   402 EQARAQDGLRRR---MDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLG----SSIDA 459

  Fly   335 GGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFER 399
            ...|                           :|:|||:||||||.:.|..|...::.:|..|::.
  Fly   460 KTYP---------------------------DVTILFSDIVGFTSICSRATPFMVISMLEGLYKD 497

  Fly   400 FDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEG--VKMRV 462
            ||:.|......|:.|:||.|...||........|.....|.|.||||  |.....|:|  :|||:
  Fly   498 FDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMIDA--CSKHITHDGEQIKMRI 560

  Fly   463 GVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFL----GDAYYLEEGE 523
            |:||||||.|:||.:..::.::.:.|::|||.||..:..::::|..|..:|    |..:.|:..:
  Fly   561 GLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEFELQPRD 625

  Fly   524 EVF---------GHRT-YFVVGRRRDFTRTNSLSPSMP 551
            ..|         |..| ||:     :..|..:|...:|
  Fly   626 PSFLPKEFPNPGGTETCYFL-----ESFRNPALDSELP 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	68/224 (30%)
		Guanylate_cyc	361..535	CDD:278633	63/189 (33%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	40/181 (22%)
		CYCc	430..619	CDD:214485	68/221 (31%)
		Guanylate_cyc	457..647	CDD:278633	66/223 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454021
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740