DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and Adcy5

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001012783.3	Gene:	Adcy5 / 224129	MGIID:	99673	Length:	1262	Species:	Mus musculus

Alignment Length:	1664	Identity:	373/1664 - (22%)
Similarity:	571/1664 - (34%)	Gaps:	661/1664 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSESRRQSVSSRAMPPGV-LVNDSRANSTDDIQIALAPHIQTYLSQTGRRHSCCSVMLPVAFERA 64
            :.|.|.:..::..:.||. :|.|...:......:|........||    ..:||..:|.:
Mouse   161 LEERRGKGRAAEELEPGTGIVEDGDGSEDGGSSVASGSGTGAVLS----LGACCLALLQI----- 216

  Fly    65 AAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLYFVVDGGSEDFWRPISSS 129
                :...||.|..||..||         ||.|.|:...|..||
Mouse   217 ----FRSKKFPSDKLERLYQ---------RYFFRLNQSSLTMLM--------------------- 247

  Fly   130 FSMLSLVTIMALCF--THWDLYREHRTVTSAVTALL-----LCGASLAFLTYTGRAFSPLGHFAI 187
             ::|.||.::.|.|  ....|...:..|.:|...::     ||..:.....:.|.|...|....:
Mouse   248 -AVLVLVCLVMLAFHAARPPLQIAYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVL 311

  Fly   188 CLEIVLLIYTALPMPLWLGASTAISYSIAF----------EMVSHMVIG--CSAIHGGPMHGGGG 240
            .:::|.|:   ||.|  ..||..|.:::.|          .|.:.::.|  .||:|
Mouse   312 AVQVVGLL---LPQP--RSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALH--------- 362

  Fly   241 AAGGSGMEANGDPSNRILILRIMAHLSV----HLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLE 301
                ..:..:.:..::.|:.::::::.:    ::|||.......|..|..|.:..:.:..|...:
Mouse   363 ----LAISLHTNSQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQ 423

  Fly   302 MEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKS---LFRPFHMHS 363
            .|.|.:|:::.||:|..||                       |..:|..:.|.   :|...::..
Mouse   424 RENQQQERLLLSVLPRHVA-----------------------MEMKADINAKQEDMMFHKIYIQK 465

  Fly   364 MENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEP 428
            .:|||||||||.|||.::|..||::||..||:||.|||.|.:.:.|.:|..||||||||||.||.
Mouse   466 HDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEA 530

  Fly   429 RADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANK 493
            |||||.||||||:.||:|:..........|.||||:|:|.|.||::|.|:.:||||||||:|||.
Mouse   531 RADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANH 595

  Fly   494 MESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSS 558
            ||:.||..::||::.|.::|...|.:|
Mouse   596 MEAGGKAGRIHITKATLNYLNGDYEVE-------------------------------------- 622

  Fly   559 LLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRD 623
               ||..|                                                        |
Mouse   623 ---PGCGG--------------------------------------------------------D 628

  Fly   624 RDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKI 688
            |:.
Mouse   629 RNA-------------------------------------------------------------- 631

  Fly   689 KLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQ 753
            .||...|..||        ..||                .:|.|||.....::|
Mouse   632 YLKEHSIETFL--------ILSC----------------TQKRKEEKAMIAKMN----------- 661

  Fly   754 MQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPG 818

Mouse   662 ----------------------------------------------------------------- 661

  Fly   819 QYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPP 883
                                                ||.|..: |..|...|||
Mouse   662 ------------------------------------RQRTNSI-GHNPPHWGAE----------- 678

  Fly   884 VEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATS 948
                             ||..|.|              .||.|                   :..
Mouse   679 -----------------RPFYNHL--------------GGNQV-------------------SKE 693

  Fly   949 RKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLL 1013
            .|..|.:....::
Mouse   694 MKRMGFEDPKDKN---------------------------------------------------- 706

  Fly  1014 MPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRS 1078
                :.:.|:|.....:.|.:..|.:.|    |..||:.       :|||.|.|:...||:.:..
Mouse   707 ----AQESANPEDEVDEFLGRAIDARSI----DRLRSEH-------VRKFLLTFREPDLEKKYSK 756

  Fly  1079 KA-HRFGA--------------ENETEGPPTLATPRYNTYIDIFVGIA-------VYLCISVSLF 1121
            :. .||||              ...|..|.:|....:  |:..|:.:|       :|.|  |.||
Mouse   757 QVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLSF--YLSCFLLLALVVFVSVIYAC--VKLF 817

  Fly  1122 LMTQNTVSPSF---RLWVTLFSCFTGIQVFALFLFTRQMCRRQS-------GSNVS-NRFRS--- 1172
            .....|:|...   :...||...||...||........||..::       ..|:: |:..:
Mouse   818 PTPLQTLSRKIVRSKKNSTLVGVFTITLVFLSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHV 882

  Fly  1173 -KSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANFLLLDL 1236
             :|..:..| .||:|.....:|:..             :|.:...:||::
Mouse   883 MESAFNYSL-GDEQGFCGSPQPNCN-------------FPEYFTYSVLLS--------------- 918

  Fly  1237 EQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAV-----------SQLMVY 1290
                         :..|.|    |.|::|..:.||  :.|:.||.:.:           :.|:|.
Mouse   919 -------------LLACSV----FLQISCIGKLVL--MLAIEFIYVLIVEVPGVTLFDNADLLVT 964

  Fly  1291 SH-----NRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLN-REFEIGYRLTFYGN 1349
            ::     |....|..:.|:....::         :...::.:.||..:|: ::.|...||.|...
Mouse   965 ANAIDFSNNGTSQCPEHATKVALKV---------VTPIIISVFVLALYLHAQQVESTARLDFLWK 1020

  Fly  1350 AVANQDKVRVQNMKNQADMLLHNIIPKHVAEHL-----KNTAKYSENHHNIAIIFASIVNFNEMY 1409
            ..|.::|..::.::.....|||||:||.||.|.     :|...|.::...:|::||||.||:|.|
Mouse  1021 LQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFY 1085

  Fly  1410 DESYLG--GKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGL-DPSHRGTGDEHIH 1471
            .|....  |.|.||:|||:|.||||::|...||.:|||||||||:|||||| |.::...|..||.
Mouse  1086 VELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGKTHIK 1150

  Fly  1472 TLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTG 1536
            .:.:|::.:.:.:...|:.... |..::||:|||.|.|||||..|..|||||:.|||||||||||
Mouse  1151 AIADFAMKLMDQMKYINEHSFN-NFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTG 1214

  Fly  1537 LPNRIQVGKDCLPFL-TNRYEFEPRGSVYVKGKDHMEVF 1574
            :|:||||..|....| .|.|:.|.||.|.||||..|..:
Mouse  1215 VPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTY 1253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	96/218 (44%)
		Guanylate_cyc	361..535	CDD:278633	86/173 (50%)
		CYCc	1362..1556	CDD:214485	95/202 (47%)
		Guanylate_cyc	1388..1575	CDD:278633	94/191 (49%)
Adcy5	NP_001012783.3	AC_N	1..459	CDD:292831	72/382 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..194		6/32 (19%)
		CYCc	425..620	CDD:214485	96/217 (44%)
		Guanylate_cyc	461..622	CDD:278633	85/160 (53%)
		DUF1053	669..761	CDD:283888	29/219 (13%)
		CYCc	1037..1238	CDD:214485	96/201 (48%)
		Guanylate_cyc	1063..1257	CDD:278633	94/192 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810