DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and Adcy1

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_033752.1	Gene:	Adcy1 / 432530	MGIID:	99677	Length:	1118	Species:	Mus musculus

Alignment Length:	1541	Identity:	341/1541 - (22%)
Similarity:	522/1541 - (33%)	Gaps:	585/1541 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 GGSEDFWRPISSSFSMLSLVTIMALCFTHWDLYREHRTVTSAVTALLLCGASLAFLTYTGRAFSP 181
            ||...| |.....|:...|..:    |..:.|..|......|:..|.|...:||.....|.....
Mouse    27 GGRRGF-RACGEEFACPELEAL----FRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPA 86

  Fly   182 LG-----HFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGA 241
            .|     |...|:..:.|........|.:.....:.....|..::..::.|....|||.....|.
Mouse    87 PGLAKGSHPVHCILFLALFVVTNVRSLQVSQLQQVGQLALFFSLTFALLCCPFALGGPARSSAGG 151

  Fly   242 AGGSGMEANG----------------------------------------DPSNRILILRIMA-- 264
            |.||.:...|                                        .|:.|..:.|.:.
Mouse   152 AMGSTVAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRLWRTLGAN 216

  Fly   265 ---HLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVA-----D 321
               ...|::.||.|.|:.....|..|::....:..|.:||.|.:.:|:::.|::|..||     |
Mouse   217 ALLFFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKED 281

  Fly   322 MLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTA 386
            .|             .|||             .:|...::...:|||||||||||||.::|..||
Mouse   282 FL-------------KPPE-------------RIFHKIYIQRHDNVSILFADIVGFTGLASQCTA 320

  Fly   387 EQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFD 451
            ::||::||:||.:||:|.:.:.|.:|..||||||||||..:|:.|||.|||||||.|||.:....
Mouse   321 QELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVA 385

  Fly   452 AQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDA 516
            ......:.||||:|||.||||::|.|:.::|||||||:|||.||::|.|.:|||::.|.:.|...
Mouse   386 EATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGD 450

  Fly   517 YYLEEGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQP 581
            |.:|.|.   ||       .|..|.||:::....
Mouse   451 YEVEPGH---GH-------ERNTFLRTHNIETFF------------------------------- 474

  Fly   582 NVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRE 646
                                                                        ||...
Mouse   475 ------------------------------------------------------------IVPSH 479

  Fly   647 RPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSC 711
            |.||      .||.:.||         :.||.....:|...:.:::....:..|.....:|..:|
Mouse   480 RRKI------FPGLILSD---------IKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTC 529

  Fly   712 GGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQ 776
            .        |.::.|......|:|...:        :|..|.:..
Mouse   530 E--------DDDKRRALRTASEKLRNRS--------SFSTNVVYT-------------------- 558

  Fly   777 TLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDIS 841
                                                   :||        ..|..|||:.
Mouse   559 ---------------------------------------TPG--------TRVNRYISRL----- 571

  Fly   842 PFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNS 906
                                         .|.|    ||  .:|.:.|
Mouse   572 -----------------------------LEAR----QT--ELEMADL----------------- 584

  Fly   907 LEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALN 971
                                                  :..:.|...::...:...:|.:
Mouse   585 --------------------------------------NFFTLKYKHVEREQKYHQLQDE----- 606

  Fly   972 QTAISQHRVSGYFTSSTSSISNLGEVQG----LGLPLAVQPPPPLLMPACSSQMADPLAACLQQL 1032
                       ||||:......|..:.|    |.:|.:|.....|:...|.      |.||...|
Mouse   607 -----------YFTSAVVLALILAALFGLIYLLVIPQSVAVLLLLVFSICF------LVACTLYL 654

  Fly  1033 RKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLAT 1097
            .    :..::|.                                                |...|
Mouse   655 H----ITRVQCF------------------------------------------------PGCLT 667

  Fly  1098 PRYNTYIDIFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQS 1162
            .:..|.:.:|:.:.:|   ||:.                   .|..|...:|
Mouse   668 IQIRTALCVFIVVLIY---SVAQ-------------------GCVVGCLPWA------------- 697

  Fly  1163 GSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLM-AMPVLL 1226
                   :.|:|.:|..:      .|.|||       ..:..|:......|..|..|: .:|:.:
Mouse   698 -------WSSQSNSSLVV------LAAGGR-------RTVLPALPCESAHHALLCCLVGTLPLAI 742

  Fly  1227 IIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYS 1291
            .:....|..:..|......|     :.::....:|::.                |.|:|
Mouse   743 FLRVSSLPKMILLSGLTTSY-----ILVLELSGYTKVG----------------GGALS------ 780

  Fly  1292 HNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDK 1356
             .||                      .|..:.:||....:....|:.::..||.:...|.|.:::
Mouse   781 -GRS----------------------YEPIMAILLFSCTLALHARQVDVRLRLDYLWAAQAEEER 822

  Fly  1357 VRVQNMKNQADMLLHNIIPKHVAEHL-----KNTAKYSENHHNIAIIFASIVNFNEMYDESYLGG 1416
            ..::.:|.....:|.|::|.|||:|.     :|...|.:::..:.::||||.|||:.|.|  |.|
Mouse   823 DDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIE--LDG 885

  Fly  1417 K----EFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTG-----DEHIHT 1472
            .    |.||:|||:|.|||||:.:..::.:|||||||||:|||.||.|: .||.     ..|:.|
Mouse   886 NNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPT-AGTRAKKSISSHLCT 949

  Fly  1473 LMEFSIAMQEVVDAFNKDLLEFN-LILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTG 1536
            |.:|:|.|.:|:|..|..  .:| .:||:|:|:|.|.|||||..:..|||||:.|||||||||||
Mouse   950 LADFAIDMFDVLDEINYQ--SYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTG 1012

  Fly  1537 LPNRIQVGKDCLPFLTN-RYEFEPRGSVYVKGKDHMEVFLYTTRRD 1581
            :..||||.::....|.. .|:|..||.|.||||..|..:....|.|
Mouse  1013 VQGRIQVTEEVHRLLKRCSYQFVCRGKVSVKGKGEMLTYFLEGRTD 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	95/220 (43%)
		Guanylate_cyc	361..535	CDD:278633	88/173 (51%)
		CYCc	1362..1556	CDD:214485	92/209 (44%)
		Guanylate_cyc	1388..1575	CDD:278633	93/197 (47%)
Adcy1	NP_033752.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		341/1541 (22%)
		AC_N	<158..291	CDD:292831	25/158 (16%)
		CYCc	257..452	CDD:214485	95/220 (43%)
		Guanylate_cyc	293..475	CDD:278633	92/282 (33%)
		Interaction with calmodulin. /evidence=ECO:0000250	492..519		3/26 (12%)
		CYCc	825..1036	CDD:214485	94/215 (44%)
		Guanylate_cyc	858..1055	CDD:278633	93/201 (46%)
		Interaction with calmodulin. /evidence=ECO:0000250	1023..1046		9/22 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1079..1118
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810