Protein Alignment Ac13E and acy-4

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_504486.4
• Gene: acy-4 / 178949
• WormBaseID: WBGene00000071
• Length: 1013
• Species: Caenorhabditis elegans
• Alignment Length: 1626
• Identity: 333/1626 - (20%)
• Similarity: 543/1626 - (33%)
• Gaps: 705/1626 - (43%)

  Fly    34 ALAPHIQTYLSQTGRRHSCCSVMLPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRY--- 95
            ::..|.||.::|........|.|......:...:..:..:.:.|.|:|......||..::||
 Worm     8 SIRAHKQTRVAQRPVSKKTSSTMRETFGSQVLRELEMKNRMECPSLDEILSFYHFPWEKLRYRKN 72

  Fly    96 --------------------RFTLSYILLCSLMWCLYFVVDGGSEDFWRPISSSFSMLSLVTIMA 140
                                |...|:::|.|:  |:       ||..:....:.:....::.|:.
 Worm    73 SQKKKRSTLYSFYFEQVNSGRIQFSFVILLSI--CI-------SEAAFSAFGAEWLKSLILCILT 128

  Fly   141 LCFTHWDLYREHRT----VTSAVTALLL--CGASLAFLTYTGRAFSPLGHFAICLEIVLLIYTAL 199
            |..:....:...||    :.|.::.:::  |.:....:||.               ::...|:.|
 Worm   129 LVISILSFFHAKRTELVCIASIISCVIISACTSMRTSVTYL---------------LIFSTYSLL 178

  Fly   200 PMP--LWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRI 262
            ||.  |.:.::.|:::.:||                           .|:..:.:....|::.|:
 Worm   179 PMSFMLMIFSTFALTFLVAF---------------------------IGVLMDYNVGFDIILTRV 216

  Fly   263 MAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVA-----DM 322
            |..:.|::||..|........|.||.:..:.:..|..|:.|...:||::.:|:|..:|     ||
 Worm   217 MMVILVNVVGSLVYYPTEFVQRKTFHETRKCVQSRMLLDKEMHRQEKILLAVLPKNIAFEVKKDM 281

  Fly   323 LLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAE 387
                            .|:|..|         :|...::...|::|||||||.|||.::|....:
 Worm   282 ----------------QETHEER---------MFHKIYIRKYEDISILFADICGFTNLASEYNPK 321

  Fly   388 QLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDA 452
            .||.:||:||.|||.:.|:..|.:|..||||||||.|.||.:.:|||..||||..||:|:|....
 Worm   322 DLVLMLNELFARFDKVASIHQCMRIKILGDCYYCVCGVPEYQKNHAINTVEMGRDMIEAIRLVRE 386

  Fly   453 QRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAY 517
            .....|.||||:|||...||::|.::.:||||||||:|||:|||.|...:|||:..|.|:|..||
 Worm   387 MTLVNVNMRVGIHTGKAHCGVLGLKKWQFDVWSNDVTLANQMESGGLAGRVHITDATRSYLKGAY 451

  Fly   518 YLEEG-----------EEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQ 571
            .||||           |::   :|:.||.|..|:.                          ::.|
 Worm   452 ILEEGNGGSRSKFLEKEKI---KTWLVVDRSPDYD--------------------------NICQ 487

  Fly   572 SATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAA 636
            .|||                                                        ||.
 Worm   488 EATN--------------------------------------------------------HPV-- 494

  Fly   637 GIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKR 701
                                                ::|                 ||..|.:.:
 Worm   495 ------------------------------------MVP-----------------WKSTRGISK 506

  Fly   702 FEDLTNRSS-CGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQL 765
            .|.||..|: ..|:|:                     .|.|:.||
 Worm   507 QERLTGMSTRTRGAST---------------------RNGLSEEE-------------------- 530

  Fly   766 PVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVR 830
             ||||:                                                       :|
 Worm   531 -VLVEN-------------------------------------------------------VD-- 537

  Fly   831 SYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRAS 895
                                                                             
 Worm   538 ----------------------------------------------------------------- 537

  Fly   896 TLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRR 960
                                                                             
 Worm   538 ----------------------------------------------------------------- 537

  Fly   961 SSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPL 1025
            |.::|.|.|::
 Worm   538 SHLRQGIQAIH------------------------------------------------------ 548

  Fly  1026 AACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDF-RSKAHRFGAENET 1089
                     |.:.:.:.|                 :.:||.:|..::|..| |.|
 Worm   549 ---------QENWKTMHC-----------------KNWSLKYKQVRVENKFVRLK---------- 577

  Fly  1090 EGPPTLATPRYNTYIDIFVGIAVY-----LCISVSLFLMTQNTVSPSF--RLWVTLFSCFTGIQV 1147
                         |.||...:.:|     :||.:...||  |.||.||  ::::.|.|..
 Worm   578 -------------YKDIPFQVTLYVAIVAICIGIKFGLM--NLVSFSFVPQMFIVLTSVM----- 622

  Fly  1148 FALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPW 1212
              :|:.||.:.:..                                       |:...:..
 Worm   623 --IFILTRALIKHA---------------------------------------RLVSLVIG---- 642

  Fly  1213 HICLAVLMAMPVLLIIANF---LLLDLEQLEAFEYHYGFLIF-VCIVHFCNFTQLNCWVRNVLAF 1273
              .|.:|:::.:::::..:   ...|:|:.....|...|.|| :|.:..|....::...:.:::.
 Worm   643 --VLFILLSIQIVILMGMYESKFTCDVEKCFKNNYTDFFEIFEICTLATCVILSVDFMTKLLMSM 705

  Fly  1274 LAALCFIGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREF 1338
            :....|..:..::|:     |.:|.:        ..:..:.::.|...|.|||::    |..|..
 Worm   706 IYFSSFTVLITAKLI-----RINQYE--------ALLSTYANFCVLSCLTLLLVV----FSTRRS 753

  Fly  1339 EIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTAK-----YSENHHNIAII 1398
            |:..|..|.....|..::::::....|...:|.||:|.|||:|....|.     |.|:..|..|:
 Worm   754 ELISRYDFIWKLQALDEQLQMKRKHEQNRSVLENILPSHVAKHFVEDATSVSKLYHESRDNACIM 818

  Fly  1399 FASIVNFNEMYDE--SYLGGKEFLRVLNELIGDF----DELLSRPEFRAVEKIKTIGSTFMAASG 1457
            ||::..|::.|.|  ....|.|.||:|||:|.||    |::|.|.||:.:||||||.:|:|.|||
 Worm   819 FATLTEFDKFYIECDGNNEGVECLRLLNEIISDFDQILDQILDREEFKKIEKIKTISTTYMVASG 883

  Fly  1458 LDPSHRGTGD-EHIHTLMEFS----IAMQEV-VDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSK 1516
            |  :.|..|| .|:..:..|:    :.::.. :.:||      |..||||:|:|.|.|||||:.|
 Worm   884 L--AGRECGDNSHVEAIALFARELLVKLESTNIHSFN------NFNLRIGINVGPVVAGVIGSDK 940

  Fly  1517 LYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTN-RYEFEPRGSVYVKGKDHMEVFLYTTRR 1580
            .:|||||::|||||||||.|:..||||.::....|.. .|.||.||.:.||||..||.|......
 Worm   941 PHYDIWGNSVNVASRMDSGGVAGRIQVTEEVKSILEPLGYNFECRGQINVKGKGMMETFFLLPPE 1005

  Fly  1581 D 1581
            |
 Worm  1006 D 1006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	91/220 (41%)
		Guanylate_cyc	361..535	CDD:278633	87/184 (47%)
		CYCc	1362..1556	CDD:214485	87/211 (41%)
		Guanylate_cyc	1388..1575	CDD:278633	88/199 (44%)
acy-4	NP_504486.4	AC_N	<50..291	CDD:292831	54/316 (17%)
		CYCc	260..451	CDD:214485	89/215 (41%)
		Guanylate_cyc	293..448	CDD:278633	77/154 (50%)
		CYCc	778..984	CDD:214485	89/213 (42%)
		Guanylate_cyc	807..1003	CDD:278633	89/203 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810