Protein Alignment Ac13E and CG32301

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Alignment Length: 1568
• Identity: 298/1568 - (19%)
• Similarity: 484/1568 - (30%)
• Gaps: 689/1568 - (43%)

  Fly   149 YREHRTVTSAVTALLLCGASLAFLTYTGRAFSPLGHFAICLEIVLLIYTALPMPL-------WLG 206
            |.....:.|.:.||||....|.......|.||.:..:...  :::|||...|:..       :||
  Fly   106 YESIAILVSCLMALLLTAMDLILPICYFRPFSLVPSYDHV--VIVLIYLMFPIAFVKNGRAYFLG 168

  Fly   207 ASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLV 271
            .:.::.|.....::..:                              |....:..:.|: ..:|.
  Fly   169 LAVSLFYFGYMALIDKI------------------------------STLDKVWELTAY-GAYLF 202

  Fly   272 GVHVLIMNLVRMRGTFMKVG---------QNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLN-- 325
            .:::|.|.|.|.:...|:.|         |||:.:..::.||.|.:.:|...:...:.|.:.:
  Fly   203 FLNMLCMFLSRFQEYNMRSGILSRYQVVYQNLVFQMAMKEEKALLDSIIPVTLARSLQDAIASHI 267

  Fly   326 EGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLV 390
            |..||.|    :|          ....:.||    |.....||||.||:|.||.:::|.....||
  Fly   268 EEDPSNL----MP----------FTKTRHLF----MEPHPEVSILEADMVDFTGLTTTMEVSDLV 314

  Fly   391 EILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRH 455
            .||::||..||...:.:...:|..|||.|.||:|.|.....||..||...|.||:..|....:|:
  Fly   315 AILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRN 379

  Fly   456 EGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLE 520
            :.:.:|:|||:|.:|.||:|..:.:||:||.||.:.|::||||.|..||||..|...|.:.|..|
  Fly   380 KKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYE 444

  Fly   521 EGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPP 585
            ||                  |.|..|.|                   .|.:|..:...::..:|.
  Fly   445 EG------------------TDTAKLDP-------------------LLQRSNLSTYLIRSRLPN 472

  Fly   586 ASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKI 650
            ......|...              :.|:...:.|.|..:|.|.             |.|:.:..:
  Fly   473 FEDTDDLEDD--------------NFSLNDYRFSFSFSQDYED-------------IQVKAQRDM 510

  Fly   651 IITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSS 715
            |:..:.:|.:                            :::..||.|.:.|.
  Fly   511 ILEVEHMPVN----------------------------RVQTCKIRRPMHRI------------- 534

  Fly   716 SAGHLDKEREREREKEKEELHQHNQLNPEETLAFMD----------NQMQNGNGCGYQQLPVLVE 770
                           .||::::..:.:.|....|..          |:|::          :|::
  Fly   535 ---------------AKEDINEEYRFHLESYYLFTTFRSWRMEWSFNKMRD----------LLMK 574

  Fly   771 SNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQ 835
            .:......            |.:|.:|..:|...||                    :|.....|.
  Fly   575 YSLGMMVF------------AGATIIAMDLLVKSEA--------------------MDYTMLFSL 607

  Fly   836 SRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATG 900
            ....:.|. ...||:.                 :...||
  Fly   608 FLLILLPL-LLASYKK-----------------LWLRGR-------------------------- 628

  Fly   901 RPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQ 965
                                                                      |.|.|.|
  Fly   629 ----------------------------------------------------------RLSPITQ 635

  Fly   966 QIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQ 1030
            ..:.|::..|
  Fly   636 PTFFLSRWFI------------------------------------------------------- 645

  Fly  1031 QLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTL 1095
               |.|||                                 :|:
  Fly   646 ---KASDL---------------------------------IEK--------------------- 653

  Fly  1096 ATPRYNTYIDIFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRR 1160
                     .:||.|.:.:.:...|::|:..||          |||
  Fly   654 ---------SVFVRIPLAIMVLFLLYVMSSETV----------FSC------------------- 680

  Fly  1161 QSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISS-----------WYPWHI 1214
                              |:.|.|                  .|.|:|           :.||.:
  Fly   681 ------------------DIARLE------------------LEIINSELHNLRPQMLCFMPWGV 709

  Fly  1215 CLAVLMAMPVLLIIANF-LLLDL--------EQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNV 1270
            ..||::.:.::|:|... |::.|        ..:.....:|||.       |......|..|.:.
  Fly   710 TYAVVIVLSLMLVIIGIPLIIKLGVGLAILGSHVITVHAYYGFA-------FERSQTTNIGVTSS 767

  Fly  1271 LA---FLAALCFIGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVW 1332
            ||   ::.|. ||.:.|.                                 |.||:  .||...:
  Fly   768 LAHSWYMVAF-FIVVVVR---------------------------------EGYLN--YILKASY 796

  Fly  1333 FLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLK----NTAKYSENHH 1393
            |::..||..:.||          ||:.:.:|    :::.||:|.||||..|    :...|.||..
  Fly   797 FMSMCFEKKHELT----------KVKTRTIK----IIMANILPTHVAEVFKVRRRSDQLYYENFS 847

  Fly  1394 NIAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELL-SRPEFRAVEKIKTIGSTFMAASG 1457
            .:|::||:|        |:|...|..||.|:|:|..||||| :...:..:||||.:|.|::||.|
  Fly   848 QVAVMFATI--------ENYEADKSGLRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACG 904

  Fly  1458 LDPSH-------------------------------------------RGTGDEHIHTLM---EF 1476
            |...|                                           :.|.:|..:|::   ||
  Fly   905 LHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEF 969

  Fly  1477 SIAMQEVVD-------AFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDS 1534
            ::.:..::.       .|.|| .:....|:||:..|.|.|||:|.||.:|||||..||:||||.|
  Fly   970 ALNLLRILRDIRSKGIFFEKD-SKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTS 1033

  Fly  1535 TGLPNRIQVGKDCLPFLTN---RYEFEPRGSVYVKGKDHMEVFLYTTRRDNPLDDDEADKVEQLG 1596
            ||:.:.|.|.:.....|.:   |..:  ||..:|||...:..:|        :|.||....:|..
  Fly  1034 TGVRDGIHVTESTANVLRDFNIRCTY--RGMTFVKGVGQVPTYL--------VDLDENLHFQQHS 1088

  Fly  1597 TKKMEHEG 1604
            .....|:|
  Fly  1089 PDNDSHKG 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	76/217 (35%)
		PHA03307	836..>1015	CDD:223039	11/178 (6%)
		Guanylate_cyc	1388..1575	CDD:425528	73/243 (30%)
CG32301	NP_728724.2	AcyC	51..445	CDD:441717	106/389 (27%)
		Nucleotidyl_cyc_III	283..439	CDD:448371	66/159 (42%)
		AcyC	681..1076	CDD:441717	121/488 (25%)
		Nucleotidyl_cyc_III	841..1076	CDD:448371	74/253 (29%)