DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac13E and Adcy8

DIOPT Version :9

Sequence 1:NP_001259575.1 Gene:Ac13E / 32485 FlyBaseID:FBgn0022710 Length:1703 Species:Drosophila melanogaster
Sequence 2:NP_058838.1 Gene:Adcy8 / 29241 RGDID:2036 Length:1248 Species:Rattus norvegicus


Alignment Length:1553 Identity:354/1553 - (22%)
Similarity:546/1553 - (35%) Gaps:569/1553 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   136 VTIMALCFTHWD----LYREHRTVTS--AVTALLLCGASLAFLTYTGRAFSPLGH-FAICLEIVL 193
            |.|.||.....|    .|.::..|.:  |:|..:|.         .|..:..||. ....|..:.
  Rat   221 VVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILA---------AGLGYGLLGDGIGYVLFTLF 276

  Fly   194 LIYTALPMPL-W---LGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPS 254
            ..|:.||:|| |   .|..|::     .::...::|...|:..                     .
  Rat   277 ATYSMLPLPLTWAILAGLGTSL-----LQVTLQVLIPRLAVFS---------------------I 315

  Fly   255 NRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKV 319
            |::| .:::..:.::..|:.:..::....|..|::..:.:..|.:||.|.|.:|:::.||:|..|
  Rat   316 NQVL-AQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFV 379

  Fly   320 ADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTK 384
            ...::|:                 |.......::..|...::|..|||||||||:.|||.:|:|.
  Rat   380 VLEMIND-----------------MTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTL 427

  Fly   385 TAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRC 449
            :|::||.:||:||.|||.|.....|.:|..||||||||||.||||.|||.|||||||.||..:|.
  Rat   428 SAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRF 492

  Fly   450 FDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLG 514
            ..::....|.||:|:|:|:||||::|.|:.:|||||.||.:|||:||.|.|.::|||:.|...|.
  Rat   493 VRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLS 557

  Fly   515 DAYYLEEGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAV 579
            ..|.:|||                                          ||...::..      
  Rat   558 GDYNVEEG------------------------------------------HGKERNEFL------ 574

  Fly   580 QPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVV 644
                                                      |..::|..:|             
  Rat   575 ------------------------------------------RKHNIETYLI------------- 584

  Fly   645 RERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRS 709
                                :||..|...||                           ||:...|
  Rat   585 --------------------KQPEESLLSLP---------------------------EDIVKES 602

  Fly   710 -SCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNH 773
             ||....::|....|     .....||...|.:..:.|||.:.....|       .||     ||
  Rat   603 VSCSDRRNSGATFTE-----GSWSPELPFDNIVGKQNTLAALTRNSIN-------LLP-----NH 650

  Fly   774 RTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRS 838
            ..|.|.:.:....::.....|                                ||:||.....|.
  Rat   651 LAQALHVQSGPEEINKRIEHT--------------------------------IDLRSGDKLRRE 683

  Fly   839 DISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPT 903
            .|.||                                                            
  Rat   684 HIKPF------------------------------------------------------------ 688

  Fly   904 PNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIY 968
              ||                       :|     :.||:....:..:|...|||...:.|.....
  Rat   689 --SL-----------------------MF-----KDSSLEHKYSQMRDEVFKSNLVCAFIVLLFI 723

  Fly   969 ALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLR 1033
            ...|:.:...|:                     :|:.:|....:::                   
  Rat   724 TAIQSLLPSSRL---------------------MPMTIQFSILIML------------------- 748

  Fly  1034 KQSDLQLIRCVRDNARSQRSYLVKP-PLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLAT 1097
             .|.|.||....|       |...| .|||...:.....|.|:                      
  Rat   749 -HSALVLITTAED-------YKCLPLILRKTCCWINETYLARN---------------------- 783

  Fly  1098 PRYNTYIDIFVGIAV-YLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVF-ALFLFTRQMCRR 1160
                  :.||..|.: :|...:::.....:...|...|.....:.||.|..: ..|:||      
  Rat   784 ------VIIFASILINFLGAVINILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFT------ 836

  Fly  1161 QSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVL 1225
                                          |.....:||  :|..::|         ||....:|
  Rat   837 ------------------------------GVLAMVTCA--VFLRLNS---------VLKLAVLL 860

  Fly  1226 LIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVY 1290
            ::||.:.||.       |..|..|       |.::..||                          
  Rat   861 IMIAIYALLT-------ETIYAGL-------FLSYDNLN-------------------------- 885

  Fly  1291 SHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQD 1355
             |:..|....:|||                .|.:.:.|:.|::..::.|...||.|.....|.::
  Rat   886 -HSGEDFLGTKEAS----------------LLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEE 933

  Fly  1356 KVRVQNMKNQADMLLHNIIPKHVAEHL-----KNTAKYSENHHNIAIIFASIVNFNEMYDESYLG 1415
            ...:::::...:.:|.||:|.|||.|.     .|...||:::..:.::||||..|.:.|.::.:.
  Rat   934 INEMKDLREHNENMLRNILPGHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMN 998

  Fly  1416 --GKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGDE--HIHTLMEF 1476
              |.|.||:|||:|.||||||....|:.:|||||||||:||.|||.|..:...|:  |:..|.:|
  Rat   999 NQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADF 1063

  Fly  1477 SIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRI 1541
            |:|:.|.:...||.... |..||||::.|.|.|||||..|..|||||..||:||||||||:..||
  Rat  1064 SLALTESIQEINKHSFN-NFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRI 1127

  Fly  1542 QVGKDCLPFLTNR-YEFEPRGSVYVKGKDHME-----VFLYTTRRDNPLDDDEADKVEQLGTKKM 1600
            ||.::....|.:: :.|:.||.:||||....|     .||....:.||.         .|..:::
  Rat  1128 QVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPF---------ILPPRRL 1183

  Fly  1601 EHEGRDEDVVQGEQQAEDKDEEEEEEEEDDD-----LHSSETTTLFKS--QESLQANG 1651
            ..:.....||.|..|:.::..:::...|:.:     .|.:..|.|..|  :...||.|
  Rat  1184 PGQYSLAAVVLGLVQSLNRQRQKQLLNENSNSGIIKSHYNRRTLLTPSGPEPGAQAEG 1241

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac13ENP_001259575.1 CYCc 302..518 CDD:214485 96/215 (45%)
Guanylate_cyc 361..535 CDD:278633 90/173 (52%)
CYCc 1362..1556 CDD:214485 89/203 (44%)
Guanylate_cyc 1388..1575 CDD:278633 88/196 (45%)
Adcy8NP_058838.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269|PubMed:16258073, ECO:0000269|PubMed:22494970, ECO:0000269|PubMed:22976297 1..179
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269|PubMed:22976297 1..106
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 38..40
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..117
AC_N <158..397 CDD:292831 41/228 (18%)
CYCc 363..561 CDD:214485 96/214 (45%)
Guanylate_cyc 402..586 CDD:278633 95/306 (31%)
DUF1053 614..708 CDD:283888 29/232 (13%)
CYCc 941..1145 CDD:214485 89/204 (44%)
Guanylate_cyc 970..1169 CDD:278633 90/199 (45%)
Involved in CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 1106..1248 44/145 (30%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269|PubMed:19305019 1197..1212 1/14 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1220..1248 7/22 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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