DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001116066.2	Gene:	Phlpp2 / 244650	MGIID:	2444928	Length:	1355	Species:	Mus musculus

Alignment Length:	504	Identity:	96/504 - (19%)
Similarity:	158/504 - (31%)	Gaps:	149/504 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   670 SPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEE 734
            |..||....|..|:..|...|.|..:        .:.....|.|.... .|.|....|.:.|:.:
Mouse   905 SSALLCYIRPDTADPTSSFSLTVANV--------GMCQAVLCRGGKPV-PLSKVFSLEHDPEEAQ 960

  Fly   735 LHQHNQLNPEETLAFMDNQMQNG-------NGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAA- 791
                 ::..::.:...||:: ||       .||.|....:|.:.:..:..|.|.....:|.:.|
Mouse   961 -----RVKDQKAIITEDNKV-NGVTCCTRLLGCTYLYPWILPKPHIASTPLTIQDELLILGNKAL 1019

  Fly   792 ---TSTALASSVLRSPEAGVSGGGGCCSPGQ-YSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQ 852
               .|...|.:.:|..:..::.....|:..| |...|::..:..|::        .|..|.....
Mouse  1020 WEHLSYLEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLN--------IGEEGCTCEM 1076

  Fly   853 CGRQSTGGVNGAGPA---------------GVGAE--GRAGTSQTAPPV-------------EQS 887
            .|....|.|..|..|               |:.:|  ....||:.:..|             |.|
Mouse  1077 NGLTLPGPVGFASTAALKDTPKPTTPSSSSGIASEFSSEMSTSEVSSEVGSTASDEHNTVGLEAS 1141

  Fly   888 PLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDS 952
            .||||....         ||.|..|:                |:|    .||.|....::::.|:
Mouse  1142 LLPRPERRC---------SLHPASSA----------------GVF----QRQPSCATFSSNQSDN 1177

  Fly   953 GIKS-----------NSRRSSIQQQIYAL--------------NQTAISQHRVSGYFTSSTSSIS 992
            |:.|           |..|..::..|:..              :..|.|:.|..|
Mouse  1178 GLDSDDDQPVEGVITNGSRVEVEVDIHCCRGREPESSPPLPKNSSNACSEERARG---------- 1232

  Fly   993 NLGEVQGLGLPLAVQPPPPLLMPACSSQM---ADPLAACL--QQLRK------QSDLQLIRCVRD 1046
                 .|.|:.........:|:||...:|   ..|..:||  ::|..      :..|.||....:
Mouse  1233 -----AGFGIRRQNSVNSGILLPANRDKMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATE 1292

  Fly  1047 NARSQRSYLVKP-PLRKFSLYFKSRQLERDFRS--KAHRFG-AENETEG 1091
            ..:.:..|...| .|.....:...|.||.:.:.  |.|:.| .|.|..|
Mouse  1293 APKRKTGYFAAPTQLEPEDQFVVPRDLEEEVKEQMKQHQEGRPEPEPRG 1341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485
		Guanylate_cyc	361..535	CDD:278633
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
Phlpp2	NP_001116066.2	PH_PHLPP-like	181..275	CDD:270131
		leucine-rich repeat	285..305	CDD:275380
		leucine-rich repeat	306..332	CDD:275380
		LRR_RI	309..548	CDD:238064
		LRR_8	354..412	CDD:290566
		leucine-rich repeat	356..378	CDD:275380
		leucine-rich repeat	379..401	CDD:275380
		leucine-rich repeat	402..424	CDD:275380
		LRR_8	425..483	CDD:290566
		leucine-rich repeat	425..448	CDD:275380
		LRR_RI	447..714	CDD:238064
		leucine-rich repeat	449..472	CDD:275380
		leucine-rich repeat	474..493	CDD:275380
		leucine-rich repeat	494..513	CDD:275380
		leucine-rich repeat	514..535	CDD:275380
		LRR_8	536..592	CDD:290566
		leucine-rich repeat	536..558	CDD:275380
		leucine-rich repeat	559..581	CDD:275380
		leucine-rich repeat	582..597	CDD:275380
		LRR_8	604..664	CDD:290566
		leucine-rich repeat	604..627	CDD:275380
		leucine-rich repeat	628..653	CDD:275380
		leucine-rich repeat	654..677	CDD:275380
		LRR_8	676..735	CDD:290566
		leucine-rich repeat	678..701	CDD:275380
		leucine-rich repeat	702..724	CDD:275380
		leucine-rich repeat	747..768	CDD:275380
		PP2Cc	816..1065	CDD:238083	33/174 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900