DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and GUCY2F

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001513.2	Gene:	GUCY2F / 2986	HGNCID:	4691	Length:	1108	Species:	Homo sapiens

Alignment Length:	341	Identity:	91/341 - (26%)
Similarity:	153/341 - (44%)	Gaps:	72/341 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 LIMNLVRMRGTFMKVGQNLLVRR--QLEMEKQLKEKMIHSVMPPKVADMLLNEG---GPSGLDAG 335
            :|.:::||...:....::|:..|  :||:|||..||::..::||.||:. |.:|   .|.|.|.
Human   820 IIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAES-LKKGCTVEPEGFDL- 882

  Fly   336 GLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERF 400
                                           |::.|:||||||.:|:.....::|::||||:..|
Human   883 -------------------------------VTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLF 916

  Fly   401 DDLCSLSGCEKISTLGDCYYCVSGCPEPRAD-HAICCVEMGLGMIDAMRCFDAQRH---EGVKMR 461
            |.:.......|:.|:||.|...||.|:.... ||.....|.|.::.::..| ..||   ..|::|
Human   917 DAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTF-KMRHMPEVPVRIR 980

  Fly   462 VGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVF 526
            :|:|:|.|:.|:||....::.::.:.|:.|::|||:|.|.::|:|..|.:.|.:   |.||.||
Human   981 IGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQN---LSEGYEV- 1041

  Fly   527 GHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQ 591
                 .:.||           ..:....|..:..|.|..|         .....|..||....||
Human  1042 -----ELRGR-----------TELKGKGTEETFWLIGKKG---------FMKPLPVPPPVDKDGQ 1081

  Fly   592 LSSSLNPSPVLSMRPR 607
            :...|.|..:.:.:.|
Human  1082 VGHGLQPVEIAAFQRR 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	65/222 (29%)
		Guanylate_cyc	361..535	CDD:278633	56/177 (32%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
GUCY2F	NP_001513.2	PBP1_sensory_GC_DEF_like	54..435	CDD:107366
		ANF_receptor	75..412	CDD:279440
		PKc_like	545..815	CDD:304357
		HNOBA	<824..869	CDD:285003	15/45 (33%)
		CYCc	848..1040	CDD:214485	68/228 (30%)
		Guanylate_cyc	875..1062	CDD:278633	63/239 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810