DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001028494.1	Gene:	Gucy1a2 / 234889	MGIID:	2660877	Length:	730	Species:	Mus musculus

Alignment Length:	440	Identity:	110/440 - (25%)
Similarity:	176/440 - (40%)	Gaps:	102/440 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 IVLLIYTALPMPLWLGASTAISYSIAFEMVSHMV----------IGCSAIHGGPMHGGGGAAGGS 245
            :||.:...|...|......|:.:...||:||.|:          :....:........|......
Mouse   336 VVLQLGEGLRKQLRYDTHRALKFEDCFEIVSPMINATFDRVLLRLSTPFVIRTKPEASGTENEDK 400

  Fly   246 GMEANGD-----PSNRILIL---------RIMA---HLS---VH-------LVGVHV-----LIM 278
            .||..|.     .|:.||.|         .:|.   |||   :|       |||...     |..
Mouse   401 VMEIKGQMIHVPESSAILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKK 465

  Fly   279 NLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHY 343
            .:.:::.|..:..|      .||.||:....:::|:.|..||..|.               :...
Mouse   466 RMDKLKATLERTHQ------ALEEEKKKTVDLLYSIFPGDVAQQLW---------------QGQQ 509

  Fly   344 MRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSG 408
            ::.|..:|               |::||:||||||.:.:..|..|::.:||:|:.|||..|.|..
Mouse   510 VQARKFDD---------------VTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGLLD 559

  Fly   409 CEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGI 473
            ..|:.|:||.|...||.......||.....|.|.|::..........:.::||:|:|:|:||.|:
Mouse   560 IYKVETIGDAYCVASGLHRKSLCHAKPIALMALKMMELSEEVLTPDGKAIQMRIGIHSGSVLAGV 624

  Fly   474 VGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRR 538
            ||.|..::.::.|:|:||:|.||...|.::::|..|       |.|.:.|:.|   |:  :.|.|
Mouse   625 VGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTT-------YQLLKREDSF---TF--IPRSR 677

  Fly   539 DFTRTNSLSPSMPANATGSSLLL-----PGAHGASLSQSATNVSAVQPNV 583
            :     .|..:.|....|....|     |.....|||.|  .:..|..|:
Mouse   678 E-----ELPDNFPKEIPGVCYFLELRTDPKPPKPSLSSS--RIKKVSYNI 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	61/215 (28%)
		Guanylate_cyc	361..535	CDD:278633	57/173 (33%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
Gucy1a2	NP_001028494.1	HNOB	<157..268	CDD:285002
		HNOBA	314..501	CDD:285003	35/170 (21%)
		CYCc	483..672	CDD:214485	65/228 (29%)
		Guanylate_cyc	512..696	CDD:278633	64/215 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810