DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and gcy-21

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001364740.1	Gene:	gcy-21 / 191651	WormBaseID:	WBGene00001546	Length:	1163	Species:	Caenorhabditis elegans

Alignment Length:	309	Identity:	86/309 - (27%)
Similarity:	145/309 - (46%)	Gaps:	53/309 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 DPSNRILILRIMAHLSVHLVGVHVLIM-NLVRMRGTFM-KVGQNLLVR-RQLEMEKQLKEKMIHS 313
            ||.||..:.:|...|....:|:...|| |:|.|...:. |:.:::..| .:||.||...|.::..
Worm   864 DPLNRPSLHQIKRKLKPLTIGLKRTIMDNMVSMIEKYTDKLEKDIAERNEELEGEKAKSEALLKM 928

  Fly   314 VMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFT 378
            ::|..|||.|                       :..::|.:       .|.||.::.|:|..||.
Worm   929 MLPEVVADSL-----------------------KLGSNVSA-------ESFENCTVFFSDCPGFV 963

  Fly   379 RMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRAD-HAICCVEMGLG 442
            .||:|.....:|:.||||:..||.:.......|:.|:.|.|...||.|.|..: ||.....:||.
Worm   964 EMSATSKPIDIVQFLNDLYTVFDRIIDQFDVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLA 1028

  Fly   443 MIDAMRCFDAQRH---EGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVH 504
            ::.|:..|.. ||   |.|::|:|:::|..:.|:||.:..::.::.:.|:.|::|||:|.|.:::
Worm  1029 LLKAVESFKI-RHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRIN 1092

  Fly   505 ISQETSSFLGD--AYYLEE---------GEEVFGHRTYFVVGRRRDFTR 542
            .|......|..  .|.:||         |:::    ||||.|...|..|
Worm  1093 CSGTAKEILDQLGGYEIEERGIVEMKGKGKQM----TYFVRGENSDMRR 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	59/221 (27%)
		Guanylate_cyc	361..535	CDD:278633	58/188 (31%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
gcy-21	NP_001364740.1	Periplasmic_Binding_Protein_type1	58..422	CDD:415822
		PK_GC	612..881	CDD:270894	6/16 (38%)
		HNOBA	<890..938	CDD:400168	15/47 (32%)
		Guanylate_cyc	944..1130	CDD:306677	59/197 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900