DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and CG31183

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster

Alignment Length:	711	Identity:	164/711 - (23%)
Similarity:	260/711 - (36%)	Gaps:	207/711 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 MEANGDPSNRI--LILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVG---QNLLVRRQL------ 300
            :|.|||....|  :|.|..|.........:.| .:::|......:.|   .|||.|.:|
  Fly   842 LEPNGDTKADINGIIRRCWAEDPAERPDFNTL-KSMIRRFNKDNETGNIVDNLLKRMELYANNLE 905

  Fly   301 ----------EMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSL 355
                      ..||:..||:::.::|..||..|:     ||
  Fly   906 ELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLI-----SG------------------------ 941

  Fly   356 FRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYY 420
             :|....:.:.|:|.|:||||||.:|:..|..|:|:.||||:..||.:.......|:.|:||.|.
  Fly   942 -QPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYM 1005

  Fly   421 CVSGCPEPRAD-HAICCVEMGLGMIDAMRCFDAQR--HEGVKMRVGVHTGTVLCGIVGTRRVKFD 482
            .|||.|....: ||.....:.|.:::|:..|....  .:.:|:|:|:|||..:.|:||.:..::.
  Fly  1006 VVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYC 1070

  Fly   483 VWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHR------------TYFVVG 535
            ::.:.|:.|::|||:|:..::|||:.|...|.     |.|..|...|            ||::.|
  Fly  1071 LFGDTVNTASRMESNGEALKIHISETTKEALD-----EFGTFVTTRRGFVPMKGKGEMLTYWLEG 1130

  Fly   536 RRRDFTRTNSL-SPSMPANATGSSLLLP---GAHGASLSQSATNVSAVQPNVPPASPVGQLSSSL 596
               :..|.||| |||.......|||..|   .:|......|...|::..|.:||  |...|....
  Fly  1131 ---EVPRPNSLISPSKLMLTRRSSLKQPQRSQSHNLHKQYSELVVASPPPQLPP--PAIALPPPP 1190

  Fly   597 NP---SPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLP 658
            :|   ||.|.::.:::|.|.|:........: .|...:..|||.        :|...|.:::||.
  Fly  1191 SPSKDSPNLRVKRKISSSSPKLNGGGFDYHK-TENHYLDTAAAA--------QRNCDIYSSRSLR 1246

  Fly   659 GSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRF-------LKRFEDLTNRS-----SC 711
            ...::.:.                          |::..|       ||....|.|.|     |.
  Fly  1247 DMEETSDS--------------------------WELAHFRLPLSGALKSHHHLNNNSHGYVHSN 1285

  Fly   712 GGSSSAGHLDKEREREREKEKEELH-QHNQLNPEETLA-FMDNQMQNGN--------GCGYQQLP 766
            ..|:.:|.|          :...|. |..:|.|..|:: .:.:.....|        ..|..||.
  Fly  1286 SSSNLSGIL----------QPPPLGVQRTRLKPSPTISTLLTSARSEANASPGPETGSMGSGQLR 1340

  Fly   767 VLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRS 831
            :.......|..|..|   |.|   |....:...|..||:   ..|.|...|...|.|..::.
  Fly  1341 IKFAEGDETPLLPTP---PPL---AAPPPIPQMVAASPQ---RSGSGQNIPADSSHYGFLVK--- 1393

  Fly   832 YISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRP 892
                            ||:.||                            |||..|.:.:|
  Fly  1394 ----------------SYKQQC----------------------------PPVAGSAVTQP 1410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	64/218 (29%)
		Guanylate_cyc	361..535	CDD:278633	59/188 (31%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	10/41 (24%)
		Pkinase_Tyr	613..877	CDD:285015	9/35 (26%)
		HNOBA	<893..938	CDD:285003	11/44 (25%)
		CYCc	917..1108	CDD:214485	66/225 (29%)
		Guanylate_cyc	944..1130	CDD:278633	59/190 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830