DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and acy-1

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_497970.1	Gene:	acy-1 / 175622	WormBaseID:	WBGene00000068	Length:	1253	Species:	Caenorhabditis elegans

Alignment Length:	1678	Identity:	485/1678 - (28%)
Similarity:	698/1678 - (41%)	Gaps:	580/1678 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 RRHSCCSVMLPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLY 112
            |.||.....:|: ||||:|: |.:|:|.|..||.||....|..:|.|:|..|.||.:....|.||
Worm    21 RAHSSSPRRVPL-FERASAR-WWNPQFRSATLEAQYWKCSFSQLRDRFRSGLIYIAVVIAAWTLY 83

  Fly   113 FVV-DGGSEDFWRPISSSFSMLSLVTIMALC----------FTHWDL-YREHRTVTSAVTALLLC 165
            ..: |......|              |::||          ||.... |:.....||.:...|:|
Worm    84 LALFDRTFIQHW--------------IVSLCLCAIIFAMFAFTACAAQYQRFYMPTSFLCTFLIC 134

  Fly   166 GASLAFLTYTGRA--FSPLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIGCS 228
            ..:|...:...:|  .:|:...|...::||||||.:|:||:|.....|.|||.||:::...|
Worm   135 LVTLLIFSAENQAAFMTPVASLATSFQVVLLIYTVIPLPLYLCILIGIIYSILFEILNKNKI--- 196

  Fly   229 AIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQN 293
                             |:|..|       .::::.|..|||:|||:.|:..||.|.||:||||:
Worm   197 -----------------GLEEAG-------YIKLVLHAGVHLLGVHLFILTQVRQRKTFLKVGQS 237

  Fly   294 LLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASND------- 351
            :|.|:.||:|.|.|:.||.||||.||||.||.:.             |...||.||||
Worm   238 MLARKDLELETQFKDHMIQSVMPKKVADELLKDA-------------SELRRPSASNDSNCRTSN 289

  Fly   352 --------VKSL-----FRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDL 403
                    .|.:     ||||.|:.|.|||||||||.|||:|||.|:|::||.:|||||.|||.|
Worm   290 ATQVDQPLAKMVPEYRKFRPFTMNLMTNVSILFADIAGFTKMSSNKSADELVNLLNDLFGRFDTL 354

  Fly   404 CSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGT 468
            |.|.|.|||||||||||||:|||||..|||...|||||.||.|:|.||..|.:.|.||||:|||.
Worm   355 CRLRGLEKISTLGDCYYCVAGCPEPCDDHACRTVEMGLDMIVAIRQFDIDRGQEVNMRVGIHTGK 419

  Fly   469 VLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFG------ 527
            |:||:|||:|.||||:||||:|||:|||||...:||:|:.|:..|...|.:|||.:..|
Worm   420 VMCGMVGTKRFKFDVFSNDVTLANEMESSGVAGRVHVSEATAKLLKGLYEIEEGPDYDGPLRMQV 484

  Fly   528 -----------HRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQP 581
                       .:|:|:.||..|                            .:.:....|..|:
Worm   485 QGTERRVKPESMKTFFIKGRIND----------------------------GVEEEVMQVQEVE- 520

  Fly   582 NVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVER-GIIHPAAAGIPPVIVVR 645
                         ||:              |.|..|||..:.:..|: .:.|
Worm   521 -------------SLH--------------SQKSSKKSTLKQKWAEKLKMNH------------- 545

  Fly   646 ERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSS 710
                    |.|.                  |....|.|....:::|:
Worm   546 --------TNSY------------------PMRAAAREGGGSLRIKL------------------ 566

  Fly   711 CGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRT 775
                         .||.|.         .||.|:|:.:.          |       ::|.|.::
Worm   567 -------------AERNRS---------TQLLPKESNSI----------C-------IMEDNRKS 592

  Fly   776 QTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDI 840
            .:|.               |||::
Worm   593 ASLQ---------------ALATN----------------------------------------- 601

  Fly   841 SPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPN 905
               ..:||........|..||.|:    |..:..||:       |.:.:...|:|.|..
Worm   602 ---NFNGSNTDTNNTYSERGVAGS----VSKKSVAGS-------ESNSIKGSRSSGLQL------ 646

  Fly   906 SLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYAL 970
            ||:.|.|..         |||||
Worm   647 SLQDGNSDL---------NSVGG------------------------------------------ 660

  Fly   971 NQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQ 1035
            ..||||.|                                                        .
Worm   661 LDTAISHH--------------------------------------------------------H 669

  Fly  1036 SDLQLIRCVRDNARSQRSYLV---------------KPPLRKFSLYFKSRQLERDFRS------- 1078
            :...|.|...||...||..:|               ...|.|::|.|..:.:|.::|:
Worm   670 NAASLTRFDTDNNFDQRLAMVIGQGEGGFDKGFWNHHDSLNKWTLRFNEKDVEEEYRAHFVDSSE 734

  Fly  1079 ------KAH--------RFGAENETEGPPTLATPRYN-TYIDIFVGIAVYLCISVSLFLMTQNTV 1128
                  |.|        ..|.|.:.....|:...||: .:|||.|...::: ||.::.:|   :|
Worm   735 RYTASKKGHVERHKDLMEQGGEKDGITGSTVNKYRYSGVFIDIIVATLIFV-ISGAVAIM---SV 795

  Fly  1129 SPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRP 1193
            .|.....:..|.....|.:..:.|....:..|:
Worm   796 RPFPLSLIAYFPFAAAILILTIVLIGLPLLARK-------------------------------- 828

  Fly  1194 HFESCADRIFEAISSWYPWHICLAVLMAMPVLLII-----------ANFLLLDLEQLEAFEYHYG 1247
                   :.|:..:.|.|.|:...:|:.:|:.:.|           ||.:|       .:...:.
Worm   829 -------KSFQCANQWMPRHLIGLLLIFLPIGVAICIMPLCQSGDCANVIL-------NYRLAFS 879

  Fly  1248 FLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIA-VSQLMVYSHNRSDQQQDQEASN----FI 1307
            ::..:.|...|||:||..|.:.     .|..|||:. ::.:.....|.....::|:..|    .|
Worm   880 YVTILAIFAHCNFSQLAAWPKT-----TAAVFIGLLHIAGVFYCEFNLKHLVEEQDTCNVTAIMI 939

  Fly  1308 QEIKWFQDYHV---------------------EIYLDLLLILVLVWFLNREFEIGYRLTFYGNAV 1351
            ..|:...:|.:                     |:.||::|.:|||.|||.:||..:|::|:|:..
Worm   940 PPIRKGLNYTIALNSTSARTLSQDFGSPLFIWELLLDVILSIVLVAFLNYQFETAFRMSFFGDVQ 1004

  Fly  1352 ANQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTAKYSENHHNIAIIFASIVNFNEMYDESYLGG 1416
            |.:|..|:|.:::|||.||:|:||.|..|.||...||||||..:.::||||.|:|:||:|::.||
Worm  1005 ARRDTERMQIVRDQADWLLNNVIPAHAVESLKTDTKYSENHETVGVLFASITNWNDMYEENFEGG 1069

  Fly  1417 KEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGT---GDEHIHTLMEFSI 1478
            :||||||||:||||||||.||:|..:|||||||..:||||||:|..:..   ..||::.:::|::
Worm  1070 REFLRVLNEVIGDFDELLDRPDFTHIEKIKTIGPAYMAASGLNPERKKNMLHPKEHLYQMVDFAL 1134

  Fly  1479 AMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQV 1543
            |:|.|:..||:|||.|:.:.::|:|||.||||||||:|||||||||.||:||||.|||:.|||||
Worm  1135 AVQHVLSVFNEDLLNFDFVCKLGLNIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRIQV 1199

  Fly  1544 GKDCLPFLTNRYEFEPRGSVYVKGKD-HMEVFLYTTRRDN----PLDDDEADK 1591
            .:....:|.:|||||.|..:.|||.| .|:.:|...|:.:    .:.|::.|:
Worm  1200 SQHTREYLLDRYEFEFRDHIEVKGIDGGMDTYLLVGRKGDGIPPSIKDNQEDE 1252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	129/235 (55%)
		Guanylate_cyc	361..535	CDD:278633	109/190 (57%)
		CYCc	1362..1556	CDD:214485	111/196 (57%)
		Guanylate_cyc	1388..1575	CDD:278633	108/190 (57%)
acy-1	NP_497970.1	MreD	127..>223	CDD:294686	34/122 (28%)
		CYCc	297..469	CDD:214485	107/171 (63%)
		Guanylate_cyc	317..503	CDD:278633	107/185 (58%)
		SDF	<773..982	CDD:294387	44/263 (17%)
		CYCc	1016..1215	CDD:214485	114/198 (58%)
		Guanylate_cyc	1041..1235	CDD:278633	109/193 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166210
Domainoid	1	1.000	227	1.000	Domainoid score	I1422
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H868
Inparanoid	1	1.050	658	1.000	Inparanoid score	I402
Isobase	1	0.950	-	0	Normalized mean entropy	S6595
OMA	1	1.010	-	-		QHG49383
OrthoDB	1	1.010	-	-		D207369at33208
OrthoFinder	1	1.000	-	-		FOG0006877
OrthoInspector	1	1.000	-	-		oto18325
orthoMCL	1	0.900	-	-		OOG6_106616
Panther	1	1.100	-	-	LDO	PTHR45627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3771
SonicParanoid	1	1.000	-	-		X5766
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750