Protein Alignment Ac13E and rut

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_511156.2
• Gene: rut / 32406
• FlyBaseID: FBgn0003301
• Length: 2248
• Species: Drosophila melanogaster
• Alignment Length: 1738
• Identity: 402/1738 - (23%)
• Similarity: 619/1738 - (35%)
• Gaps: 607/1738 - (34%)

  Fly    73 KFDSPVLEEQYQASVFPHVRMRYRFTLS------------YILLCSLMWCLYFVVDGGSEDFWRP 125
            :|::..||..||           |:||.            ..:||.:|..|....:..:.  :..
  Fly    17 RFENDELECLYQ-----------RYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAAT--FHN 68

  Fly   126 ISSSF--SMLSLVTIMALCFTHWDLYREHRTVTSAVTALL----LCGASLAFLTYTGRAFSPLGH 184
            |.::.  .:.::|.::..|    .:.::|...|.....||    :|..|:..|   |..| |:..
  Fly    69 IFNAIVCGLFAVVLVLLQC----SVIKDHHLPTLCYGILLFTASICVVSMPTL---GSVF-PVDT 125

  Fly   185 FAICLE-------IVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAA 242
            ..:..|       :|.|.|..:|:.:|    .|:::.||...| |:.:....|....:.
  Fly   126 KEVMAEGVWQIVFVVFLAYAMMPLQIW----EAVAFGIALPSV-HISLTVYKIFTDALR------ 179

  Fly   243 GGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLK 307
               .:|.|.      ||..|:..:.|::.|:.|.||.....|.||:.....:..|.:::.|.:..
  Fly   180 ---YLEYNQ------LIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKL 235

  Fly   308 EKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFA 372
            |:::.||:|..||..:.|:                .:.|     |...|...::...||||||||
  Fly   236 ERLLLSVLPQHVAMQMKND----------------ILSP-----VAGQFHRIYIQKHENVSILFA 279

  Fly   373 DIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCV 437
            ||||||.:||..:|::||.:||:||.|||.|...:.|.:|..||||||||||.||||.|||.|.|
  Fly   280 DIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHAKCAV 344

  Fly   438 EMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQ 502
            ||||.||||:..........:.||||:|||.||||::|.|:.:||||||||:|||.|||.|:|.:
  Fly   345 EMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGR 409

  Fly   503 VHISQETSSFLGDAYYLEEGE--------EVFGHRTYFVV--GRRRDFTRTNSLSPSMPANATGS 557
            ||:::.|...|...|.:|.|.        ...|..|:|:|  ..||.....|:|.
  Fly   410 VHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKPLMLNTLG---------- 464

  Fly   558 SLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSR 622
               :..|.|:....|..|||.|         |.||..::..|
  Fly   465 ---VRSAIGSRRKLSFRNVSNV---------VMQLLHTIKFS----------------------- 494

  Fly   623 DRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSK 687
                            .||      |...|.|.|.|.:..:
  Fly   495 ----------------EPV------PFSNIATGSFPSAASA------------------------ 513

  Fly   688 IKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDN 752
                             |....|.||....|                                ..
  Fly   514 -----------------LGGGVSVGGGGGGG--------------------------------GG 529

  Fly   753 QMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALA-SSVLRS---PEAGVSGGGG 813
            .:..|:.|......|.|......:.:.:   :.:||.......:. .||:.|   .::|:|||||
  Fly   530 GVARGSTCEANSGNVQVSEKGSRKVIRL---QKILHATPPPHGMGYGSVVGSGGGVDSGISGGGG 591

  Fly   814 CCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTS 878
            |.|                                          ||:.|.|    |.:...||:
  Fly   592 CVS------------------------------------------GGIAGGG----GVQVTVGTN 610

  Fly   879 QTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSIC 943
                       |...|||::.                               |....|
  Fly   611 -----------PNSTASTISR-------------------------------IHRHNH------- 626

  Fly   944 PSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQP 1008
                       |:|..:|.:..:   ..:....:|.|:.:. ..|:.::..       |..|:
  Fly   627 -----------KNNKSQSKVADK---FKRPFRKRHSVAAHH-QPTNRVNRF-------LSQAI-- 667

  Fly  1009 PPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARS---QRSYLVKPPLRKFSLYFKSR 1070
                                                  ||||   .:|..|.    :.:|.|:..
  Fly   668 --------------------------------------NARSVDCDKSEHVD----RLTLRFRQS 690

  Fly  1071 QLERDFRSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAVYLCISVSLFLM---TQNTVSPSF 1132
            .:||::    |:                      |..:|....:..|:.|.::   .|.|..|..
  Fly   691 DMEREY----HK----------------------DFDLGFTTAMGCSLLLLILGAALQVTALPRT 729

  Fly  1133 RLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFES 1197
            .:.:.|| .|..|.|.|:.:..
  Fly   730 LILLLLF-LFAFIWVSAILMLL------------------------------------------- 750

  Fly  1198 CADRIFEAISSWYPWHI--CLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCI------ 1254
            .|.|:     .|..|.|  ..::.||:.:..:|   |:..:.|:.         :|.|:
  Fly   751 LAVRL-----KWIIWDISESFSLRMAITIFTVI---LIYSVGQVN---------VFTCVSDHPCS 798

  Fly  1255 ----VHFCNFTQLNCWVRNVLAFLAALCFIGIAV--------SQLMV------------YSHNRS 1295
                ..|.|.:...|.:...::..||..|:.::|        ..|:|            .||...
  Fly   799 GNGTTSFQNDSHRKCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNI 863

  Fly  1296 DQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQ 1360
            .:..|...:..|       ..|:.....:.:.::.:....|..|...||.|.....|:|:|..:.
  Fly   864 FECYDNRVNASI-------PLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMD 921

  Fly  1361 NMKNQADMLLHNIIPKHVAEHL------KNTAKYSENHHNIAIIFASIVNFNEMYDE--SYLGGK 1417
            .::.....:|||::|.|||.|.      .|...|.:::..:.:||||:.||||.|.|  ....|.
  Fly   922 VLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGL 986

  Fly  1418 EFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHR------GTGDEHIHTLMEF 1476
            |.||:|||:|.||||||....||.::||||:|||:||..||.|.::      .:...|:..|:|:
  Fly   987 ECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEY 1051

  Fly  1477 SIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRI 1541
            ..||:..:...|..... |.:||:|:|||.|.|||||..|..|||||:.|||||||||||:|...
  Fly  1052 VKAMRHSLQEINSHSYN-NFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYS 1115

  Fly  1542 QVGKDCLPFLT-NRYEFEPRGSVYVKGKDHMEVFLYTTRRDNPLDDDEAD--------------- 1590
            ||.::.:..|. :.:||..||::.||||..|..:......:..|:.:..:
  Fly  1116 QVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFLCDSGNKSLNGEVRNAMSLPQSLHAPDYYM 1180

  Fly  1591 KVEQLGTKKMEHE--GRDEDVVQGEQQAEDKDEEEE-----EEEEDD-------------DLHSS 1635
            ||.|....::..:  .:.|:   |...|.:..||::     :.::.|             .||..
  Fly  1181 KVSQFPENRVNTDTYSKKEN---GHLYAGNGVEEQQLLLQHQHKQHDPLPLPAPPPPVHHHLHQQ 1242

  Fly  1636 ETTTL---FKSQESLQANGGSHLAPNAAATSHTHTITLTNNNNHNSSN 1680
            :...|   .:.|....||||   .||..          .|.|.||..:
  Fly  1243 QQQRLNSKLQKQPIFMANGG---LPNIR----------ENGNGHNGEH 1277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	100/215 (47%)
		Guanylate_cyc	361..535	CDD:278633	96/183 (52%)
		CYCc	1362..1556	CDD:214485	88/208 (42%)
		Guanylate_cyc	1388..1575	CDD:278633	88/195 (45%)
rut	NP_511156.2	AC_N	<17..255	CDD:292831	59/294 (20%)
		CYCc	230..425	CDD:214485	100/215 (47%)
		Guanylate_cyc	266..438	CDD:278633	92/171 (54%)
		DUF1053	624..696	CDD:283888	19/144 (13%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	28/217 (13%)
		CYCc	924..1134	CDD:214485	90/210 (43%)
		Guanylate_cyc	954..1151	CDD:278633	88/197 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910