DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and gcy-11

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001359843.1	Gene:	gcy-11 / 181745	WormBaseID:	WBGene00001537	Length:	1168	Species:	Caenorhabditis elegans

Alignment Length:	286	Identity:	88/286 - (30%)
Similarity:	146/286 - (51%)	Gaps:	46/286 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 DPSNRILILRI---MAHLSVHLVG-VHVLIMNLV-RMRGTFMKVGQNLLVRR--QLEMEKQLKEK 309
            ||::|..|.::   :..||..|.| :...||||: |.|...    ::::..|  |||.|::..|.
Worm   870 DPASRPSIKKVRELLKPLSKGLKGNIADNIMNLLDRYRNNL----EDVIKERTEQLEDERKRNES 930

  Fly   310 MIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADI 374
            ::..::|..||:.|.|          |.|.::.:                    .::|||.|:||
Worm   931 LLLQLLPKSVANSLKN----------GQPVDAEF--------------------YDSVSIYFSDI 965

  Fly   375 VGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRAD-HAICCVE 438
            ||||.:||..|..|:|.:||:|:..||.:.....|.|:.|:||.|..|||.||..:. ||.....
Worm   966 VGFTALSSKSTPLQVVNMLNNLYTNFDTIIDKFDCYKVETIGDAYMFVSGLPEVNSYLHAGEVAS 1030

  Fly   439 MGLGMIDAMRCFDAQR--HEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPE 501
            ..|.::|:::.|....  .|.:::|:|.|||.|:.|:||.|..::.::.:.|.:||.|||||:|.
Worm  1031 ASLELLDSIKTFTVSHCPDEKLRLRIGNHTGPVVTGVVGIRMPRYCLFGDTVIIANMMESSGEPM 1095

  Fly   502 QVHISQETSSFL--GDAYYLEEGEEV 525
            ::.||.:....:  ...|..|:.|::
Worm  1096 RIQISSDAYELILKCGGYVTEQREKI 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	67/220 (30%)
		Guanylate_cyc	361..535	CDD:278633	61/170 (36%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
gcy-11	NP_001359843.1	Periplasmic_Binding_Protein_type1	<234..452	CDD:385651
		PKc_like	640..890	CDD:389743	6/19 (32%)
		CYCc	923..1116	CDD:214485	68/222 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900