DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_620611.2	Gene:	Gucy2g / 245708	RGDID:	621853	Length:	1103	Species:	Rattus norvegicus

Alignment Length:	272	Identity:	80/272 - (29%)
Similarity:	133/272 - (48%)	Gaps:	54/272 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 QLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHS 363
            ||..||:..||::.:::|..|.:.|:         ||                 ||: .|.|
  Rat   865 QLVAEKRKVEKLLSTMLPSFVGEQLI---------AG-----------------KSV-EPEH--- 899

  Fly   364 MENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCP-E 427
            .|:|:|.|:||||||::.|..:..|:|::||||:..||.........|:.|:||.|...||.| .
  Rat   900 FESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQTHDVYKVETIGDAYMVASGLPIR 964

  Fly   428 PRADHAICCVEMGLGMIDAMRCFDA--QRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSL 490
            ..|.||.....|.|.::.....|..  ...|.:|:|:|:|||.|:.|:||....::.::.:.|::
  Rat   965 NGAQHADEIATMSLHLLSVTTNFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNM 1029

  Fly   491 ANKMESSGKPEQVHISQETSSFL--GDAYYLE---------EGEEVFGHRTYFVVGR------RR 538
            |::||||..|.::|:||.|:..|  ...|:|:         :||:.    |:::.|:      ..
  Rat  1030 ASRMESSSLPLRIHVSQSTARALLVAGGYHLQKRGTISVKGKGEQT----TFWLTGKDGFAVPLP 1090

  Fly   539 DFTRTNSLSPSM 550
            :||...:..|.:
  Rat  1091 EFTEEEAKVPEI 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	69/220 (31%)
		Guanylate_cyc	361..535	CDD:278633	61/187 (33%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
Gucy2g	NP_620611.2	PBP1_GC_G_like	50..439	CDD:107367
		ANF_receptor	66..417	CDD:279440
		PK_GC	558..832	CDD:270894
		CYCc	868..1058	CDD:214485	69/219 (32%)
		Guanylate_cyc	895..1081	CDD:278633	63/193 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900