DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and gucy2f

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_571939.2	Gene:	gucy2f / 140424	ZFINID:	ZDB-GENE-011128-7	Length:	1107	Species:	Danio rerio

Alignment Length:	283	Identity:	80/283 - (28%)
Similarity:	143/283 - (50%)	Gaps:	50/283 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 LIMNLVRMRGTFMKVGQNLLVRR--QLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLP 338
            :|.:::||...:....::|:..|  :||:|||..||::..::||.||:.|..          |..
Zfish   821 IIDSMLRMLEQYSSNLEDLIRERTEELEVEKQRTEKLLSEMLPPSVAEALKT----------GAS 875

  Fly   339 PESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDL 403
            .|..|                    .:.|:|.|:||||||.:||.....::|::||||:..||.:
Zfish   876 VEPEY--------------------FDQVTIYFSDIVGFTTISSLSDPIEVVDLLNDLYSLFDAV 920

  Fly   404 CSLSGCEKISTLGDCYYCVSGCPEPRAD-HAICCVEMGLGMIDAMRCFDAQRH---EGVKMRVGV 464
            .......|:.|:||.|...||.|:...: ||.....|.|.::.::..| ..||   ..|::|:|:
Zfish   921 LGSHDVYKVETIGDAYMVASGLPKKNGNKHAAEIANMSLNILSSVGSF-KMRHMPEVPVRIRIGI 984

  Fly   465 HTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSF---LGDAYYLE------ 520
            |:|..:.|:||....::.::.:.|:.|::|||:|.|.::|::..|...   |.|.|.::
Zfish   985 HSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNISTVQILRSLNDGYKIDVRGKTE 1049

  Fly   521 -EGEEVFGHRTYFVVGRRRDFTR 542
             :|:.:  ..||::|| :.:||:
Zfish  1050 LKGKGI--EETYWLVG-KANFTK 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	65/222 (29%)
		Guanylate_cyc	361..535	CDD:278633	56/187 (30%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF_like	59..440	CDD:107366
		PK_GC-2D	551..816	CDD:270945
		HNOBA	<825..870	CDD:311573	15/44 (34%)
		CYCc	850..1042	CDD:214485	66/222 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810