Protein Alignment Ac13E and Ac3

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Alignment Length: 1577
• Identity: 362/1577 - (22%)
• Similarity: 557/1577 - (35%)
• Gaps: 618/1577 - (39%)

  Fly   148 LYREHRTVTSAVTALLLCGASLAFLTYT--GRAFSP---LGHFAICLEIVLLIYTALPMPL-WLG 206
            |.|.|:.:...|...|...:.|.|..|.  ..:|||   || :||.|.  .|:|..||:.| :||
  Fly   124 LRRFHQILLIIVPRALWLLSILHFTVYVILQPSFSPRDLLG-WAILLN--FLVYVTLPLQLIFLG 185

  Fly   207 AST-AISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHL 270
            .|. .|:|.|           |.::..|..|       ...:.:|...:|.:||      .:..|
  Fly   186 LSIGCITYFI-----------CLSLPVGYSH-------WDSLLSNQLAANAVLI------ATAAL 226

  Fly   271 VGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAG 335
            :|:....|...:.:..|::..::|.|:..:|.:...:|:::.||:|..||..:..:.|.|..:|
  Fly   227 IGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEA- 290

  Fly   336 GLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERF 400
                                |:..:|...||||||:|||||||.:|||.:|:.||::||:||.||
  Fly   291 --------------------FKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARF 335

  Fly   401 DDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVH 465
            |.|.......:|..|||||||:||.|:.|.|||:.||.|||.|:.|::....:.:..|.||||:|
  Fly   336 DRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIH 400

  Fly   466 TGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLG-----DAYYLEEGEE- 524
            ||.||.||:|.|:.:|||:|.||.||||||||||..:||||.:|.:||.     :|.:.|:.||
  Fly   401 TGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREEL 465

  Fly   525 --VFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPAS 587
              :.|.:|||:....:.|                                             ||
  Fly   466 LRIAGLKTYFITKVVKAF---------------------------------------------AS 485

  Fly   588 PVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIII 652
            |..:                              :..:.:..|.||...|....||
  Fly   486 PCAK------------------------------KINETQAEIAHPNPNGSTTDIV--------- 511

  Fly   653 TTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSA 717
                      |||..                                   .|.|
  Fly   512 ----------SDEDD-----------------------------------NDAT----------- 520

  Fly   718 GHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPA 782
                                   |:.||.||  .|.:.||:     |:.:.|.::...|
  Fly   521 -----------------------LDDEELLA--QNSVSNGH-----QIGIAVTADEEEQ------ 549

  Fly   783 ARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSG 847
                                                        :.:.::..:.:.::
  Fly   550 --------------------------------------------VKLENFKQRLKDEL------- 563

  Fly   848 SYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPS 912
                                 |..:|....:
  Fly   564 ---------------------VTRDGHENLT---------------------------------- 573

  Fly   913 STSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQ 977
                                                 ||:.|....:...: :|:||:.:...|
  Fly   574 -------------------------------------KDTNIFLRFKNPQL-EQLYAVYREPYS- 599

  Fly   978 HRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIR 1042
                                   .|||                :|..|..|:..|
  Fly   600 -----------------------SLPL----------------LAALLVQCIDVL---------- 615

  Fly  1043 CVRDNARSQRSYLVKPPLRKFSLYFKS-------------RQLERDFRSKAHRFGAENETEGPPT 1094
                     .||||.|   :.:|:|.:             ..|...|.....:|..:
  Fly   616 ---------YSYLVLP---RSTLHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVD-------- 660

  Fly  1095 LATPRYN--TYIDIFVGIAVYLCISVS---------LFLMTQNTVSPS-FRLWVTLFSCFTGI-- 1145
             .:.|:|  |::.....|.:.|.|..|         .|:.|::.||.| |.:..:|.|....:
  Fly   661 -VSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVE 724

  Fly  1146 -QVFALFL----FTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEA 1205
             .|.|..|    |..||                           |.|.|         .:|:.
  Fly   725 GMVTAEHLLPASFVEQM---------------------------RDAVP---------TERVL-- 751

  Fly  1206 ISSWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNV 1270
                ||.:              ::||               |.||.:.|......|.|...:  :
  Fly   752 ----YPSY--------------LSNF---------------GVLILIAIAVIAQLTHLTKIL--L 781

  Fly  1271 LAFLAAL-CFIGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVL-VWF 1333
            |..:||| |:..|.:.| .:|:.....:.|...::.:...             .|||:..| :..
  Fly   782 LLSIAALHCYFNIFIMQ-DLYALEDDFEHQPIISTRYAAS-------------GLLLVAALALST 832

  Fly  1334 LNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEH-LKNTAK-----YSENH 1392
            |.|..:...|:.|.......:.|....:|:.:.:.|::|::|.||||| :|||.:     ||:::
  Fly   833 LARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSY 897

  Fly  1393 HNIAIIFASIVNFNEMYDESYLG--GKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAA 1455
            ..:.::|||:.||::.|.|..:.  |.|.||.|||:|.|||.||..|:|:.:.||||||||:|||
  Fly   898 AEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAA 962

  Fly  1456 SGLDPSHRGTGD-------EHIHTLMEFSIAMQEVVDAFNKDLLEFN-LILRIGMNIGDVTAGVI 1512
            ||::.......|       .|:..|:||::.::..:.:.|:.  .|| .:|::|:|.|.:|||||
  Fly   963 SGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQ--SFNHFVLKMGINHGPITAGVI 1025

  Fly  1513 GTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKD-CLPFLTNRYEFEPRGSVYVKGKDHMEVFLY 1576
            |..|.:|||||:.|||||||:|||....|||.:: |.......|.|..||.|.||||..:..|.
  Fly  1026 GARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFY- 1089

  Fly  1577 TTRRDNPLDDDEADKVEQLGTKKMEHEGRDEDVVQGEQQAEDKD-----------EEEEEEEEDD 1630
                   |........|.:.:..:...|:|...|:...:.|..|           |:..|.::|.
  Fly  1090 -------LQGKSQSSAEPVASGVVVLNGQDSSAVESTSELEASDIKMPLLKMNGPEQSLEIDQDR 1147

  Fly  1631 DLHSSETTTLFKSQESL 1647
            .|.:...     .|||:
  Fly  1148 SLRNDSA-----GQESV 1159

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	98/220 (45%)
		Guanylate_cyc	361..535	CDD:278633	95/181 (52%)
		CYCc	1362..1556	CDD:214485	87/210 (41%)
		Guanylate_cyc	1388..1575	CDD:278633	84/197 (43%)
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	45/184 (24%)
		CYCc	256..453	CDD:214485	98/217 (45%)
		Guanylate_cyc	294..476	CDD:278633	94/181 (52%)
		CYCc	860..1071	CDD:214485	88/212 (42%)
		Guanylate_cyc	892..1092	CDD:278633	86/209 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840