Protein Alignment Ac13E and Ac76E

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Alignment Length: 1620
• Identity: 412/1620 - (25%)
• Similarity: 650/1620 - (40%)
• Gaps: 453/1620 - (27%)

  Fly    64 AAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYI-LLCSLMWCLYFVVDGGSEDFWRPIS 127
            :|:.:.|..:.:....|:.:...::...|.|.|.:|... ||.||:.|:..::.|
  Fly    47 SASLADLSEQENGTTAEDIHLNDLYTRYRQRLRKSLFRSGLLTSLLACVVSIIIG---------- 101

  Fly   128 SSFSMLSLVTIMALCFTHWDLYREHRTVTS-AVTALLLCG----------------ASLAF---- 171
                               .:|.:|...|. .|.|.|:.|                |:|||
  Fly   102 -------------------IVYGQHLVQTMLLVLAALISGSILTALQFPAVLSSPAAALAFAIVT 147

  Fly   172 -------LTYTGRAFSPLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVS-HMV--IG 226
                   ...||...:||..:|    :.|.|::.||:      |..:|..:|..|.: |:|  ||
  Fly   148 TFSLGTIAAITGDELAPLPMYA----LFLCIHSMLPI------SWPVSVVLALFMTAIHIVYRIG 202

  Fly   227 CSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVG 291
            .|..:.                    |:..:|...|:...|..:.|::..||:......|.....
  Fly   203 TSPDYA--------------------PNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTR 247

  Fly   292 QNLLVRRQLEMEKQLKEKMIHSVMPP------------KVADMLLNEGGPSGLDAGGLPPESHYM 344
            ..:..|.:||.|::.:|:::.||:|.            |:||.....||.:...|
  Fly   248 TGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSA---------- 302

  Fly   345 RPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGC 409
                     :.|...|:....||:|||||||.||.:||:.||..||:.|||||.|||.:...:.|
  Fly   303 ---------TRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQC 358

  Fly   410 EKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIV 474
            .:|..||||||||||.|..|..||..||.|||.||||:|.........|.||:|:|||.||||::
  Fly   359 LRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVL 423

  Fly   475 GTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRD 539
            |.|:.:|||||:||:|||.|||.|...:|||:::|..||||.:.:|:||.  |:|..::...:.:
  Fly   424 GLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEG--GNRDAYLADHKVE 486

  Fly   540 FTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSM 604
                             |.|::|.....:.|.... |..::.|              :|||.
  Fly   487 -----------------SYLIVPPKPAYTYSVPRV-VECIEQN--------------DPSPT--- 516

  Fly   605 RPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPV 669
                |..:.::::..||.:......::.|.....||.||         ..|..|.|::|.| .|:
  Fly   517 ----TEETKEIKETDQSHEATDVADVLLPVTVAPPPAIV---------DEKMSPTSINSQE-APL 567

  Fly   670 SPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEE 734
            ..||...|:....|               |...||..:.:: ..:....|.|::.:.::|.:
  Fly   568 HAPLASAASMSIKE---------------LSEEEDEADEAT-AVTEPLMHRDQDGKNDKEPK--- 613

  Fly   735 LHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASS 799
                                .||.                             |..:..:|.:.|
  Fly   614 --------------------ANGG-----------------------------HRGSGDSAASES 629

  Fly   800 VLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGA 864
            |.:|....:..             ||::.    :|.|.|.||   .||: ::|....::.....|
  Fly   630 VAKSAALSLPA-------------DDLLS----MSGSESGIS---NSGA-QAQSSNPASVTPTAA 673

  Fly   865 GPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGG 929
            .||| ||...:.|...||...:..|                                   ||.|
  Fly   674 APAG-GAASNSLTVAEAPERSRRKL-----------------------------------SVQG- 701

  Fly   930 GIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQ-QIYALNQTAISQHRVSGYFT------SS 987
                        :...|..|:.||.....|:.||.. :.:..:...::::|.|...|      .:
  Fly   702 ------------LMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGA 754

  Fly   988 TSSISNLGE---VQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNAR 1049
            ....:|:.|   |:.:||.........||.|.                ||        |...|
  Fly   755 DRPFANIAESKLVKNIGLASIAMIESNLLPPE----------------RK--------CFNFN-- 793

  Fly  1050 SQRSYLVKPP--LRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAV 1112
                 ...||  |:.|::::::...|..:|                  |.|..:...|:.....:
  Fly   794 -----FFGPPTELKPFTMWYRNTPREAMYR------------------AQPDTHFRFDLICAFVL 835

  Fly  1113 YLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTS 1177
            :|.::|...::    :..:..|..:|.:.|..:   ||||:.         ||:|......|||
  Fly   836 FLSLAVVQLIV----IELNLALLGSLLASFVSL---ALFLYL---------SNMSVPDVHASTT- 883

  Fly  1178 EDLERDERGAAPGGRPH------------FESCADRIFEAISSWYPWHICLAVLMAMPVLLIIAN 1230
               ||:..|.......:            ..|||  :|..|:...|..:.........:|  .:|
  Fly   884 ---ERNGPGQVVASSRYLRLAMFVVVNILISSCA--VFSVINYTVPDGVSKEPSSNQTIL--ESN 941

  Fly  1231 FLLL----DLEQLEAFEYHYGFLIFVCIVHFC--NFTQLNCWVRN--VLAFLAALCFIGIAVSQL 1287
            |..:    .||.::.:|..|...|....::.|  :...::.::|:  :|..:|.|..:   ::|:
  Fly   942 FSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAMLVAV---IAQV 1003

  Fly  1288 MVYSHNRSDQQQDQEASNFIQ----EIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYG 1348
            .|..:  ||..:....:|...    |||.|        |.||:|::::..|:|:.|...|..|..
  Fly  1004 TVLGY--SDLFEMYNDANITHGLPLEIKGF--------LLLLVIILVLHTLDRQGEYVARTDFLW 1058

  Fly  1349 NAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHL----KNTAKYSENHHNIAIIFASIVNFNEMY 1409
            .|....::..|:.|:....:||.||:|.|||.|.    ::|..|.|::..:|::||||.|:.|.|
  Fly  1059 KAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERSTELYHESYSCVAVMFASIPNYKEFY 1123

  Fly  1410 DESYLG--GKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDP------------ 1460
            ||:.:.  |.|.||:|||:|.|||:||.:|:|..:||||||.||:|.||||.|
  Fly  1124 DETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFA 1188

  Fly  1461 SHRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDA 1525
            ..:.|.:.::..|:||:||:..::|:.|::..: ...||||:|.|.|.|||||..|..||||.:.
  Fly  1189 DEKRTEEHNVVILVEFAIALMSILDSINRESFQ-RFRLRIGLNHGPVIAGVIGAQKPQYDIWSNT 1252

  Fly  1526 VNVASRMDSTGLPNRIQVGKDCLPFL-TNRYEFEPRGSVYVKGKDHMEVFLYTTRRDNPL 1584
            |||||||||.|:..|:|..::....| |..||.|.||..|||||.::..:...|..|..|
  Fly  1253 VNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFVKTPFDGKL 1312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	99/227 (44%)
		Guanylate_cyc	361..535	CDD:278633	91/173 (53%)
		CYCc	1362..1556	CDD:214485	91/212 (43%)
		Guanylate_cyc	1388..1575	CDD:278633	90/201 (45%)
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	56/280 (20%)
		CYCc	259..467	CDD:214485	99/226 (44%)
		Guanylate_cyc	311..469	CDD:278633	86/157 (55%)
		BASP1	510..667	CDD:283191	45/276 (16%)
		CYCc	1079..1283	CDD:214485	90/204 (44%)
		Guanylate_cyc	1101..1305	CDD:278633	90/204 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454028
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840