DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and PHLPP2

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_055835.2	Gene:	PHLPP2 / 23035	HGNCID:	29149	Length:	1323	Species:	Homo sapiens

Alignment Length:	516	Identity:	99/516 - (19%)
Similarity:	157/516 - (30%)	Gaps:	155/516 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   670 SPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSC------GGSSSAGHLDKERERER 728
            |..||....|..|:..|...|.|             .|..:|      ||....  |.|....|:
Human   873 SSALLCYIRPDTADPASSFSLTV-------------ANVGTCQAVLCRGGKPVP--LSKVFSLEQ 922

  Fly   729 EKEKEELHQHNQLNPEETLAFMDNQMQNG-------NGCGY-----------QQLPVLVES---- 771
            :.|:.:     ::..::.:...||:: ||       .||.|           ...|:.::.
Human   923 DPEEAQ-----RVKDQKAIITEDNKV-NGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQDELLI 981

  Fly   772 -------NHRTQTLDIPAARPV---LHHAATSTALASSVLRSPEAGVS------GGGGC-CS--- 816
                   .|.:.|..:.|.|.|   |..|.....||.|.......|..      |..|| |.
Human   982 LGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMNG 1046

  Fly   817 ---PGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTS 878
               ||......     .:.|..:....:|...||.........||..|:....:....|..||..
Human  1047 LTLPGPVGFAS-----TTTIKDAPKPATPSSSSGIASEFSSEMSTSEVSSEVGSTASDEHNAGGL 1106

  Fly   879 QTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSIC 943
            .||      .||||....         ||.|.|:|                |:|    .||.|..
Human  1107 DTA------LLPRPERRC---------SLHPTPTS----------------GLF----QRQPSSA 1136

  Fly   944 PSATSRKDSGIKS-----------NSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEV 997
            ..::::.|:|:.|           |..:..::..|:......:..   |.....|:.::.:....
Human  1137 TFSSNQSDNGLDSDDDQPVEGVITNGSKVEVEVDIHCCRGRDLEN---SPPLIESSPTLCSEEHA 1198

  Fly   998 QG--LGLPLAVQPPPPLLMPACSSQM---ADPLAACL--QQLRK------QSDLQLIRCVRDNAR 1049
            :|  .|:.........:|:|....:|   ..|..:||  ::|..      :..|.||....:..:
Human  1199 RGSCFGIRRQNSVNSGMLLPMSKDRMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEVPK 1263

  Fly  1050 SQRSYLVKP----PLRKFSLYFKSRQLERDFRS--KAHRFG-------AENETEGPPTLAT 1097
            .:..|...|    |..:|.:   ...||.:.:.  |.|:..       .|:.||.|....|
Human  1264 RKTGYFAAPTQMEPEDQFVV---PHDLEEEVKEQMKQHQDSRLEPEPHEEDRTEPPEEFDT 1321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485
		Guanylate_cyc	361..535	CDD:278633
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
PHLPP2	NP_055835.2	PH_PHLPP-like	149..243	CDD:270131
		LRR 1	250..271
		leucine-rich repeat	253..273	CDD:275380
		LRR 2	273..296
		leucine-rich repeat	274..300	CDD:275380
		LRR 3	300..321
		leucine-rich repeat	301..323	CDD:275380
		LRR_RI	313..606	CDD:238064
		LRR_8	322..380	CDD:290566
		LRR 4	323..344
		leucine-rich repeat	324..346	CDD:275380
		LRR 5	346..368
		leucine-rich repeat	347..369	CDD:275380
		LRR 6	369..390
		leucine-rich repeat	370..416	CDD:275380
		LRR 7	392..412
		LRR 8	416..439
		leucine-rich repeat	418..440	CDD:275380
		LRR 9	440..460
		leucine-rich repeat	442..461	CDD:275380
		LRR 10	461..480
		leucine-rich repeat	462..481	CDD:275380
		LRR 11	481..502
		leucine-rich repeat	482..503	CDD:275380
		LRR 12	503..524
		leucine-rich repeat	504..526	CDD:275380
		LRR 13	526..547
		leucine-rich repeat	527..549	CDD:275380
		LRR_8	549..606	CDD:290566
		LRR 14	549..570
		leucine-rich repeat	550..565	CDD:275380
		LRR 15	571..592
		leucine-rich repeat	572..595	CDD:275380
		LRR 16	595..616
		leucine-rich repeat	596..645	CDD:275380
		LRR 17	621..644
		LRR_8	645..703	CDD:290566
		LRR_4	645..685	CDD:289563
		LRR 18	645..666
		leucine-rich repeat	646..669	CDD:275380
		LRR 19	669..690
		leucine-rich repeat	670..692	CDD:275380
		LRR 20	692..713
		leucine-rich repeat	693..714	CDD:275380
		LRR 21	714..735
		leucine-rich repeat	715..734	CDD:275380
		LRR 22	737..758
		leucine-rich repeat	738..764	CDD:275380
		PP2Cc	784..1033	CDD:238083	35/180 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1157		29/131 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1285..1323		9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900