DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ac13E and Adcy8

DIOPT Version :10

Sequence 1:NP_001259575.1 Gene:Ac13E / 32485 FlyBaseID:FBgn0022710 Length:1703 Species:Drosophila melanogaster
Sequence 2:NP_058838.1 Gene:Adcy8 / 29241 RGDID:2036 Length:1248 Species:Rattus norvegicus


Alignment Length:1553 Identity:354/1553 - (22%)
Similarity:546/1553 - (35%) Gaps:569/1553 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   136 VTIMALCFTHWD----LYREHRTVTS--AVTALLLCGASLAFLTYTGRAFSPLGH-FAICLEIVL 193
            |.|.||.....|    .|.::..|.:  |:|..:|.         .|..:..||. ....|..:.
  Rat   221 VVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILA---------AGLGYGLLGDGIGYVLFTLF 276

  Fly   194 LIYTALPMPL-W---LGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPS 254
            ..|:.||:|| |   .|..|::     .::...::|...|:..                     .
  Rat   277 ATYSMLPLPLTWAILAGLGTSL-----LQVTLQVLIPRLAVFS---------------------I 315

  Fly   255 NRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKV 319
            |::| .:::..:.::..|:.:..::....|..|::..:.:..|.:||.|.|.:|:::.||:|..|
  Rat   316 NQVL-AQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFV 379

  Fly   320 ADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTK 384
            ...::|:                 |.......::..|...::|..|||||||||:.|||.:|:|.
  Rat   380 VLEMIND-----------------MTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTL 427

  Fly   385 TAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRC 449
            :|::||.:||:||.|||.|.....|.:|..||||||||||.||||.|||.|||||||.||..:|.
  Rat   428 SAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRF 492

  Fly   450 FDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLG 514
            ..::....|.||:|:|:|:||||::|.|:.:|||||.||.:|||:||.|.|.::|||:.|...|.
  Rat   493 VRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLS 557

  Fly   515 DAYYLEEGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAV 579
            ..|.:|||                                          ||...::..      
  Rat   558 GDYNVEEG------------------------------------------HGKERNEFL------ 574

  Fly   580 QPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVV 644
                                                      |..::|..:|             
  Rat   575 ------------------------------------------RKHNIETYLI------------- 584

  Fly   645 RERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRS 709
                                :||..|...||                           ||:...|
  Rat   585 --------------------KQPEESLLSLP---------------------------EDIVKES 602

  Fly   710 -SCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNH 773
             ||....::|....|     .....||...|.:..:.|||.:.....|       .||     ||
  Rat   603 VSCSDRRNSGATFTE-----GSWSPELPFDNIVGKQNTLAALTRNSIN-------LLP-----NH 650

  Fly   774 RTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRS 838
            ..|.|.:.:....::.....|                                ||:||.....|.
  Rat   651 LAQALHVQSGPEEINKRIEHT--------------------------------IDLRSGDKLRRE 683

  Fly   839 DISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPT 903
            .|.||                                                            
  Rat   684 HIKPF------------------------------------------------------------ 688

  Fly   904 PNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIY 968
              ||                       :|     :.||:....:..:|...|||...:.|.....
  Rat   689 --SL-----------------------MF-----KDSSLEHKYSQMRDEVFKSNLVCAFIVLLFI 723

  Fly   969 ALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLR 1033
            ...|:.:...|:                     :|:.:|....:::                   
  Rat   724 TAIQSLLPSSRL---------------------MPMTIQFSILIML------------------- 748

  Fly  1034 KQSDLQLIRCVRDNARSQRSYLVKP-PLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLAT 1097
             .|.|.||....|       |...| .|||...:.....|.|:                      
  Rat   749 -HSALVLITTAED-------YKCLPLILRKTCCWINETYLARN---------------------- 783

  Fly  1098 PRYNTYIDIFVGIAV-YLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVF-ALFLFTRQMCRR 1160
                  :.||..|.: :|...:::.....:...|...|.....:.||.|..: ..|:||      
  Rat   784 ------VIIFASILINFLGAVINILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFT------ 836

  Fly  1161 QSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVL 1225
                                          |.....:||  :|..::|         ||....:|
  Rat   837 ------------------------------GVLAMVTCA--VFLRLNS---------VLKLAVLL 860

  Fly  1226 LIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVY 1290
            ::||.:.||.       |..|..|       |.::..||                          
  Rat   861 IMIAIYALLT-------ETIYAGL-------FLSYDNLN-------------------------- 885

  Fly  1291 SHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQD 1355
             |:..|....:|||                .|.:.:.|:.|::..::.|...||.|.....|.::
  Rat   886 -HSGEDFLGTKEAS----------------LLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEE 933

  Fly  1356 KVRVQNMKNQADMLLHNIIPKHVAEHL-----KNTAKYSENHHNIAIIFASIVNFNEMYDESYLG 1415
            ...:::::...:.:|.||:|.|||.|.     .|...||:::..:.::||||..|.:.|.::.:.
  Rat   934 INEMKDLREHNENMLRNILPGHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMN 998

  Fly  1416 --GKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGDE--HIHTLMEF 1476
              |.|.||:|||:|.||||||....|:.:|||||||||:||.|||.|..:...|:  |:..|.:|
  Rat   999 NQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADF 1063

  Fly  1477 SIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRI 1541
            |:|:.|.:...||.... |..||||::.|.|.|||||..|..|||||..||:||||||||:..||
  Rat  1064 SLALTESIQEINKHSFN-NFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRI 1127

  Fly  1542 QVGKDCLPFLTNR-YEFEPRGSVYVKGKDHME-----VFLYTTRRDNPLDDDEADKVEQLGTKKM 1600
            ||.::....|.:: :.|:.||.:||||....|     .||....:.||.         .|..:::
  Rat  1128 QVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPF---------ILPPRRL 1183

  Fly  1601 EHEGRDEDVVQGEQQAEDKDEEEEEEEEDDD-----LHSSETTTLFKS--QESLQANG 1651
            ..:.....||.|..|:.::..:::...|:.:     .|.:..|.|..|  :...||.|
  Rat  1184 PGQYSLAAVVLGLVQSLNRQRQKQLLNENSNSGIIKSHYNRRTLLTPSGPEPGAQAEG 1241

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac13ENP_001259575.1 CYCc 302..518 CDD:214485 96/215 (45%)
PHA03307 836..>1015 CDD:223039 18/178 (10%)
Guanylate_cyc 1388..1575 CDD:425528 88/196 (45%)
Adcy8NP_058838.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269|PubMed:16258073, ECO:0000269|PubMed:22494970, ECO:0000269|PubMed:22976297 1..179
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269|PubMed:22976297 1..106
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 38..40
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..117
AcyC 211..564 CDD:441717 129/395 (33%)
Guanylate_cyc 402..586 CDD:425528 95/306 (31%)
Adcy_cons_dom 614..709 CDD:461877 29/233 (12%)
Guanylate_cyc 970..1169 CDD:425528 90/199 (45%)
Involved in CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 1106..1248 44/145 (30%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269|PubMed:19305019 1197..1212 1/14 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1220..1248 7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

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