DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and gcy-36

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_510557.3	Gene:	gcy-36 / 191657	WormBaseID:	WBGene00001556	Length:	675	Species:	Caenorhabditis elegans

Alignment Length:	287	Identity:	79/287 - (27%)
Similarity:	128/287 - (44%)	Gaps:	56/287 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1352 ANQDKVRVQNM-------KNQADMLLHNIIPKHVAEHLK-NTAKYSENHHNIAIIFASIVNFNEM 1408
            ||.:  :::||       |.:.|.||..::|..||:.|| ..:..:..:....::|..:..|.::
Worm   400 ANNE--QLENMAKDLEVEKGKTDALLREMLPPSVAQQLKQGLSVEAREYEEATVMFTDVPTFQQI 462

  Fly  1409 YDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGDEHIHTL 1473
            .  .....|:.:.:||||...||.|:.   .:...|::|:|.::|:..|:.    ...|:|...:
Worm   463 V--PLCTPKDIVHLLNELFTKFDRLIG---IQKAYKVETVGDSYMSVGGIP----DLVDDHCEVI 518

  Fly  1474 MEFSIAM----QEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDS 1534
            ...::.|    :.|.|......|.    :|.|::.|.|.|||:|.....|.::||.||.:|||:|
Worm   519 CHLALGMVMEARTVCDPITNTPLH----IRAGIHSGPVVAGVVGAKMPRYCLFGDTVNTSSRMES 579

  Fly  1535 TGLPNRI---QVGKDCLPFLTNRYEFEPRGSVYVKGKDHMEVF------------LYTTRRD--- 1581
            .....||   :..|.|.. .|.|:||||||.|.:|||..|..:            :...|||
Worm   580 HSPIGRIHCSENAKKCAE-STGRFEFEPRGRVQIKGKGEMNTYFLLRSFKRSIWEIIDRRRDENC 643

  Fly  1582 NPLD----------DDEADKVEQLGTK 1598
            |.:|          ||..:||.|..:|
Worm   644 NSIDGYNELREGYVDDVLNKVTQKNSK 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485
		Guanylate_cyc	361..535	CDD:278633
		CYCc	1362..1556	CDD:214485	54/208 (26%)
		Guanylate_cyc	1388..1575	CDD:278633	55/205 (27%)
gcy-36	NP_510557.3	HNOB	3..167	CDD:285002
		HNOBA	217..435	CDD:285003	11/36 (31%)
		CYCc	415..604	CDD:214485	53/202 (26%)
		Guanylate_cyc	441..624	CDD:278633	55/196 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810