Protein Alignment Ac13E and Ac78C

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Alignment Length: 1810
• Identity: 414/1810 - (22%)
• Similarity: 662/1810 - (36%)
• Gaps: 593/1810 - (32%)

  Fly    70 LDPKFDSPVLEEQYQASVFPHVRMRYR---------FTLSYILLCSLMWCLYFVVDGGSEDFWRP 125
            |...|....||..|  ..:.| |.|.:         |.|..:|  :.:|.:.....|       |
  Fly   303 LTNSFKQSSLERSY--LTYTH-RQRQKSLIIVNVVDFVLKIVL--AFVWIMRRSELG-------P 355

  Fly   126 ISS--SFSMLSLVT--------IMALCFT-HWDLYREHRTVTSAVTALLLCGASLAFLTYTGRAF 179
            |.|  ..||.:.:|        .||:||. :|..:..:....:||...:|  .::......|..|
  Fly   356 IESDDGTSMATAITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVL--FNIQGFVGQGVGF 418

  Fly   180 SPLGHFA-ICLEIVLLIYTALPMPL-WLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAA 242
            :...:.. ..|.::.:.|..||:|| |......|:.|....:::.:.:         .||
  Fly   419 ADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKL---------QHG----- 469

  Fly   243 GGSGMEANGDPSNRILILRIMA----HLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEME 303
                 ||..:|  ..::.:|.|    :.::::.|::...:.....|..|::..:.:..:::.|.|
  Fly   470 -----EATINP--ECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKE 527

  Fly   304 KQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVS 368
            .|..:|::.|::|..|.:.:.:|                 |.......|::.|...:::.|:|||
  Fly   528 LQRTQKLLDSILPNIVNNQIRSE-----------------MYKGTDPTVETQFNKLYVYPMDNVS 575

  Fly   369 ILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCP----EPR 429
            ||||||.|||.::|..:|:|||:||||||.|||.:...:.|.::..|||||||||...    :.|
  Fly   576 ILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTR 640

  Fly   430 ADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKM 494
            .|||:|.||.||.||.|::......|..:.||:|:|:|:|:||::|.::..||||||||.:||.|
  Fly   641 PDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHM 705

  Fly   495 ESSGKPEQVHISQETSSFLGDAYYLEEGE--------EVFGHRTYFVV------GRRRDFTRTN- 544
            ||.|.|.:||||:.|...|.|||.:|.|.        ::...:||.:.      .:||..||::
  Fly   706 ESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSA 770

  Fly   545 ----SLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMR 605
                |::.:.|..||.::  ||.:..||.|.|...|:|          .|...:|::
  Fly   771 HLAGSVATAAPPCATPTA--LPKSISASGSGSIGGVTA----------TGNDGASID-------- 815

  Fly   606 PRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIP---PVIVVRERPKIIITTKSLPGSLDSDEQP 667
                                 .|.:.:.|...:|   |..:::::.|..|:..|||..::...
  Fly   816 ---------------------GRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVA-- 857

  Fly   668 PVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEK 732
                                                                :|..|.|
  Fly   858 ----------------------------------------------------MDSRRIR------ 864

  Fly   733 EELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALA 797
                                     |||
  Fly   865 -------------------------NGC------------------------------------- 867

  Fly   798 SSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVN 862
                     ||.||.|                                           .||| .
  Fly   868 ---------GVMGGAG-------------------------------------------GTGG-G 879

  Fly   863 GAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVG 927
            |.||.|:.... :.|:..:.|:|....||..|                      |.:.....::.
  Fly   880 GTGPCGMSTVS-SPTAMMSAPLEVQLRPRNGA----------------------CSIQNLAEAID 921

  Fly   928 GGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSIS 992
            |.|:.....|....|........:|.....:|..||      |..|. ..||||
  Fly   922 GKGLIIEDESTTDWIPEIPFKNLNSPEDGLNRADSI------LVDTK-EDHRVS----------- 968

  Fly   993 NLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVK 1057
                       :||              :.:.:...::|     ::|    :..|...:|.|
  Fly   969 -----------VAV--------------LDEEIDEFIEQ-----NIQ----INSNKEIRREY--- 996

  Fly  1058 PPLRKFSLYFKSRQLERDF---RSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAVY------ 1113
              |..::|.||.:..|:.|   |....|                  :..:.:|| |.::
  Fly   997 --LNPWTLKFKDKSQEQKFCQLREDMFR------------------SNMLCVFV-IWIFMVLCQV 1040

  Fly  1114 ----------LCISVSLFLMT-----------------QNTVSPSF---RLWVTLFSCFTGIQVF 1148
                      :|:||...::|                 ..|.|...   |...|||.|  |:.|.
  Fly  1041 IIIPRCTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFIC--GVIVS 1103

  Fly  1149 ALFL----------------------FTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAP-G 1190
            ...|                      |.|.:....:.|.....|:.....|..:..:...:.| .
  Fly  1104 MCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPAS 1168

  Fly  1191 GRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLI--------------------IANFLLLD 1235
            |.|      ..:.:..||........:.|.|:.:.|.                    ::|....|
  Fly  1169 GGP------TPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSD 1227

  Fly  1236 LEQLEAFE------YHYGFLIF---VCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYS 1291
            ...:::..      .|..:|:|   :|:|......:|...|:.::| ||.:.|    .:.|::..
  Fly  1228 ASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMA-LAMVAF----YTTLIMMK 1287

  Fly  1292 HNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDK 1356
            ....|.....|.|.....:      .|::.:.|:..||:|.:..|..|:..||.|.....|.::
  Fly  1288 FGSGDSFSLVELSRLGMPL------GVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERE- 1345

  Fly  1357 VRVQNMK-NQA--DMLLHNIIPKHVA------EHLKNTAKYSENHHNIAIIFASIVNFNEMYDES 1412
              :.||| |:|  |.|:.||:|.|||      ||....  ||:.|:...::||||.||.:.|.|.
  Fly  1346 --LTNMKSNRALNDTLIKNILPDHVATYYLSDEHTDEL--YSKMHNLCGVMFASIPNFQDFYSED 1406

  Fly  1413 YLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSH---RG-TGDEHIHTL 1473
            ...||..:|:|||:|.||||||..|.|.:||||||:|:|:|||:||:..|   || |.::.:..|
  Fly  1407 IDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDL 1471

  Fly  1474 MEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLP 1538
            :||:.||::.::..|.|... |..||:|:..|.:.:||||..|..|||||:.|||||||||||..
  Fly  1472 VEFAFAMKQKLEEINGDAFN-NFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGEN 1535

  Fly  1539 NRIQVGKDCLPFLTNR-YEFEPRGSVYVKGKDHMEVFLYTTRRDNPLDDDEADKVEQLG------ 1596
            .|:||.::....|.:| |....||.:.||||..|..|..     :|....|:..:..:.
  Fly  1536 WRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYV-----HPKGISESQLISPVRMPAGIP 1595

  Fly  1597 -------TKKMEHEGRDEDVVQGEQQAEDKDEEEEEEEEDDDLHSSETTTLFKSQESLQANGGSH 1654
                   .::..|.|....||.|..||..:...           .:.|.|...|.:..:.:.||.
  Fly  1596 LAQTPNLQRQTSHHGSFSAVVFGMLQASKRSTA-----------IAGTPTGTPSPQIRRGHRGST 1649

  Fly  1655 LAPNAAATSHTHTITLTNNN---------NHNSSNINNNIATSNTTTTANNNSMP 1700
            .: :...:..:.|:.....|         ....|:.||:|.|.     |:::.||
  Fly  1650 FS-SVRLSQKSTTVNPVRRNTTRVRGRSYRQKKSSSNNSIVTQ-----ASSSYMP 1698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	92/219 (42%)
		Guanylate_cyc	361..535	CDD:278633	87/191 (46%)
		CYCc	1362..1556	CDD:214485	95/207 (46%)
		Guanylate_cyc	1388..1575	CDD:278633	89/191 (47%)
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	56/299 (19%)
		CYCc	526..729	CDD:214485	92/219 (42%)
		Guanylate_cyc	566..753	CDD:278633	87/186 (47%)
		DUF1053	929..1020	CDD:283888	26/147 (18%)
		CYCc	1353..1554	CDD:214485	92/203 (45%)
		Guanylate_cyc	1381..1576	CDD:278633	90/202 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910