Protein Alignment Ac13E and ACXD

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Alignment Length: 1692
• Identity: 348/1692 - (20%)
• Similarity: 553/1692 - (32%)
• Gaps: 740/1692 - (43%)

  Fly    58 PVAFERAAA--------KSW----LDPKFDSPVLEEQY------------QASVFPHVRMRYRFT 98
            |::..|.::        |:|    |..|..:..||:.|            ...:|.||.:....|
  Fly    16 PISLARTSSQAQTVQNEKNWEWSYLVRKCRNLELEDSYDLYMRRLRVGYLSLFIFIHVAVTVIHT 80

  Fly    99 LSYILLCSLMWCLYFVVDGGSEDFWRPISSSFSMLSLVTIMALCFTHWDLYREHRTVTSAVTALL 163
            |   ||.:.....|..||        .::...|.|.:..::.:.|.. :|..:|..|..|.:.|.
  Fly    81 L---LLLTTPEIKYVYVD--------MVAYMCSGLVIWVVLGVNFRS-ELVSKHGWVVYATSWLA 133

  Fly   164 LC-------GASLAFLTYTGRAFSPLGHFAICLEIVLLIYTALPM-----PLWLGASTAISYSIA 216
            :|       |.::...|......:|: :.|..|   ..||..:|:     |..||::....|.|.
  Fly   134 VCVMVLMDIGLNVYHATSHNDILNPI-YDAYTL---YAIYMFMPVPYLLQPFVLGSAVTFCYIIN 194

  Fly   217 FEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLS-VHLVGVHVLIMNL 280
            :..|      .:|.....||.                     ||....:|| |:|:|:...:|..
  Fly   195 YSFV------ITAKDDNQMHS---------------------ILNEAIYLSCVNLLGIFFRLMRD 232

  Fly   281 VRMRGTFMK----VGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPES 341
            :.:|.||:.    |.:|||:|...:.|:.|    :.|::|.::||. |.|...:.::..   .:.
  Fly   233 IALRTTFLDRRQYVEENLLLRYARDQERSL----LLSILPAQIADR-LQEDVKNRIERS---KQQ 289

  Fly   342 HYMRP----RASNDVKSLFR---PFH----MHSMENVSILFADIVGFTRMSSTKTAEQLVEILND 395
            |..:.    |.|.|.::|.|   |.|    :...|:|::|:||:|.:|.:::|...::|||.|:|
  Fly   290 HQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHD 354

  Fly   396 LFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKM 460
            ||.|||.........:|..||||||||:|...|.||||.|||::||.||..:|....:||..:.|
  Fly   355 LFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDM 419

  Fly   461 RVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEV 525
            |:|||:|.||.|::|..:.:||:||.||.:||::|::|...:||:||:|.|.|...|:.|:|.|
  Fly   420 RIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTE- 483

  Fly   526 FGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVG 590
                      :.|:
  Fly   484 ----------KARE--------------------------------------------------- 487

  Fly   591 QLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTK 655
                    .|||...                               ||...::           |
  Fly   488 --------DPVLQKH-------------------------------GIRTFLI-----------K 502

  Fly   656 SLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHL 720
            ||        :.|:..|
  Fly   503 SL--------RAPMHDP------------------------------------------------ 511

  Fly   721 DKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARP 785
               |.|.||::.::|.:.::.|      ||.|.
  Fly   512 ---RRRMRERQVKKLSEASKAN------FMHNS-------------------------------- 535

  Fly   786 VLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRS-DISPFGRSGSY 849
            .||                              ||:.    :..::.:...|. |..|.||.
  Fly   536 TLH------------------------------QYNQ----VRNQAKLEMCRELDKMPIGRI--- 563

  Fly   850 RSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSST 914
                  |.|            ...|..|..|...:|:....|                     :.
  Fly   564 ------QLT------------KVFRRSTRLTQDEIEEETFRR---------------------NI 589

  Fly   915 SPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHR 979
            |.|||
  Fly   590 SSCCL------------------------------------------------------------ 594

  Fly   980 VSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCV 1044
               :|     .|.| .|.|.:                                 |:.|:.|
  Fly   595 ---FF-----RIRN-WEFQYI---------------------------------KEPDVML---- 613

  Fly  1045 RDNARSQRSYLVKPPLRKFS------LYFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTY 1103
                             |:|      :|.....::  ..||..|:                :..|
  Fly   614 -----------------KYSIALAWVIYMGLLTIQ--LLSKDARY----------------HYWY 643

  Fly  1104 IDIFVGIAVYLCISVS-------LFLMTQNTVSPSFRLWVTLFSCFTGIQ------VFALFLFTR 1155
            ||....|.:.:.:.||       :::...:..||:.||...||.....:|      |...||...
  Fly   644 IDGTTIILLTMLLIVSWYKKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLIIF 708

  Fly  1156 QMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHI--CLAV 1218
            ..|.......|.   .|......||:           |.::       |.:..::||.:  |:.:
  Fly   709 SYCAVAIMQVVG---CSSDEDYADLD-----------PTYD-------ERVQCFHPWILTNCMTL 752

  Fly  1219 LMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIA 1283
            ::.|       :||...:.          |:|..|                    .:||..||.|
  Fly   753 VIGM-------SFLFTRIP----------FIIKSC--------------------FSALIMIGYA 780

  Fly  1284 VSQLMVYSHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILV---LVWFLNREFEIGYRLT 1345
            |  |:|...|...........||..:           |..:||:::   :...:.|:.|.
  Fly   781 V--LVVSEFNFIYANSPSTNVNFNAK-----------YSHILLMIITFGIFHLMERQTEF----- 827

  Fly  1346 FYGNAVANQD-KVRVQNMKNQAD---------MLLHNIIPKHVAE-HLKNTAK---YSENHHNIA 1396
                 :|..| ..:.|.:|.|.|         :||.||:|.|||: :|.|..:   |.|.:.|:|
  Fly   828 -----IAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVADFYLSNQLQNELYYEEYDNVA 887

  Fly  1397 IIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSR-PEFRAVEKIKTIGSTFMAASGLDP 1460
            ::||||.||    |...:|    ||||||:|.|||::|:: .:...|||||....|:|||.|||.
  Fly   888 VMFASIKNF----DTDKIG----LRVLNEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLDV 944

  Fly  1461 S---------------------------------------------------------------- 1461
            |
  Fly   945 SRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALDLDLERGQYEGNVI 1009

  Fly  1462 ---------HRG-TGDEHIHTLMEFSIAMQEVVDAFNKDLLEFNL-------ILRIGMNIGDVTA 1509
                     |.| :.:|.:..:.||::.:...:..||.:.::...       :||||::.|...|
  Fly  1010 TSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAMA 1074

  Fly  1510 GVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKD-CLPFLTNRYEFEPRGSVYVKGKDHMEV 1573
            ||:|.||.:|||||:.||:||||||||:|.:|||.:: .|.......:...||..:|||:.::..
  Fly  1075 GVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCNYRGMTFVKGRGNIPT 1139

  Fly  1574 FL 1575
            ::
  Fly  1140 YI 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	86/226 (38%)
		Guanylate_cyc	361..535	CDD:278633	74/173 (43%)
		CYCc	1362..1556	CDD:214485	87/289 (30%)
		Guanylate_cyc	1388..1575	CDD:278633	79/269 (29%)
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	64/289 (22%)
		CYCc	254..476	CDD:214485	86/229 (38%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	80/293 (27%)
		CYCc	856..1117	CDD:214485	84/268 (31%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	79/272 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6595
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.790