DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and CG42637

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	759	Identity:	181/759 - (23%)
Similarity:	270/759 - (35%)	Gaps:	242/759 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 VLIMNLVRMRG------------TFMKVGQNL----LVRRQLEMEKQLK-EKMIHSVMPPKVADM 322
            |:...|.:|||            ...|...||    ..|.:|..|:::| |.::|.::|..||:.
  Fly   816 VIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEK 880

  Fly   323 LLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAE 387
            |..        ..|:.|.|:                      :.|:|.|:||||||.||:..|..
  Fly   881 LTM--------GQGVEPVSY----------------------DLVTIYFSDIVGFTAMSAESTPL 915

  Fly   388 QLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRAD-HAICCVEMGLGMIDAMRCFD 451
            |:|..||||:..||.:.......|:.|:||.|..|||.|....| ||.....|.|.::.|::...
  Fly   916 QVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHR 980

  Fly   452 -AQR-HEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETS---S 511
             |.| :|.:|:|:|:|||.|:.|:||....::.::.:.|:.|::|||:|:..::|||.:..   .
  Fly   981 IAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALD 1045

  Fly   512 FLGDAYYLE---------EGEEVFGHRTYFVVGRRRDFTRTN-----SLSPSMPANATGSSLLLP 562
            .||..|..|         :|:.|    |:::.|...:..:..     .:.|.:.:....|..|.|
  Fly  1046 KLGGGYITEKRGLVNMKGKGDVV----TWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNP 1106

  Fly   563 GAHGASLS--QSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRD 625
            .:...|:.  ......|..|..||.|.. |:.:.||..|  :...||:.|          .||||
  Fly  1107 DSRQPSIQAMHFCGTGSRRQSTVPRAMD-GESTYSLQGS--VRESPRMVS----------KRDRD 1158

  Fly   626 VER---------------------------------------------------GIIHPAAAGIP 639
            .||                                                   |::....|...
  Fly  1159 RERPPINGLGAGHFVGGALLESAQASLSTLNHSETNETNCDMDGGSGGVSGSGSGLVRQPNALHK 1223

  Fly   640 PVIVVRERPKIIITTKSLP--GSLDSDEQPPV---SPPLLPPANPPAAETRSKIKLKVWKIPRFL 699
            |:.:|  ||..||:...||  |..|.|....:   |..|.|.......:...::||...|:.:..
  Fly  1224 PLAMV--RPHRIISAAQLPQLGDNDDDSADTLLRESRSLDPMPMQQLRKRHDRVKLPPSKLSKNN 1286

  Fly   700 KRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQL--NPEETLAFMDNQ----MQNGN 758
            .|..| |..|...|:.:.           |....:|...|::  ||.:.....|::    |::.|
  Fly  1287 SRSLD-TGVSLISGNPNG-----------EVHSSQLDLDNEMTANPVDATDGYDDELGLLMRHDN 1339

  Fly   759 GCGYQQLPVLVESNH--RTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYS 821
            |    |||.|..|..  ..|...:|..|                    .||  ||||
  Fly  1340 G----QLPALRYSGSFPNAQISIVPTGR--------------------SAG--GGGG-------- 1370

  Fly   822 MYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPV-- 884
                                  ||.|. .|.|.:......||    ||..|     .....|:
  Fly  1371 ----------------------GREGG-GSNCAKHLNNNCNG----GVNVE-----DDLESPLLQ 1403

  Fly   885 EQSPLPRPRASTLATGRPTPNSLE--PGPSSTSPCCLPAPGNSV 926
            .|:.|..|....||..:.. :|||  .||....       ||||
  Fly  1404 RQASLSVPPEEMLAHNKRW-HSLEHMDGPGGHG-------GNSV 1439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	70/222 (32%)
		Guanylate_cyc	361..535	CDD:278633	64/188 (34%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	4/10 (40%)
		HNOBA	<835..881	CDD:285003	12/45 (27%)
		CYCc	860..1052	CDD:214485	70/221 (32%)
		Guanylate_cyc	887..1074	CDD:278633	66/212 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454025
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740