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Protein Alignment Ac13E and gcy-12

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_494995.2	Gene:	gcy-12 / 173902	WormBaseID:	WBGene00001538	Length:	1679	Species:	Caenorhabditis elegans

Alignment Length:	817	Identity:	172/817 - (21%)
Similarity:	291/817 - (35%)	Gaps:	231/817 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 HLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEM--EKQLKEKMIHSVMPPKVADMLLNEGGPSG 331
            |.:....::.::|.|...:....::|:..|.:|:  |::..:.::..::|..||:.||     :|
Worm   956 HQIYKQNIMDHMVLMMEKYQTQLEDLVDERTIELKDEQRRSQHLLQRMLPSSVAEQLL-----AG 1015

  Fly   332 LDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDL 396
            .|   :.||:              |.|        |:|.|:||||||.:|...|..::|..||.|
Worm  1016 QD---VIPEA--------------FPP--------VTIYFSDIVGFTTISGESTPMEVVTFLNKL 1055

  Fly   397 FERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRA--DHAICCVEMGLGMIDAMRCFDAQRH--EG 457
            :..||.:.......|:.|:||.|..|||.|:.:.  .||.....|.:.::.|:|.|.....  |.
Worm  1056 YTLFDSIIRRYDVYKVETIGDAYMVVSGVPQYKTMEYHAEQIAMMAIHILSAVRSFSIPHRSCEP 1120

  Fly   458 VKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFL---GDAYYL 519
            :.:|:|:|||..:.|:||....::.::.:.|:.|::|||:|:..::|.|..|...|   ...:.|
Worm  1121 LMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVNTASRMESNGEALRIHCSSSTQKVLTSIDQGFLL 1185

  Fly   520 EEGEEVF----GHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQ 580
            ||...:.    |..|.:.:..|..:..|.::...|                            |.
Worm  1186 EERGSLAIKGKGQMTTYWLNGRAGYEFTETIEDKM----------------------------VV 1222

  Fly   581 PNVPPASPVGQLSSS--LNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIH---PAAAG--- 637
            |::.|...:....||  :|....||:....:|..||.:..:.:|:   .:.:|:   |..:|
Worm  1223 PDIFPRPNLKNRGSSWGVNRESSLSLATEKSSQIMKRQSAAMNRN---NQDVIYYNQPLNSGGFT 1284

  Fly   638 -------IPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKI 695
                   ..|.:...:|..::..:.||.||                      .|..:.|....|.
Worm  1285 SRGTSNREMPKLYEEDRESLLNQSASLLGS----------------------RTSGRKKSTASKY 1327

  Fly   696 PRF--LKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPE--ETLAFMDNQMQN 756
            ..|  .:.|....:.:|....|.....|.:....| |....|....:||.|  ||....:|
Worm  1328 NGFSASRMFSSTISNASSSRPSRPSTFDHDTLALR-KRSTSLPDGEKLNLEFIETTNLANN---- 1387

  Fly   757 GNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYS 821
                   .:|.:..        :|.:..||...|:..... ||...||           |..||.
Worm  1388 -------SVPAIPN--------NISSLEPVFRKASIIDGY-SSQSESP-----------SQSQYP 1425

  Fly   822 MYDDIIDVRSYISQSRSDISPFGRSGSYRS-QCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVE 885
            .|.|:........:..:.:.|..:    || .||        .|.|..:...|.:|:..||
Worm  1426 SYRDLTTGPHQRKRGIATVFPVRK----RSLSCG--------DAVPLKINENGASGSITTA---- 1474

  Fly   886 QSPLPRPRASTLATGRPTPNSLEPGPSSTSP-----------------CCLPAPGNSVGGGGI-- 931
                ..||:|..|.. ||   ::....::||                 ..|.:.|||.....:
Worm  1475 ----VSPRSSCRALD-PT---MKLAARASSPDEIIFQEDDEDALIDNDSLLTSNGNSKSEDVLRT 1531

  Fly   932 --FPPTHSRQSSI---CPSATSRKD-----------SGIKSNSRRSSIQQQIYAL---------N 971
              .|...::.|.:   .|.|...:|           :..|||...||....|..|         |
Worm  1532 CPQPRRKNKHSFLRDPSPLAKRFRDASPFGKKKPFWNSNKSNEHTSSPADSISRLFRRFRGGSVN 1596

  Fly   972 QTAISQH---------RVSGYFTSSTSSISNLGEVQG 999
            :.|...|         |.:||      .:..:|::.|
Worm  1597 EYADLNHYCDDEDESGRANGY------EMQEMGKMTG 1627

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.