DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and Adcy9

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	XP_008765747.1	Gene:	Adcy9 / 302950	RGDID:	1304747	Length:	1373	Species:	Rattus norvegicus

Alignment Length:	1634	Identity:	491/1634 - (30%)
Similarity:	715/1634 - (43%)	Gaps:	552/1634 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLYFVVDGGSED 121
            ||..||||::: |.||||||..|||......||..:.|:|:.|.|:....|:|.:||.|
  Rat    79 LPQLFERASSR-WWDPKFDSVNLEEACLERCFPQTQRRFRYALFYVGFACLLWSIYFAV------ 136

  Fly   122 FWRPISSSFSMLSLVTIM---ALC----------FTHWDLYREHRTVTSAVTALLLCGASLA--F 171
                     .|.|.|.:|   |||          ||...||..|...||....||:...:||  |
  Rat   137 ---------HMRSKVIVMVVPALCFLVVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQF 192

  Fly   172 LTYT---GRAFSP---------------LGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFE 218
            ..:|   ||..||               :|.|::|:|::.|:||.:.:||:|.....:.||:.||
  Rat   193 QVWTPLSGRVDSPNHTLTAKAADTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLFLGVVYSVLFE 257

  Fly   219 MVSHMVIGCSAIH-----------GGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVG 272
            ...:        |           .|.:|..                   |:.|.:.|:.:|.:|
  Rat   258 TFGY--------HFRNEDCFPSPDPGALHWE-------------------LLSRALLHVCIHAIG 295

  Fly   273 VHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGL 337
            :|:.:|:.||.|.||:||||:::..:.||:||.|||:|||||||..:||.|:.:|...
  Rat   296 IHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEE------- 353

  Fly   338 PPESHYMRPRASNDVKS------------LFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLV 390
              ..:.::..|::..|:            .||||.|..:|.||||||||||||:||:.|:|..||
  Rat   354 --SENSVKRHATSSPKNRKKKASIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALV 416

  Fly   391 EILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRH 455
            .:|||||.|||.||..:.||||||||||||||:||||||||||.||:|||||||.|:..|..::.
  Rat   417 GLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKK 481

  Fly   456 EGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLE 520
            |.|.||||||||||||||:|.||.|||||||||:|||.||..|...:||||:.|:.:|.|.|.:|
  Rat   482 EMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME 546

  Fly   521 EG------------EEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSA 573
            :|            :::.|.:||.:.|:|           :..::.:.:..||.|
  Rat   547 DGRVMERLGQSVVADQLKGLKTYLISGQR-----------AKESHCSCAEALLSG---------- 590

  Fly   574 TNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGI 638
              ...:..:...:.|.||.::|
  Rat   591 --FEVIDDSRVSSGPRGQGTAS------------------------------------------- 610

  Fly   639 PPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFE 703
                               |||: ||                .|:|              :|.|:
  Rat   611 -------------------PGSV-SD----------------LAQT--------------VKTFD 625

  Fly   704 DLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVL 768
            :|....|||                                  :.|....
  Rat   626 NLKTCPSCG----------------------------------ITFAPKS--------------- 641

  Fly   769 VESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGG---GGCCSPGQYSMYDDIIDVR 830
                                                |||..||   .||..
  Rat   642 ------------------------------------EAGAEGGAVQNGCQD-------------- 656

  Fly   831 SYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAP-------PVEQSP 888
                                                     |.:|.|..|:.       |:...|
  Rat   657 -----------------------------------------EPKASTKVTSSWLLFLSVPLLAHP 680

  Fly   889 LPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSR----QSSICPSATSR 949
               |:||             .||:|.:.           .|.:.||...:    |:|:|..
  Rat   681 ---PKAS-------------GGPNSKTQ-----------NGLLSPPAEEKLTNSQTSLCEI---- 714

  Fly   950 KDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLM 1014
                ::...|.:.:     :|:|:|:                          |||.
  Rat   715 ----LQEKGRWAGV-----SLDQSAL--------------------------LPLR--------- 735

  Fly  1015 PACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSK 1079
                          .:.:|:::|...:..::::: ..:.|..|||:.:|||.|..::||:.:|:.
  Rat   736 --------------FKNIREKTDAHFVDVIKEDS-LMKDYFFKPPISQFSLNFLDQELEQSYRAS 785

  Fly  1080 AHRFGAENETEGPP--TLATPRYNTYIDIFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFSCF 1142
            ..    |...:..|  |.|:..:::.:|:|:...|:|.:|::.||....|.:|.....:.:|...
  Rat   786 YQ----EEVIKNSPVKTFASATFSSLLDVFLSTTVFLILSITCFLKYGATATPPPPAALAVFGAD 846

  Fly  1143 TGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAIS 1207
            ..::|.:|.:..|.:                 ...||:               .:|..|:.|.|:
  Rat   847 LLLEVLSLIVSIRMV-----------------FFLEDV---------------LTCTKRLLEWIA 879

  Fly  1208 SWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLA 1272
            .|.|.|...|:|:::|.|.:.:: :..:.|....|....|..:.|.:||:|||.||:.|:|:.||
  Rat   880 GWLPRHCIGAILVSLPALAVYSH-ITSEFETNINFTMLTGSAVLVAVVHYCNFCQLSSWMRSSLA 943

  Fly  1273 FLAA-----LCFIGIAVSQLMVYSH---------------NRSDQQQDQEASNFIQEIKWFQDYH 1317
            .|..     |.:|.:.....:|.|.               |.|..|..:..::.|.:
  Rat   944 TLVGAGPLLLLYISLCQDSSIVMSPLDTAQNFSASERSPCNSSVLQDGRRPASLIGK-------- 1000

  Fly  1318 VEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHL 1382
             |:.|...|:|:||||||||||:.|||.::|:..|:..:.::|:|::|||.||.||||.||||.|
  Rat  1001 -ELILTFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQL 1064

  Fly  1383 KNTAKYSENHHNIAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKT 1447
            |.:..||:||.:..:||||||||:|.|:|:|.||||..|||||||||||||||:|::.::|||||
  Rat  1065 KVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNSIEKIKT 1129

  Fly  1448 IGSTFMAASGLDPS---HRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTA 1509
            ||:|:||||||:.:   ..|...||:..|.||:..|..|||.||.::|.||..||:|.|.|.:||
  Rat  1130 IGATYMAASGLNTAQCQEGGHPQEHLRILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTA 1194

  Fly  1510 GVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNR-YEFEPRGSVYVKGKDHMEV 1573
            |||||:||.||||||.||:|||||:||:..||||.::....|:.. |:|:.||:|.||||..|:.
  Rat  1195 GVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKT 1259

  Fly  1574 FLYTTRRDN 1582
            :||....||
  Rat  1260 YLYPKCTDN 1268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	128/227 (56%)
		Guanylate_cyc	361..535	CDD:278633	112/185 (61%)
		CYCc	1362..1556	CDD:214485	115/197 (58%)
		Guanylate_cyc	1388..1575	CDD:278633	109/190 (57%)
Adcy9	XP_008765747.1	DUF2339	<118..>193	CDD:287113	25/89 (28%)
		CYCc	326..544	CDD:214485	128/226 (57%)
		Guanylate_cyc	385..573	CDD:278633	113/187 (60%)
		CYCc	1044..1244	CDD:214485	116/199 (58%)
		Guanylate_cyc	1070..1261	CDD:278633	109/190 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352672
Domainoid	1	1.000	228	1.000	Domainoid score	I2408
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H868
Inparanoid	1	1.050	738	1.000	Inparanoid score	I566
OMA	1	1.010	-	-		QHG49383
OrthoDB	1	1.010	-	-		D207369at33208
OrthoFinder	1	1.000	-	-		FOG0006877
OrthoInspector	1	1.000	-	-		oto96337
orthoMCL	1	0.900	-	-		OOG6_106616
Panther	1	1.100	-	-	LDO	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5766
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910