DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and LRRK2

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens

Alignment Length:	1246	Identity:	223/1246 - (17%)
Similarity:	377/1246 - (30%)	Gaps:	529/1246 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 GMEANGDPSNRILILRIMAHLSVHLV------GVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEK 304
            |.|....|::|.::|.::.|.|...|      .:..|:...|..|...:..|.:|.|       .
Human   389 GDEDGHFPAHREVMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHLNV-------L 446

  Fly   305 QLKEKMIHSVMPPKVAD---MLLN---EGGPSGLD------------------------------ 333
            :|.:|.|||   |:||:   .:||   ||..:.||
Human   447 ELMQKHIHS---PEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPVQLEALRAI 508

  Fly   334 ----AGGLPPESHYMRPRASNDVKSLFRPFHMHSMENV----------SILFADIVGF-----TR 379
                ..|:|.||.       .|.:     || |.:..|          .::.|.:..|     .:
Human   509 LHFIVPGMPEESR-------EDTE-----FH-HKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQ 560

  Fly   380 MSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMI 444
            ....|....:|...:.|     ::.||.|     .:....:.:...|:   |..|.|  :||.:|
Human   561 KCGLKVISSIVHFPDAL-----EMLSLEG-----AMDSVLHTLQMYPD---DQEIQC--LGLSLI 610

  Fly   445 DAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLAN-----------KMESSG 498
            ..:.         .|..|.:.||.:|..|:.:...:|    .||:...           |:.:|.
Human   611 GYLI---------TKKNVFIGTGHLLAKILVSSLYRF----KDVAEIQTKGFQTILAILKLSASF 662

  Fly   499 KPEQVH------ISQETSSFLGDAYYLEEGEEVFGHR--TYFVVGRRRDFTRTNSLSPSMPANAT 555
            ....||      |..:.||.:     :|:.::.|.:.  ..|......|:.:...|..:...|.:
Human   663 SKLLVHHSFDLVIFHQMSSNI-----MEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNS 722

  Fly   556 --GSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKK 618
              ...|||.||......:.::.:          ..|.:..||          |:|..|.:    .
Human   723 IMVECLLLLGADANQAKEGSSLI----------CQVCEKESS----------PKLVELLL----N 763

  Fly   619 SQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAE 683
            |.||::||.:.:......|...:|.:
Human   764 SGSREQDVRKALTISIGKGDSQIISL--------------------------------------- 789

  Fly   684 TRSKIKLKVWKIPRFLKRFE-DLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETL 747
                          .|:|.. |:.|.|.|.|....|             |.|......|.|::|
Human   790 --------------LLRRLALDVANNSICLGGFCIG-------------KVEPSWLGPLFPDKT- 826

  Fly   748 AFMDNQMQNGNGCGYQQLPVLVESNHRTQT-LDIPAARPVLHHAATSTALASSVLRSPEAGVSGG 811
                                   ||.|.|| :....||.|:.:...|..         |.|.:.|
Human   827 -----------------------SNLRKQTNIASTLARMVIRYQMKSAV---------EEGTASG 859

  Fly   812 GGCCSPGQYSMYDDII---DVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEG 873
                |.|.:|  :|::   |..::|..|..| |.|.:|....|:                 |:||
Human   860 ----SDGNFS--EDVLSKFDEWTFIPDSSMD-SVFAQSDDLDSE-----------------GSEG 900

  Fly   874 RAGTSQTAPPVEQSPLPRPRASTLATG---------RPTPNSLEPGPSSTSPCCLPAPGNSVGGG 929
                         |.|.:.::::::.|         |.:||             |....||:  |
Human   901 -------------SFLVKKKSNSISVGEFYRDAVLQRCSPN-------------LQRHSNSL--G 937

  Fly   930 GIFPPTH----SRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSS 990
            .||  .|    .|:..|..|..|.:.|.::|:.|.|.        :.::::..|  .|.||...|
Human   938 PIF--DHEDLLKRKRKILSSDDSLRSSKLQSHMRHSD--------SISSLASER--EYITSLDLS 990

  Fly   991 ISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRK----QSDL-----QLIRCVR- 1045
            .:.|.::..|.            ...|       ::..|:.|.|    |:.|     ||...::
Human   991 ANELRDIDALS------------QKCC-------ISVHLEHLEKLELHQNALTSFPQQLCETLKS 1036

  Fly  1046 --------DNARSQRSYLVK--------------------------PPLRKFSLYF--------- 1067
                    :...|..|||:|                          |.|::|:|.:
Human  1037 LTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPEN 1101

  Fly  1068 -------------------------KSRQLERDFRSKAHRFG-AENETEGPPTLA--TPRYNTYI 1104
                                     :.::|:....||.|... :||..|..|.:.  :.|.|
Human  1102 LTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMN--- 1163

  Fly  1105 DIFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNR 1169
              |:....:|..|:::..::||.           |||..                 ::..|:.:
Human  1164 --FLAAMPFLPPSMTILKLSQNK-----------FSCIP-----------------EAILNLPH- 1197

  Fly  1170 FRSKSTTSEDLERDERGAAPGGRPHFESCADR----------IFEAISSWYPW------HICLAV 1218
            .||...:|.|::     ..| |..|::|...|          |.:.....|.|      |:....
Human  1198 LRSLDMSSNDIQ-----YLP-GPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNK 1256

  Fly  1219 LMAMPVLL-IIANFLLLDLE---QLEAF----------------EYHYGFLIFVCIVHFCNFTQL 1263
            |..:|..: .:.|...||:.   :|.:|                |.|..|          :|..:
Human  1257 LKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNF----------DFKHI 1311

  Fly  1264 NCWVRNVLAFL 1274
            .|..::::.||
Human  1312 GCKAKDIIRFL 1322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	54/287 (19%)
		Guanylate_cyc	361..535	CDD:278633	36/207 (17%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969		151/812 (19%)
		LRR 1	983..1004		6/32 (19%)
		leucine-rich repeat	985..1012	CDD:275380	7/45 (16%)
		LRR	1012..>1286	CDD:227223	54/313 (17%)
		LRR 2	1012..1033		6/20 (30%)
		leucine-rich repeat	1013..1036	CDD:275380	6/22 (27%)
		LRR 3	1036..1057		4/20 (20%)
		leucine-rich repeat	1037..1084	CDD:275380	5/46 (11%)
		LRR 4	1059..1080		0/20 (0%)
		LRR 5	1084..1105		3/20 (15%)
		leucine-rich repeat	1085..1108	CDD:275380	3/22 (14%)
		LRR 6	1108..1129		0/20 (0%)
		leucine-rich repeat	1109..1130	CDD:275380	0/20 (0%)
		LRR 7	1130..1150		6/19 (32%)
		leucine-rich repeat	1131..1174	CDD:275380	12/47 (26%)
		LRR 8	1174..1196		7/49 (14%)
		leucine-rich repeat	1175..1197	CDD:275380	6/49 (12%)
		LRR 9	1197..1218		7/27 (26%)
		leucine-rich repeat	1198..1221	CDD:275380	8/28 (29%)
		LRR 10	1221..1241		2/19 (11%)
		leucine-rich repeat	1222..1246	CDD:275380	4/23 (17%)
		LRR 11	1246..1267		3/20 (15%)
		leucine-rich repeat	1247..1269	CDD:275380	3/21 (14%)
		LRR 12	1269..1291		5/21 (24%)
		RocCOR	1334..1507	CDD:206741
		COR	1527..1740	CDD:318343
		STKc_LRRK2	1884..2135	CDD:270970
		WD 1	2139..2183
		WD 2	2188..2228
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900