Protein Alignment Ac13E and Gucy2c

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_037302.1
• Gene: Gucy2c / 25711
• RGDID: 2771
• Length: 1072
• Species: Rattus norvegicus
• Alignment Length: 1138
• Identity: 233/1138 - (20%)
• Similarity: 383/1138 - (33%)
• Gaps: 313/1138 - (27%)

  Fly   703 EDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLA----FMDNQMQN------- 756
            :.|.::|....||:...||..||..|:::...:    .:.|..|.:    ::|.::..
  Rat    85 DGLIHKSGDCRSSTCEGLDLLREITRDRKMGCV----LMGPSCTYSTFQMYLDTELNYPMISAGS 145

  Fly   757 -GNGCGYQQLPVLVESNHRTQTLDIPAARPVLH---------HAATSTALASS------------ 799
             |..|.|::          |.|..:|.||.:::         :|...|...:|
  Rat   146 FGLSCDYKE----------TLTRILPPARKLMYFLVDFWKVNNAPFKTFSWNSSYVYKNGSEPED 200

  Fly   800 ---VLRSPEAGVSGGGGCCSPGQYSMYDDII---DVRSYISQSRSDISPFGRSGSYRSQCGRQST 858
               .|.:.||||            |.:.:::   ||.....|.:..:....|..:....||...|
  Rat   201 CFWYLNALEAGV------------SYFSEVLSFKDVLRRSEQFQEILMGRNRKSNVIVMCGTPET 253

  Fly   859 -----GGVNGAGPAGV-----------GAEGRAGTSQ------TAPPVE-------QSPLPRPRA 894
                 |.:..|....|           ..:.||....      |.||.:       ....|..|:
  Rat   254 FYNVKGDLKVADDTVVILVDLFSNHYFEDDTRAPEYMDNVLVLTLPPEKFIANASVSGRFPSERS 318

  Fly   895 --------STLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKD 951
                    .||..|......||.|.|.|:|....|..|....|...|.|             ..|
  Rat   319 DFSLAYLEGTLLFGHMLQTFLENGESVTTPKFARAFRNLTFQGLEGPVT-------------LDD 370

  Fly   952 SGIKSNSRRSSIQQQIYALNQT-------AISQHR-------VSGYFTSSTSSISNLGEVQGLGL 1002
            ||...|     |...:|....|       |...|:       .|..|......:.|  :|.|||
  Rat   371 SGDIDN-----IMCLLYVSLDTRKYKVLMAYDTHKNQTIPVATSPNFIWKNHRLPN--DVPGLG- 427

  Fly  1003 PLAVQPPPPLLMPA---CSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFS 1064
                   |.:||.|   .:..:...|...|..|||..        ||:...|:.:...|....|.
  Rat   428 -------PQILMIAVFTLTGIVVVLLLIALLVLRKYR--------RDHELRQKKWSHIPSENIFP 477

  Fly  1065 L----------------------------YFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYN 1101
            |                            |.|.:.:.:|.:.....|..:.:.|....|.:..||
  Rat   478 LETNETNHVSLKIDDDRRRDTIQRVRQCKYDKKKVILKDLKHCDGNFSEKQKIELNKLLQSDYYN 542

  Fly  1102 -------TYID--IFVGIAVYLCISVSLFLMTQNTVS---PSFRLWVTLFSCFTGIQVFALFLFT 1154
                   ..:|  || |:..| |...||..:..:|:|   .:|..|....|....|.....:|.:
  Rat   543 LTKFYGTVKLDTRIF-GVVEY-CERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHS 605

  Fly  1155 RQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCA--DRIFEAISSWYPWHICLA 1217
                     |.:....|.|||                     :|.  .|:...|:.:.    |.:
  Rat   606 ---------SKIEVHGRLKST---------------------NCVVDSRMVVKITDFG----CNS 636

  Fly  1218 VLMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAF--------- 1273
            :|.....|......|.......:...|.:..:....|:....|..|:|..:|...|
  Rat   637 ILPPKKDLWTAPEHLRQATISQKGDVYSFSIIAQEIILRKETFYTLSCRDQNEKIFRVENSYGTK 701

  Fly  1274 -LAALCFIGIA-VSQLMVYSHNRSDQQQDQEASNFIQEIK--------WFQDYHVEIYLDLLLIL 1328
             .....|:..| ..:|.||...:|..::|.|.....::|:        .|.|...|.|:|.|:..
  Rat   702 PFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRR 766

  Fly  1329 VLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTAKYS-ENH 1392
            :.::..|.|..:..|...|   .|.:|:         ||.|...::|:.|.:.||...... |.:
  Rat   767 LQLYSRNLEHLVEERTQLY---KAERDR---------ADHLNFMLLPRLVVKSLKEKGIVEPELY 819

  Fly  1393 HNIAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASG 1457
            ..:.|.|:.||.|..:.  .|....|.:.:||::...||:::...:   |.|::|||..::.|||
  Rat   820 EEVTIYFSDIVGFTTIC--KYSTPMEVVDMLNDIYKSFDQIVDHHD---VYKVETIGDAYVVASG 879

  Fly  1458 LDPSHRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLE-FNLILRIGMNIGDVTAGVIGTSKLYYDI 1521
            |...:   |:.|...:.:.::.:...:..|..:.|. ..:.:|||::.|...|||:|.....|.:
  Rat   880 LPMRN---GNRHAVDISKMALDILSFMGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCL 941

  Fly  1522 WGDAVNVASRMDSTGLPNRIQVGKDCLPFLTN---RYEFEPRGSVYVKGKDHMEVFLYTTRRDNP 1583
            :||.||.||||:|||||.||.:....:..|..   ::.:|.||..|:||:.....:..|
  Rat   942 FGDTVNTASRMESTGLPLRIHMSSSTIAILRRTDCQFLYEVRGETYLKGRGTETTYWLT------ 1000

  Fly  1584 LDDDEADKVEQLGTKKMEHEGRDEDVVQGEQQAEDKDEEEEEEEEDDDLHSSETTTLFKSQESLQ 1648
                        |.|..|:.......|:.:|:                |.:..:..:..:.:..|
  Rat  1001 ------------GMKDQEYNLPTPPTVENQQR----------------LQTEFSDMIVSALQKRQ 1037

  Fly  1649 ANGGSHLAPNAAATSHTHTITL--TNNNNHNSS 1679
            |:|.....|...|:.....:..  .||::|:|:
  Rat  1038 ASGVKSRRPTRVASYKKGFLEYMQLNNSDHDST 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485
		Guanylate_cyc	361..535	CDD:278633
		CYCc	1362..1556	CDD:214485	57/198 (29%)
		Guanylate_cyc	1388..1575	CDD:278633	56/191 (29%)
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141	71/372 (19%)
		PKc_like	479..749	CDD:304357	51/305 (17%)
		STYKc	501..744	CDD:214568	51/278 (18%)
		CYCc	787..978	CDD:214485	59/207 (29%)
		Guanylate_cyc	814..1001	CDD:278633	57/212 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810