DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and GUCY2D

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_000171.1	Gene:	GUCY2D / 3000	HGNCID:	4689	Length:	1103	Species:	Homo sapiens

Alignment Length:	344	Identity:	96/344 - (27%)
Similarity:	157/344 - (45%)	Gaps:	82/344 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 LIMNLVRMRGTFMKVGQNLLVRR--QLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLP 338
            :|.:::||...:....::|:..|  :||:|||..::::..::||.||:.|..          |.|
Human   816 IIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKT----------GTP 870

  Fly   339 PESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDL 403
            .|..|                    .|.|::.|:||||||.:|:.....::|::||||:..||.:
Human   871 VEPEY--------------------FEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAI 915

  Fly   404 CSLSGCEKISTLGDCYYCVSGCPEPRAD-HAICCVEMGLGMIDAMRCFDAQRH---EGVKMRVGV 464
            .......|:.|:||.|...||.|:.... ||.....|.|.::.|:..| ..||   ..|::|:|:
Human   916 IGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTF-RMRHMPEVPVRIRIGL 979

  Fly   465 HTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSF---LGDAYYLE------ 520
            |:|..:.|:||....::.::.:.|:.|::|||:|.|.::|::..|...   |...|.:|
Human   980 HSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTE 1044

  Fly   521 ---EGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPN 582
               :|.|    .|:::||||    ..|...|..|....|||     .||.||.:
Human  1045 LKGKGAE----DTFWLVGRR----GFNKPIPKPPDLQPGSS-----NHGISLQE----------- 1085

  Fly   583 VPP--------ASPVGQLS 593
            :||        |.| ||.|
Human  1086 IPPERRRKLEKARP-GQFS 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	63/222 (28%)
		Guanylate_cyc	361..535	CDD:278633	56/189 (30%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
GUCY2D	NP_000171.1	PBP1_sensory_GC_DEF-like	55..431	CDD:380594
		PK_GC-2D	536..811	CDD:270945
		HNOBA	<820..865	CDD:369471	13/44 (30%)
		CYCc	846..1036	CDD:214485	62/220 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1103		15/54 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900