DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and gcy-29

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001364597.1	Gene:	gcy-29 / 175116	WormBaseID:	WBGene00007314	Length:	1069	Species:	Caenorhabditis elegans

Alignment Length:	306	Identity:	82/306 - (26%)
Similarity:	139/306 - (45%)	Gaps:	53/306 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 PSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMK-----VGQNLLVRRQLEMEKQLK-EKMI 311
            |..|..|.|:.....:.|.....|:.:::||...:..     ||:    |.:|..|..|: |:::
Worm   789 PDMRPTIRRVRLATEIALKTKGNLVDSMMRMMEEYANNLEKLVGE----RTKLAEEANLRAERLL 849

  Fly   312 HSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVG 376
            ..::|..||         ..|.||.......|                     ::.:::|:||||
Worm   850 FQLLPKHVA---------IELKAGRTVAPKMY---------------------DSATVMFSDIVG 884

  Fly   377 FTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCP-EPRADHAICCVEMG 440
            ||::.|..|..::|.:||.|:..||.:.|...|.|:.|:||.|..|||.| |....|......:.
Worm   885 FTKLCSASTPIEVVNLLNKLYSEFDTVISKHDCYKVETIGDAYMVVSGIPIENGQRHVANISAVT 949

  Fly   441 LGMIDAMRCFDA--QRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQV 503
            ||::|.::.|:.  :|...:.:|:|..:|.|...:||....::.::...|::|..|||||:..:|
Worm   950 LGIMDLLKVFEVPHRRDYRLTIRLGFASGQVSAAVVGLSSPRYCLFGETVNIAAVMESSGEGGRV 1014

  Fly   504 HISQETSSFLGDAYYLEEGEEVFGHR---------TYFVVGRRRDF 540
            .|: |||..|.:..|.|...|:.|..         ||::.|:..|:
Worm  1015 QIT-ETSKILLENEYPEFIIEIRGINKDVKQDDFVTYWLTGKDEDY 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	62/219 (28%)
		Guanylate_cyc	361..535	CDD:278633	58/185 (31%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
gcy-29	NP_001364597.1	PBP1_NPR_GC-like	27..403	CDD:380575
		PKc_like	534..804	CDD:419665	4/14 (29%)
		CYCc	840..1033	CDD:214485	64/223 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900