Protein Alignment Ac13E and Gucy2c

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_001120790.1
• Gene: Gucy2c / 14917
• MGIID: 106903
• Length: 1072
• Species: Mus musculus
• Alignment Length: 1141
• Identity: 229/1141 - (20%)
• Similarity: 385/1141 - (33%)
• Gaps: 320/1141 - (28%)

  Fly   703 EDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQ----LNPEETLA----FMDNQM----- 754
            :.|.::|....||:...||..||..|:        |..    :.|..|.:    ::|.::
Mouse    86 DGLIHKSGDCRSSTCEGLDLLREITRD--------HKMGCALMGPSCTYSTFQMYLDTELNYPMI 142

  Fly   755 ---QNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASS----------------- 799
               ..|..|.|::          |.|..:|.||.:::.......:.::
Mouse   143 SAGSYGLSCDYKE----------TLTRILPPARKLMYFLVDFWKVNNASFKPFSWNSSYVYKNGS 197

  Fly   800 -------VLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQS---RSDISPFGRSGSYRSQCG 854
                   .|.:.||||            |.:.::::.:..:.:|   :..::...|..:....||
Mouse   198 EPEDCFWYLNALEAGV------------SYFSEVLNFKDVLRRSEQFQEILTGHNRKSNVIVMCG 250

  Fly   855 R-QSTGGVNGAGPAGVGAEGRA------------GTSQTAP-----------PVEQSPLPRPRAS 895
            . :|...|.|....   ||...            ..:.|||           |.|||......|.
Mouse   251 TPESFYDVKGDLQV---AEDTVVILVDLFSNHYFEENTTAPEYMDNVLVLTLPSEQSTSNTSVAE 312

  Fly   896 TLATGRP----------------TPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICP 944
            ..::||.                ....||.|.:.|.|....|..|....|...|.|
Mouse   313 RFSSGRSDFSLAYLEGTLLFGHMLQTFLENGENVTGPKFARAFRNLTFQGFAGPVT--------- 368

  Fly   945 SATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRV-SGYFTSSTSSI-----SNL--------G 995
                ..|||...|     |...:|....|  .:::| ..|.|....:|     .|.        .
Mouse   369 ----LDDSGDIDN-----IMSLLYVSLDT--RKYKVLMKYDTHKNKTIPVAENPNFIWKNHKLPN 422

  Fly   996 EVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPL 1060
            :|.|||        |.:||.|..:     |...|..|...:.|.|.:..||:|..|:.:...|..
Mouse   423 DVPGLG--------PQILMIAVFT-----LTGILVVLLLIALLVLRKYRRDHALRQKKWSHIPSE 474

  Fly  1061 RKFSL----------------------------YFKSRQLERDFRSKAHRFGAENETEGPPTLAT 1097
            ..|.|                            |.|.:.:.:|.:.....|..:.:.:....|.:
Mouse   475 NIFPLETNETNHISLKIDDDRRRDTIQRVRQCKYDKKKVILKDLKHSDGNFSEKQKIDLNKLLQS 539

  Fly  1098 PRYN-------TYID--IFVGIAVYLCISVSLFLMTQNTVS---PSFRLWVTLFSCFTGIQVFAL 1150
            ..||       ..:|  || |:..| |...||..:..:|:|   .:|..|....|....|.....
Mouse   540 DYYNLTKFYGTVKLDTRIF-GVVEY-CERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMS 602

  Fly  1151 FLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCA--DRIFEAISSWYPWH 1213
            :|.:         |.:....|.|||                     :|.  .|:...|:.:.
Mouse   603 YLHS---------SKIEVHGRLKST---------------------NCVVDSRMVVKITDFG--- 634

  Fly  1214 ICLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAF----- 1273
             |.::|.....|......|.......:...|.:..:....|:....|..|:|...|...|
Mouse   635 -CNSILPPKKDLWTAPEHLRQATISQKGDVYSFAIIAQEIILRKETFYTLSCRDHNEKIFRVENS 698

  Fly  1274 ----LAALCFIGIA-VSQLMVYSHNRSDQQQDQEASNFIQEIK--------WFQDYHVEIYLDLL 1325
                .....|:..| ..:|.||...:|..::|.|.....::|:        .|.|...|.|:|.|
Mouse   699 YGKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTL 763

  Fly  1326 LILVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTAKYS- 1389
            :..:.::..|.|..:..|...|   .|.:|:         ||.|...::|:.|.:.||......
Mouse   764 IRRLQLYSRNLEHLVEERTQLY---KAERDR---------ADHLNFMLLPRLVVKSLKEKGIVEP 816

  Fly  1390 ENHHNIAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMA 1454
            |.:..:.|.|:.||.|..:.  .|....|.:.:||::...||:::...:   |.|::|||..::.
Mouse   817 ELYEEVTIYFSDIVGFTTIC--KYSTPMEVVDMLNDIYKSFDQIVDHHD---VYKVETIGDAYVV 876

  Fly  1455 ASGLDPSHRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLE-FNLILRIGMNIGDVTAGVIGTSKLY 1518
            ||||...:   |:.|...:.:.::.:...:..|..:.|. ..:.:|||::.|...|||:|.....
Mouse   877 ASGLPMRN---GNRHAVDISKMALDILSFIGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPR 938

  Fly  1519 YDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTN---RYEFEPRGSVYVKGKDHMEVFLYTTRR 1580
            |.::||.||.||||:|||||.||.:....:..|..   ::.:|.||..|:||:.....:..|
Mouse   939 YCLFGDTVNTASRMESTGLPLRIHMSSSTITILKRTDCQFLYEVRGETYLKGRGTETTYWLT--- 1000

  Fly  1581 DNPLDDDEADKVEQLGTKKMEHEGRDEDVVQGEQQAEDKDEEEEEEEEDDDLHSSETTTLFKSQE 1645
                           |.|..|:.......|:.:|:                |.:..:..:..:.:
Mouse  1001 ---------------GMKDQEYNLPSPPTVENQQR----------------LQTEFSDMIVSALQ 1034

  Fly  1646 SLQANGGSHLAPNAAATSHTHTITL--TNNNNHNSS 1679
            ..||:|.....|...|:.....:..  .||::|:|:
Mouse  1035 KRQASGKKSRRPTRVASYKKGFLEYMQLNNSDHDST 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485
		Guanylate_cyc	361..535	CDD:278633
		CYCc	1362..1556	CDD:214485	57/198 (29%)
		Guanylate_cyc	1388..1575	CDD:278633	56/191 (29%)
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_Type_1	35..415	CDD:299141	68/381 (18%)
		PKc_like	480..749	CDD:304357	50/304 (16%)
		STYKc	502..744	CDD:214568	50/277 (18%)
		CYCc	787..978	CDD:214485	59/207 (29%)
		Guanylate_cyc	814..1001	CDD:278633	57/212 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810