DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and gcy-23

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_500309.3	Gene:	gcy-23 / 191652	WormBaseID:	WBGene00001548	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	349	Identity:	85/349 - (24%)
Similarity:	154/349 - (44%)	Gaps:	76/349 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 LIYTALPMPLWLGASTAISY----SIAFEMVSH-----------MVIGCSAIHGGPMHGGGGAAG 243
            :::.|||.|.....|..:.|    :..|....|           :::.|
Worm   738 ILFRALPFPNGTNVSEVMDYIRDGTKTFRPTVHDRTQIHPDLVALLLDC---------------- 786

  Fly   244 GSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRR--QLEMEKQL 306
                 .|.:|..|..|.|:..:...:|.....|:..::||...:....:.|:..|  .||.....
Worm   787 -----WNENPEVRPSIRRVRLNTENYLKVKGSLVDQMMRMMEQYANNLEKLVAERTGMLEEANVR 846

  Fly   307 KEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILF 371
            .:|::..::|..||                             |::| :.|.....:.:..:::|
Worm   847 ADKLLGQLLPKYVA-----------------------------NELK-MGRSVPAKTFDMATVMF 881

  Fly   372 ADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRA-DHA-- 433
            :||||||.:.|:.|..::|.:||.::.:|||..:..|..|:.|:||.|..|||.||... :|.
Worm   882 SDIVGFTTICSSSTPLEVVSMLNSIYSKFDDAINKHGSYKVETIGDAYMIVSGIPEENGNEHIRN 946

  Fly   434 ICCVEMGLGMIDAMRCFDAQRHEGVKMRV--GVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMES 496
            ||...:.|.::  ::.::......||:|:  |:|||||..|:||....::.::.:.|::|::|||
Worm   947 ICNTALELMLL--LKTYEIPHRRNVKLRIRLGIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMES 1009

  Fly   497 SGKPEQVHISQETSSFLGDAYYLE 520
            :.:||::.:|||...|. ..||.|
Worm  1010 TSEPEKIQMSQEARDFC-VRYYSE 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	60/220 (27%)
		Guanylate_cyc	361..535	CDD:278633	56/165 (34%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
gcy-23	NP_500309.3	Periplasmic_Binding_Protein_Type_1	38..407	CDD:299141
		ANF_receptor	38..385	CDD:279440
		PK_GC	509..806	CDD:270894	14/88 (16%)
		HNOBA	<817..863	CDD:285003	11/74 (15%)
		CYCc	842..1035	CDD:214485	63/224 (28%)
		Guanylate_cyc	869..1056	CDD:278633	56/167 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900