DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and gcy-25

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001294116.1	Gene:	gcy-25 / 191653	WormBaseID:	WBGene00001549	Length:	1034	Species:	Caenorhabditis elegans

Alignment Length:	374	Identity:	81/374 - (21%)
Similarity:	159/374 - (42%)	Gaps:	66/374 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1280 IGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKWFQDYHVEI------YLDLLLILVLVWF----- 1333
            :.:.:.|::.|....:::|:..:....:...:.....|.::      .:.||.|:...|.
Worm   670 LAMCIYQILFYMRPFAERQESIKELAHLLSSQSTAPLHPKVPEGNSFTMRLLSIIQQCWLYKPAA 734

  Fly  1334 ----------LNREFEIGYRLTFYGNAV-------ANQDKVRVQNMKN-QADM-----LLHNIIP 1375
                      :||||....:.|.....:       ||.:::..:..:. :.||     ||:.::|
Worm   735 RPALIKITDAVNREFGQDVKGTLIDQMIEMIDEYSANLEQIVAERTRELEQDMSVTENLLYQLLP 799

  Fly  1376 KHVAEHLKN-TAKYSENHHNIAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSRPEF 1439
            |.||:.::: .....|.|.::.::...:..|.: :.|::: ....|..|.||...||.::.:
Worm   800 KSVADSIRSGKTVVPEQHSSVTLLVVDVCQFTK-FCEAFI-PVHILETLQELYSSFDNIVQK--- 859

  Fly  1440 RAVEKIKTIGSTFMAASGLDPSHRGTGDEHIHTLMEFSIAMQEVVDAFN-KDLLEFNLILRIGMN 1503
            ....|::.:|..::..||:...   :|..|:..:.:.|:.:|..:..|. :......|.:::|:.
Worm   860 NKAFKVENVGDAYLICSGIPEM---SGFRHLREICKISLKLQAFMKTFKVRHRPSHTLQIKMGIT 921

  Fly  1504 IGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNRYE---FEPRGSVYV 1565
            .|.|.||::|::...:.|:||.||:|.||.|||.|..||:.:.....|..::.   .|.||.:.|
Worm   922 SGAVAAGILGSTAPRFCIFGDTVNMACRMASTGNPGSIQLSELTANTLMEKFPSFMLEERGMIDV 986

  Fly  1566 KGKDHMEVFLYTTRRD--------------NPLDDDEADKVEQLGTKKM 1600
            |||.....|..|..:|              ...:.||||     .:|||
Worm   987 KGKGACLTFWLTGEKDIMRRQSSRSSCISQIKFELDEAD-----NSKKM 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485
		Guanylate_cyc	361..535	CDD:278633
		CYCc	1362..1556	CDD:214485	49/201 (24%)
		Guanylate_cyc	1388..1575	CDD:278633	48/190 (25%)
gcy-25	NP_001294116.1	PBP1_iGluR_N_LIVBP_like	56..>230	CDD:107346
		PKc_like	473..746	CDD:304357	8/75 (11%)
		SPS1	474..>736	CDD:223589	8/65 (12%)
		HNOBA	<764..805	CDD:285003	10/40 (25%)
		CYCc	790..976	CDD:214485	47/193 (24%)
		Nucleotidyl_cyc_III	812..999	CDD:299850	49/194 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810