DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and gcy-28

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001021600.1	Gene:	gcy-28 / 172051	WormBaseID:	WBGene00020131	Length:	1276	Species:	Caenorhabditis elegans

Alignment Length:	271	Identity:	85/271 - (31%)
Similarity:	142/271 - (52%)	Gaps:	41/271 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 LIMNLVRMRGTFMKVGQNLLVRRQLE--MEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLP 338
            |:.||::....:....:.|:..|..|  .||:..|:::|.::||.:||.|:         ||
Worm  1022 LVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLI---------AG--- 1074

  Fly   339 PESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDL 403
                              |.....|.:.|:|.|:||||||.:||..|..|:|.:||||:..||.:
Worm  1075 ------------------RAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGV 1121

  Fly   404 CSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQR--HEGVKMRVGVHT 466
            .......|:.|:||.|..|||.||.|.|||....:|.|.::..::.|..:.  ||.:|:|:|:|:
Worm  1122 VDNFKVYKVETIGDAYMVVSGLPERRDDHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHS 1186

  Fly   467 GTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFL----GDAYYLEEGEEVFG 527
            |:|:.|:||::..::.::.:.|:.:::|||:|.|.::|:||:|...|    |....|....|:.|
Worm  1187 GSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKG 1251

  Fly   528 ---HRTYFVVG 535
               ..||::.|
Worm  1252 KGMQTTYWLRG 1262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	73/221 (33%)
		Guanylate_cyc	361..535	CDD:278633	66/182 (36%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
gcy-28	NP_001021600.1	PBP1_NPR_like	42..486	CDD:107368
		ANF_receptor	64..465	CDD:279440
		PK_GC-A_B	722..1016	CDD:270944
		STYKc	741..1008	CDD:214568
		HNOBA	<1026..1071	CDD:285003	12/44 (27%)
		CYCc	1050..1233	CDD:214485	71/212 (33%)
		Guanylate_cyc	1077..1262	CDD:278633	66/184 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910