Protein Alignment Ac13E and Adcy1

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_033752.1
• Gene: Adcy1 / 432530
• MGIID: 99677
• Length: 1118
• Species: Mus musculus
• Alignment Length: 1541
• Identity: 341/1541 - (22%)
• Similarity: 522/1541 - (33%)
• Gaps: 585/1541 - (37%)

  Fly   117 GGSEDFWRPISSSFSMLSLVTIMALCFTHWDLYREHRTVTSAVTALLLCGASLAFLTYTGRAFSP 181
            ||...| |.....|:...|..:    |..:.|..|......|:..|.|...:||.....|.....
Mouse    27 GGRRGF-RACGEEFACPELEAL----FRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPA 86

  Fly   182 LG-----HFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGA 241
            .|     |...|:..:.|........|.:.....:.....|..::..::.|....|||.....|.
Mouse    87 PGLAKGSHPVHCILFLALFVVTNVRSLQVSQLQQVGQLALFFSLTFALLCCPFALGGPARSSAGG 151

  Fly   242 AGGSGMEANG----------------------------------------DPSNRILILRIMA-- 264
            |.||.:...|                                        .|:.|..:.|.:.
Mouse   152 AMGSTVAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRLWRTLGAN 216

  Fly   265 ---HLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVA-----D 321
               ...|::.||.|.|:.....|..|::....:..|.:||.|.:.:|:::.|::|..||     |
Mouse   217 ALLFFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKED 281

  Fly   322 MLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTA 386
            .|             .|||             .:|...::...:|||||||||||||.::|..||
Mouse   282 FL-------------KPPE-------------RIFHKIYIQRHDNVSILFADIVGFTGLASQCTA 320

  Fly   387 EQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFD 451
            ::||::||:||.:||:|.:.:.|.:|..||||||||||..:|:.|||.|||||||.|||.:....
Mouse   321 QELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVA 385

  Fly   452 AQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDA 516
            ......:.||||:|||.||||::|.|:.::|||||||:|||.||::|.|.:|||::.|.:.|...
Mouse   386 EATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGD 450

  Fly   517 YYLEEGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQP 581
            |.:|.|.   ||       .|..|.||:::....
Mouse   451 YEVEPGH---GH-------ERNTFLRTHNIETFF------------------------------- 474

  Fly   582 NVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRE 646
                                                                        ||...
Mouse   475 ------------------------------------------------------------IVPSH 479

  Fly   647 RPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSC 711
            |.||      .||.:.||         :.||.....:|...:.:::....:..|.....:|..:|
Mouse   480 RRKI------FPGLILSD---------IKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTC 529

  Fly   712 GGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQ 776
            .        |.::.|......|:|...:        :|..|.:..
Mouse   530 E--------DDDKRRALRTASEKLRNRS--------SFSTNVVYT-------------------- 558

  Fly   777 TLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDIS 841
                                                   :||        ..|..|||:.
Mouse   559 ---------------------------------------TPG--------TRVNRYISRL----- 571

  Fly   842 PFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNS 906
                                         .|.|    ||  .:|.:.|
Mouse   572 -----------------------------LEAR----QT--ELEMADL----------------- 584

  Fly   907 LEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALN 971
                                                  :..:.|...::...:...:|.:
Mouse   585 --------------------------------------NFFTLKYKHVEREQKYHQLQDE----- 606

  Fly   972 QTAISQHRVSGYFTSSTSSISNLGEVQG----LGLPLAVQPPPPLLMPACSSQMADPLAACLQQL 1032
                       ||||:......|..:.|    |.:|.:|.....|:...|.      |.||...|
Mouse   607 -----------YFTSAVVLALILAALFGLIYLLVIPQSVAVLLLLVFSICF------LVACTLYL 654

  Fly  1033 RKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLAT 1097
            .    :..::|.                                                |...|
Mouse   655 H----ITRVQCF------------------------------------------------PGCLT 667

  Fly  1098 PRYNTYIDIFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQS 1162
            .:..|.:.:|:.:.:|   ||:.                   .|..|...:|
Mouse   668 IQIRTALCVFIVVLIY---SVAQ-------------------GCVVGCLPWA------------- 697

  Fly  1163 GSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLM-AMPVLL 1226
                   :.|:|.:|..:      .|.|||       ..:..|:......|..|..|: .:|:.:
Mouse   698 -------WSSQSNSSLVV------LAAGGR-------RTVLPALPCESAHHALLCCLVGTLPLAI 742

  Fly  1227 IIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYS 1291
            .:....|..:..|......|     :.::....:|::.                |.|:|
Mouse   743 FLRVSSLPKMILLSGLTTSY-----ILVLELSGYTKVG----------------GGALS------ 780

  Fly  1292 HNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDK 1356
             .||                      .|..:.:||....:....|:.::..||.:...|.|.:::
Mouse   781 -GRS----------------------YEPIMAILLFSCTLALHARQVDVRLRLDYLWAAQAEEER 822

  Fly  1357 VRVQNMKNQADMLLHNIIPKHVAEHL-----KNTAKYSENHHNIAIIFASIVNFNEMYDESYLGG 1416
            ..::.:|.....:|.|::|.|||:|.     :|...|.:::..:.::||||.|||:.|.|  |.|
Mouse   823 DDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIE--LDG 885

  Fly  1417 K----EFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTG-----DEHIHT 1472
            .    |.||:|||:|.|||||:.:..::.:|||||||||:|||.||.|: .||.     ..|:.|
Mouse   886 NNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPT-AGTRAKKSISSHLCT 949

  Fly  1473 LMEFSIAMQEVVDAFNKDLLEFN-LILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTG 1536
            |.:|:|.|.:|:|..|..  .:| .:||:|:|:|.|.|||||..:..|||||:.|||||||||||
Mouse   950 LADFAIDMFDVLDEINYQ--SYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTG 1012

  Fly  1537 LPNRIQVGKDCLPFLTN-RYEFEPRGSVYVKGKDHMEVFLYTTRRD 1581
            :..||||.::....|.. .|:|..||.|.||||..|..:....|.|
Mouse  1013 VQGRIQVTEEVHRLLKRCSYQFVCRGKVSVKGKGEMLTYFLEGRTD 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	95/220 (43%)
		PHA03307	836..>1015	CDD:223039	18/182 (10%)
		Guanylate_cyc	1388..1575	CDD:425528	93/197 (47%)
Adcy1	NP_033752.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		341/1541 (22%)
		AcyC	99..455	CDD:441717	121/381 (32%)
		Guanylate_cyc	293..475	CDD:425528	92/282 (33%)
		Interaction with calmodulin. /evidence=ECO:0000250	492..519		3/26 (12%)
		Guanylate_cyc	858..1055	CDD:425528	93/201 (46%)
		Interaction with calmodulin. /evidence=ECO:0000250	1023..1046		9/22 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1079..1118