DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and gcy-15

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001364713.1	Gene:	gcy-15 / 191648	WormBaseID:	WBGene00001541	Length:	1104	Species:	Caenorhabditis elegans

Alignment Length:	309	Identity:	86/309 - (27%)
Similarity:	145/309 - (46%)	Gaps:	53/309 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 DPSNRILILRIMAHLSVHLVGVHVLIM-NLVRMRGTFM-KVGQNLLVR-RQLEMEKQLKEKMIHS 313
            ||.||..:.:|...|....:|:...|| |:|.|...:. |:.:::..| .:||.||...|.::..
Worm   805 DPLNRPSLHQIKRKLKPLTIGLKRTIMDNMVSMIEKYTDKLEKDIAERNEELEAEKAKSEALLKM 869

  Fly   314 VMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFT 378
            ::|..|||.|                       :..::|.:       .|.||.::.|:|..||.
Worm   870 MLPEVVADSL-----------------------KLGSNVSA-------ESFENCTVFFSDCPGFV 904

  Fly   379 RMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRAD-HAICCVEMGLG 442
            .||:|.....:|:.||||:..||.:.......|:.|:.|.|...||.|.|..: ||.....:||.
Worm   905 EMSATSKPIDIVQFLNDLYTVFDRIIDQFDVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLA 969

  Fly   443 MIDAMRCFDAQRH---EGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVH 504
            ::.|:..|.. ||   |.|::|:|:::|..:.|:||.:..::.::.:.|:.|::|||:|.|.:::
Worm   970 LLKAVESFKI-RHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRIN 1033

  Fly   505 ISQETSSFLGD--AYYLEE---------GEEVFGHRTYFVVGRRRDFTR 542
            .|......|..  .|.:||         |:::    ||||.|...|..|
Worm  1034 CSGTAKEILDQLGGYEIEERGIVEMKGKGKQM----TYFVRGENSDMRR 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	59/221 (27%)
		Guanylate_cyc	361..535	CDD:278633	58/188 (31%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:415822
		PK_GC	553..822	CDD:270894	6/16 (38%)
		HNOBA	<831..879	CDD:400168	15/47 (32%)
		Guanylate_cyc	885..1071	CDD:306677	59/197 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900