Protein Alignment Ac13E and LOC1272957

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_061519369.1
• Gene: LOC1272957 / 1272957
• VectorBaseID: AGAMI1_006876
• Length: 1413
• Species: Anopheles gambiae
• Alignment Length: 1555
• Identity: 354/1555 - (22%)
• Similarity: 506/1555 - (32%)
• Gaps: 720/1555 - (46%)

  Fly   119 SEDFWRPISSS--FSML----SLVTIMALCFTHW-------------DLYREHRTVTSAVTALLL 164
            |||...|:.:.  |::|    :.:.::.:|.|.:             ::|....:....||.|:|
Mosquito   471 SEDGDIPLCNRDYFTLLKDNMTQIIVLGVCATVYALLLMCLYKQRINEIYLFQVSYVIMVTLLVL 535

  Fly   165 CGASLAF-LTYTGRAFSPLGHFAICLEI-VLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIGC 227
               .:.| .|.:.:.|:..|.   |..| :.:|||.||:.|   ....:..|:.  .:||:.:
Mosquito   536 ---DVCFSFTTSAKKFTSSGG---CTVIAIYIIYTMLPIRL---REAVVGGSLL--SISHIAL-- 587

  Fly   228 SAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQ 292
                              ....|......:|...::.....:..|:.:........|..||:..|
Mosquito   588 ------------------MFYMNESDDMDVLYCDLITLACTNATGILLHWPKEKSQRKAFMETRQ 634

  Fly   293 NLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFR 357
            .:..|.:::.|.|.:|:::.||:|..||..:.|       |..|.|.|:.             |.
Mosquito   635 CVEARLKIQRENQKQEQLLLSVLPRHVAMEMKN-------DIAGQPREAQ-------------FH 679

  Fly   358 PFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCV 422
            ..::...||||||||||.|||.:|...|||:||.:||:||.|||.|.....|.:|..||||||||
Mosquito   680 KIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAQEHHCLRIKLLGDCYYCV 744

  Fly   423 SGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSND 487
            ||.||.|.|||:|.|||||.||||:..........|.||||:|||.|.||::|.|:.:|||||||
Mosquito   745 SGLPEARPDHALCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLRKWQFDVWSND 809

  Fly   488 VSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPA 552
            |:|||.|||.|.|.:|||::||...|||.|.:|||
Mosquito   810 VTLANYMESGGVPGRVHITKETLRCLGDHYDVEEG------------------------------ 844

  Fly   553 NATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRK 617
                                                                             
Mosquito   845 ----------------------------------------------------------------- 844

  Fly   618 KSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAA 682
                      ||                                                    |
Mosquito   845 ----------RG----------------------------------------------------A 847

  Fly   683 ETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETL 747
            :..|.:|
Mosquito   848 DRNSYLK---------------------------------------------------------- 854

  Fly   748 AFMDNQMQNGNGCGYQQLPVLVESNHRTQT-LDIPAARPVLHHAATSTALASSVLRSPEAGVSGG 811
                                    :|:.|| |.:|
Mosquito   855 ------------------------DHQIQTYLIVP------------------------------ 865

  Fly   812 GGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAG 876
                                             :..|||
Mosquito   866 ---------------------------------KDASYR-------------------------- 871

  Fly   877 TSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSS 941
                                                                    |.|.|:|||
Mosquito   872 --------------------------------------------------------PHTMSKQSS 880

  Fly   942 ICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGY-----FTSSTSSISNLGEVQGLG 1001
                                       ::|.....:.|:.|:     |...|...|...||.
Mosquito   881 ---------------------------SVNGNISKELRMMGHWSKMGFNDKTEPKSTEEEVN--- 915

  Fly  1002 LPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLY 1066
                     ..|:.|..::..|             .|:|..|                 ::|.|.
Mosquito   916 ---------EYLIKAIDARSID-------------RLRLDHC-----------------KRFHLT 941

  Fly  1067 FKSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTY----IDIFVGIAVYLCISVSLFLMTQNT 1127
            |...::||       ::..|.:         |..|.|    |.||:||   :.|.|.:|.|..
Mosquito   942 FIKDEIER-------KYCLEPD---------PMLNVYFYCSIIIFLGI---MSIQVLVFSMDH-- 985

  Fly  1128 VSPSFRLWV-------TLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDER 1185
                :..||       .|.||   :.||                           |.||::
Mosquito   986 ----YSYWVYGILSLTLLVSC---VPVF---------------------------TREDMK---- 1012

  Fly  1186 GAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYGFLI 1250
                         ....|.|:|.....|..:|.::::.|::.:.           ...|:...||
Mosquito  1013 -------------VSTFFRALSQKIHGHREIAQVISLCVVITVI-----------CLSYYKLTLI 1053

  Fly  1251 FVCIVH--FCNFTQLNC---WVRNVLAFLAALCFIGIAVSQLMVYSHNRSDQQQDQEASNFIQEI 1310
            |...::  |......||   .:.|:|..|..|..:..||.|                   ||:
Mosquito  1054 FYLSLYDEFPLVRPSNCKESKIINILLLLTLLALLTCAVHQ-------------------FIK-- 1097

  Fly  1311 KWFQDYHVEIYLDLLLILVLV-------------------WFLNRE-----------FEIGY--- 1342
                    .::..||||::||                   |||..|           |.||.
Mosquito  1098 --------ILFKILLLIVILVLYIASIIVLALIFERHCEPWFLTTERFLIDVAFLVVFVIGQIMH 1154

  Fly  1343 --------RLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHL----KNTAK-YSENHHN 1394
                    ||.|.....|.::|..:::::.....||.||:|.|||:|.    ||..: |.|....
Mosquito  1155 SQQTEITRRLDFIWKLQATEEKEDMEHLQAYNRKLLANILPVHVADHFLMREKNIEEIYHEQCDT 1219

  Fly  1395 IAIIFASIVNFNEMYD--ESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASG 1457
            :.::||||.||:|.|.  |....|.|.||:|||:|.||||||....||.||||||.|||:|||||
Mosquito  1220 VCVMFASIPNFSEFYIELEGNNEGVECLRLLNEIIVDFDELLGLERFRYVEKIKTTGSTYMAASG 1284

  Fly  1458 LDPSHRGTGD-EHIHTLMEFSIAM-QEVVD----AFNKDLLEFNLILRIGMNIGDVTAGVIGTSK 1516
            |..:.....| :|:..:|::::.: |::.|    :||      |..:|||:|||.|.||||||.|
Mosquito  1285 LTANSCDKNDFQHVFAMMDYALELFQKITDVNEHSFN------NFRMRIGINIGPVVAGVIGTRK 1343

  Fly  1517 LYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNR-YEFEPRGSVYVKGKDHMEVFL 1575
            ..|||||:|||||||||||||.:.|||.:|....:.:: |....||:|.||||..|..:|
Mosquito  1344 PQYDIWGNAVNVASRMDSTGLMDHIQVTEDVYQIVKDKGYNLTCRGTVNVKGKGTMITYL 1403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	106/215 (49%)
		PHA03307	836..>1015	CDD:223039	18/183 (10%)
		Guanylate_cyc	1388..1575	CDD:425528	95/195 (49%)
LOC1272957	XP_061519369.1	None