Protein Alignment Ac13E and ACXC

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Alignment Length: 1614
• Identity: 339/1614 - (21%)
• Similarity: 556/1614 - (34%)
• Gaps: 649/1614 - (40%)

  Fly    57 LPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVR-MRYRFTLSYILLCSLMWCLYFV----VD 116
            |..|.||....|:|..|.....|||:|:   :..|| |....|:.|:|...|......:    |.
  Fly    23 LDYANERLWEHSYLREKCKELNLEEEYR---YYQVRLMVSNLTIFYVLFIILAMSFLTIELLYVQ 84

  Fly   117 GGSEDFWRPISSSFSMLSLVTIMALCFTHWDLYREHRTV---TSAVTALLLCGASLAFLTY---- 174
            ..:..|:..:....|.:.::|::::.|....:.| ||.|   :|.::..|:....:..::|
  Fly    85 HYNAVFFNFVIRVVSTILVLTVLSINFCEKFVSR-HRWVMIASSVLSVYLVVLTDIVMISYHFYK 148

  Fly   175 ----TGRAFSPLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPM 235
                ...:|..   |.:|     :||..||:|...||:...| |::...|:..           |
  Fly   149 NDWPLNTSFDV---FTLC-----MIYMFLPIPSIKGAALLAS-SVSLIYVAFF-----------M 193

  Fly   236 HGGGGAAGGSGMEANGDPSNR------ILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNL 294
            |         .:..|...::|      ::...|:.:|..:::|:...|||...:|.:|
  Fly   194 H---------SLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTMVRASF------- 242

  Fly   295 LVRRQLEMEKQ------LKEK-MIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDV 352
            |.|.|..||:.      |:|. ::.|::||::|.. :.|...|.:......|:...|.||.:..
  Fly   243 LDRHQFIMEETWLRHALLQESILLDSILPPQIAKP-VQEKIKSKITQSENSPDRFQMGPRTTES- 305

  Fly   353 KSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGD 417
               |....:|  .:||||:||:|.:|.:::|.|...||::|:||:.|||...|....::|..|||
  Fly   306 ---FMAIQIH--PDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGD 365

  Fly   418 CYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFD 482
            |||||:|...|..|||.|||.:|:.||..::...|:|...:.||:|||:|::|.||:|..:::||
  Fly   366 CYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFD 430

  Fly   483 VWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRDFTRTNSLS 547
            :|..||.:||.:||:|:|..||:|..|.|.|..|                      |:|
  Fly   431 IWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPA----------------------DYT------ 467

  Fly   548 PSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLS 612
                        :|.|...|   ||                          .|||.
  Fly   468 ------------ILSGTQKA---QS--------------------------DPVLQ--------- 482

  Fly   613 MKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPA 677
                             .||                     |..|.|.:
  Fly   483 -----------------YIH---------------------TYLLTGQV---------------- 493

  Fly   678 NPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLN 742
               |.|:             |:         :|.||..|:..|:
  Fly   494 ---ARES-------------FI---------TSIGGVRSSSVLE--------------------- 512

  Fly   743 PEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAG 807
                                      |:|..|                          :||..
  Fly   513 --------------------------VKSIDR--------------------------IRSSR-- 523

  Fly   808 VSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAE 872
                     |.|.||.|:                       :|.:......||:|
  Fly   524 ---------PSQSSMTDE-----------------------FREEFRNMPVGGIN---------- 546

  Fly   873 GRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHS 937
                                                    ..||||
  Fly   547 ----------------------------------------LNSPCC------------------- 552

  Fly   938 RQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGL 1002
            |::.:.....::::.||...:.:.|..:..|.        |:....|.|
  Fly   553 RRTRLDTHKKTQREIGIFCAAFKDSSLEWNYL--------HQPDFIFKS---------------- 593

  Fly  1003 PLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSL-- 1065
                           |..:|..:..||..::          :..|..|..:.:|...:..|.|
  Fly   594 ---------------SMLLAWGIGCCLIYIQ----------IVTNNFSCTACIVVDLVTFFFLTS 633

  Fly  1066 -----------YFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAVYLCISVS 1119
                       ::||.:.|  ||.    :|.                           |.|::..
  Fly   634 LLCLAWYKNVCWWKSGRYE--FRI----YGK---------------------------YSCMAFH 665

  Fly  1120 LFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQ--SGSNVSNRFRSKSTTSEDLER 1182
            :|...|::|  |.|:.|.|...|:...|.:|.:..   |.|.  ..|.:.::..
  Fly   666 IFEKIQHSV--SLRITVYLGILFSYYAVISLIMLN---CDRDMYELSYIESKIY----------- 714

  Fly  1183 DERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYG 1247
                       |:|...|..|      :||              :..|.:.|.|    ...|.:.
  Fly   715 -----------HYEMDRDTCF------HPW--------------VFTNMISLIL----GISYTFA 744

  Fly  1248 FLIF-VCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRSDQQQDQEASNFIQEIK 1311
            .:.| :.||..|      |   ..||:|..:.|     ....::.|:.:...
  Fly   745 RIPFGLKIVISC------C---ETLAYLLIVFF-----QFAFIFQHSATTTP------------- 782

  Fly  1312 WFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQA-DMLLHNIIP 1375
             |....:...|.:.::|:.::...|:.|...::.:..| |..|:|.:..::.||: .:||:||:|
  Fly   783 -FMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLN-VDLQNKQKAADLTNQSIIILLNNILP 845

  Fly  1376 KHVAE-HLKNTAK---YSENHHNIAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSR 1436
            .||.: :|.:.||   |.||:..::::||.::||......        |||||::|..||.||:.
  Fly   846 SHVVDLYLNSLAKHELYYENYRMVSVMFAMLINFPMNLPS--------LRVLNDIITQFDRLLTA 902

  Fly  1437 -PEFRAVEKIKTIGSTFMAASGLD-------------------------PSHRGT---------G 1466
             .|:..|||||.:|.|:|||.|||                         .:||.|         .
  Fly   903 YREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNN 967

  Fly  1467 DEHIHTLMEFSIAMQEVVDAFNK----DLLEFNLI---LRIGMNIGDVTAGVIGTSKLYYDIWGD 1524
            ||.:..:..|::.:...:.|.|:    ...|.:|.   :.||::.|::.|||:|.|:.:|||||:
  Fly   968 DEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGN 1032

  Fly  1525 AVNVASRMDSTGLPNRIQVGKDCLPFLTNRYEFE----PRGSVYVKGKDHMEVF 1574
            .||:||||:|||||..|||.::....|   .||:    .||..:|||:..:..:
  Fly  1033 PVNMASRMESTGLPGHIQVTEESAKIL---QEFDIKCIYRGMTFVKGRGDIPTY 1083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	85/222 (38%)
		PHA03307	836..>1015	CDD:223039	16/178 (9%)
		Guanylate_cyc	1388..1575	CDD:425528	76/233 (33%)
ACXC	NP_609593.1	Nucleotidyl_cyc_III	307..466	CDD:448371	70/182 (38%)
		Nucleotidyl_cyc_III	861..1085	CDD:448371	76/234 (32%)