DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and gcy-8

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_501324.2	Gene:	gcy-8 / 177584	WormBaseID:	WBGene00001535	Length:	1152	Species:	Caenorhabditis elegans

Alignment Length:	438	Identity:	104/438 - (23%)
Similarity:	184/438 - (42%)	Gaps:	84/438 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 TYTGRAFSPLGHFAICLEIVLLIYTALPMP---------LWL-GASTAISYSIAFEMV-----SH 222
            |.|.|....:  :|..|.:..:|:.|||.|         .|| ..|..:..:|....|     |.
Worm   768 TQTRRQLGDV--YAFGLVMYEIIFRALPFPEGTNQSELVEWLRDGSKVVKPTIPQNKVLNMDLSA 830

  Fly   223 MVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTF 287
            ::..|                     .|..|..|..:.||..::..:|.....|:..:.||...:
Worm   831 LIQDC---------------------WNTTPEMRPSLRRIKLNVETYLNIKGSLVDQMTRMMEQY 874

  Fly   288 MKVGQNLLVRR--QLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASN 350
            ....:.|:..|  .||...|..::::..::|..||                             |
Worm   875 ANNLEKLVAERTGMLEEANQRADRLLSQLLPAYVA-----------------------------N 910

  Fly   351 DVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTL 415
            ::| |.||....:..:.::||:||||||.|....:..::|.:||.:|:.||...:.....|:.|:
Worm   911 ELK-LGRPVPPKTFTSSTVLFSDIVGFTEMCQNASPLEVVAVLNGIFDGFDQFIARKDAYKVETI 974

  Fly   416 GDCYYCVSGCPEP---RADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTR 477
            ||.|..|||.||.   |..:.|..:.:.:....:......:|...|:.|:|.|||.|...:||..
Worm   975 GDAYMVVSGVPEENGHRHINEIASIALDVHKFLSEFIVPHKRDTKVQCRLGFHTGPVAAAVVGLN 1039

  Fly   478 RVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAY--YL--EEGE-EVFGH---RTYFVV 534
            ..::.::.:.|::|::|||:.:|.:..||:...:.|...|  |:  :.|| .:.|.   .||:::
Worm  1040 APRYCLFGDTVNMASRMESNSEPGKTQISETAKNLLLKEYPDYICEQRGEIPIKGKGLCMTYWLM 1104

  Fly   535 GRRRDFTRTNS--LSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQ 580
            |.:.:.:..:.  |:|||.:..||.:.:| |......|.:..|.:.:|
Worm  1105 GTKSEGSGRSGAYLAPSMKSAGTGFTGML-GNSANDYSLNLKNPTGLQ 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	56/220 (25%)
		Guanylate_cyc	361..535	CDD:278633	53/184 (29%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
gcy-8	NP_501324.2	ANF_receptor	87..442	CDD:279440
		Periplasmic_Binding_Protein_Type_1	94..434	CDD:299141
		PKc_like	558..850	CDD:304357	21/104 (20%)
		HNOBA	<866..912	CDD:285003	11/74 (15%)
		CYCc	891..1084	CDD:214485	57/222 (26%)
		Guanylate_cyc	918..1105	CDD:278633	53/186 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900