Protein Alignment Ac13E and acy-2

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_504553.1
• Gene: acy-2 / 191607
• WormBaseID: WBGene00000069
• Length: 1080
• Species: Caenorhabditis elegans
• Alignment Length: 1613
• Identity: 351/1613 - (21%)
• Similarity: 546/1613 - (33%)
• Gaps: 711/1613 - (44%)

  Fly   123 WRPISSSFSMLSLVTIMALCFTHWDLYREHRTVTSAV--------TALLLCGASLAFLTYTGRAF 179
            |.|.....|:..:..::..||              |:        ..|:|...||..|.   .||
 Worm    78 WSPFCFYASIFFIAYLILTCF--------------AIRIRQPKEGMGLVLVSLSLCVLL---PAF 125

  Fly   180 SPLGHFAICLEIVLLI---------------YTALPMP--------------------LWLGAST 209
            |.:.|    |.:|:.:               ||:|.:.                    .|:.|:.
 Worm   126 SWILH----LPVVIFVSRERIHTNEHDHSALYTSLCIASVIQFFILPRHRRIFFVVAVSWIVANF 186

  Fly   210 AISYSIAFEMVS-HMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGV 273
            .:..:|.::.:: :.:..||.: ...:|.|..|..|...::| :..||..|.|
 Worm   187 LLIVAINWDALNVNTLFMCSCL-SLFLHQGVIALVGVVADSN-EAGNRAEIAR------------ 237

  Fly   274 HVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADML---LNEGGPSGLDAG 335
                           |:.:.:..|.:||..|..:|:::.||:|..:||.:   :.:...:|
 Worm   238 ---------------KLTEAVYRRTELETLKDRQEQLLLSVIPAYLADQVSKSIIQSSSTG---- 283

  Fly   336 GLPPESHYMRPR-ASNDVKS--LFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLF 397
                 |....|| ..|:.|:  ||...|:...:||||||||||.||.:::..||:.||..||:|:
 Worm   284 -----STVEVPRTGKNNTKNHKLFHDLHVQVHDNVSILFADIVNFTVLAAQLTAKDLVRTLNELY 343

  Fly   398 ERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRV 462
            .:||.......|.:|..||||||||||.|..|.:||..||.|||.||:.::.........|.||:
 Worm   344 SKFDRDAQRLQCMRIKFLGDCYYCVSGMPVNRPNHADMCVVMGLEMINTIKQVRIATGVDVNMRI 408

  Fly   463 GVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSS-FLGDAYYLEEGEEVF 526
            |||||:|||||:|.|:.:||:||:||:|||.|||:|.|..|||::.|.. .|||
 Worm   409 GVHTGSVLCGIMGLRKWQFDIWSDDVTLANHMESAGVPGAVHITKSTKDMLLGD----------- 462

  Fly   527 GHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQ 591
                |.:|....|                       ..|..|..|...::      :|..:...:
 Worm   463 ----YCIVDANTD-----------------------DPHVVSYGQPTYHI------LPDKTSAIE 494

  Fly   592 LSSSLNPSPVLSMRPRLTS-LSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTK 655
            .::|:..:..||..|.|.| :|||.:         |.:.:....|          |.|....|.|
 Worm   495 RTASIYRNSRLSTSPALQSRMSMKAK---------VSKMVEFWGA----------ETPFANFTKK 540

  Fly   656 SLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHL 720
            ....|.|                 ||..|.     ::.:.|.::.....:|
 Worm   541 KFSASHD-----------------PALITD-----EIARRPTYINTIPSMT-------------- 569

  Fly   721 DKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARP 785
                          |.::|..|      |..|.:.:...|   :||.            |||:..
 Worm   570 --------------LIENNLTN------FSFNNINSMFNC---ELPT------------IPASPK 599

  Fly   786 VLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYR 850
            :|.                                                     ||.|.
 Worm   600 LLW-----------------------------------------------------PFSRK---- 607

  Fly   851 SQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTS 915
                                       |.|.                               :.|
 Worm   608 ---------------------------SITC-------------------------------NLS 614

  Fly   916 PC------CLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTA 974
            .|      |:|:...::          ...|..||                |.:.||| :|.|
 Worm   615 DCVLLTFVCIPSAFANL----------LLCSLYCP----------------SDVLQQI-SLQQ-- 650

  Fly   975 ISQHRVSGYFT-SSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDL 1038
                    :|| ...:.:|.||.|                   ||  .|.||...:..|
 Worm   651 --------FFTIIGLAMLSLLGRV-------------------CS--YAGPLITMVAFL------ 680

  Fly  1039 QLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTY 1103
             |..|:              |:....:..||:                  .||     ...:|:.
 Worm   681 -LSSCI--------------PIGPHIIIKKSK------------------LEG-----VMAFNSL 707

  Fly  1104 IDIFVGIAVYL--CIS--VSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGS 1164
            |        :|  |:|  ||:|::        :||..: ..||.   .||.|:
 Worm   708 I--------FLPSCVSHLVSVFIL--------YRLPYS-HRCFL---FFADFV------------ 740

  Fly  1165 NVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIA 1229
                                                 ||:.:.|.:|
 Worm   741 -------------------------------------IFQVLLSLFP------------------ 750

  Fly  1230 NFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNR 1294
                           .||..::|
 Worm   751 ---------------AYGAEVYV------------------------------------------ 758

  Fly  1295 SDQQQDQEASNFIQEIKWFQDYHVEIY-LDLLLILVLVWFLN------REFEIGYRLTFYGNAVA 1352
                             .:..||:.:. :.|.|::||::|::      |:.|....::|     .
 Worm   759 -----------------GYMGYHLSVVSISLSLLVVLLFFIDWITNYERKRESACHVSF-----Q 801

  Fly  1353 NQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTAK-----YSENHHNIAIIFASIVNFNEMYDES 1412
            |::: .|:.|::...:|:.||:|..||....:..:     |:..|.|:.::||||.||.:.:.|.
 Worm   802 NEER-DVETMQDINKILIENILPSSVAAKFLSPDRAVNELYARQHENVCVMFASIPNFKDFWSEW 865

  Fly  1413 YLGGK-EFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPS--------------- 1461
            ....| |.||:|||::.:||:|||:|:|.:||||||:|||:|||:||:.|
 Worm   866 DTNRKLECLRLLNEIVCEFDKLLSKPKFSSVEKIKTVGSTYMAAAGLNESEADYDDIYLEKQNSG 930

  Fly  1462 -------HRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYY 1519
                   |......:.:.::||::||.:::||.|:|..: |..|||||::|.:.|||||..|..|
 Worm   931 KYNNNIRHGNMAFRNANLMIEFALAMSQILDALNRDSFQ-NFELRIGMSVGPLVAGVIGAQKPQY 994

  Fly  1520 DIWGDAVNVASRMDSTGLPNRIQVGKDCLPFL-TNRYEFEPRGSVYVKG-KDHMEVFLYTTRRDN 1582
            ||||:.||:|||||:.|.|.:|....|....| |..|..:.||.:.||| |:.||.||
 Worm   995 DIWGNTVNLASRMDTHGEPRKIHATTDMGRVLQTGGYRVQSRGKIRVKGVKEPMETFL------- 1052

  Fly  1583 PLDDDEADKVEQLGTKKMEHEGRDEDVVQGEQQAEDKDEEEEEEEEDDDLHSS 1635
                             :|.:.:....|.||||         ....:::.||:
 Worm  1053 -----------------IEVDSKRNSSVSGEQQ---------NHSNNNNCHST 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	96/222 (43%)
		Guanylate_cyc	361..535	CDD:278633	81/174 (47%)
		CYCc	1362..1556	CDD:214485	86/222 (39%)
		Guanylate_cyc	1388..1575	CDD:278633	88/211 (42%)
acy-2	NP_504553.1	CYCc	253..463	CDD:214485	96/233 (41%)
		Guanylate_cyc	308..459	CDD:278633	77/150 (51%)
		CYCc	817..1034	CDD:214485	86/217 (40%)
		Guanylate_cyc	840..1054	CDD:278633	90/238 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810