Protein Alignment Ac13E and Adcy9

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_001400201.1
• Gene: Adcy9 / 11515
• MGIID: 108450
• Length: 1372
• Species: Mus musculus
• Alignment Length: 1720
• Identity: 512/1720 - (29%)
• Similarity: 745/1720 - (43%)
• Gaps: 567/1720 - (32%)

  Fly    57 LPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLYFVVDGGSED 121
            ||..||||::: |.||||||..|||......||..:.|:|:.|.|:....|:|.:||.|
Mouse    79 LPQLFERASSR-WWDPKFDSMNLEEACLERCFPQTQRRFRYALFYVGFACLLWSIYFAV------ 136

  Fly   122 FWRPISSSFSMLSLVTIM---ALC----------FTHWDLYREHRTVTSAVTALLLCGASLA--F 171
                     .|.|.|.:|   |||          ||...||..|...||....||:...:||  |
Mouse   137 ---------HMKSKVIVMVVPALCFLVVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQF 192

  Fly   172 LTYT---GR---------------AFSPLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFE 218
            ..:|   ||               ..|.:|.|:||:|::||:||.:.:||:|.....:.||:.||
Mouse   193 QVWTPLSGRVDSSNHTLTATPADTCLSQVGSFSICIEVLLLLYTVMQLPLYLSLFLGVVYSVLFE 257

  Fly   219 MVSHMVIG--CSAIHG-GPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNL 280
            ...:....  |....| |.:|..                   |:.|.:.|:.:|.:|:|:.:|:.
Mouse   258 TFGYHFRNEDCYPSPGPGALHWE-------------------LLSRALLHVCIHAIGIHLFVMSQ 303

  Fly   281 VRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDA----GGLPPES 341
            ||.|.||:||||:::..:.||:||.|||:|||||||..:||.|:.:|.....::    ....|::
Mouse   304 VRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKN 368

  Fly   342 HYMRPRASNDVKS--LFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLC 404
               |.:.|:..|:  .||||.|..:|.||||||||||||:||:.|:|..||.:|||||.|||.||
Mouse   369 ---RKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLC 430

  Fly   405 SLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTV 469
            ..:.||||||||||||||:||||||||||.||:|||||||.|:..|..::.|.|.||||||||||
Mouse   431 EQTKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTV 495

  Fly   470 LCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEG------------ 522
            ||||:|.||.|||||||||:|||.||..|...:||||:.|:.:|.|.|.:|:|
Mouse   496 LCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGRVIERLGQSVVA 560

  Fly   523 EEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPAS 587
            :::.|.:||.:.|:|           :..::.:.:..||.|            ...:..:...:.
Mouse   561 DQLKGLKTYLISGQR-----------AKESHCSCAEALLSG------------FEVIDDSRESSG 602

  Fly   588 PVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIII 652
            |.||.::|
Mouse   603 PRGQGTAS--------------------------------------------------------- 610

  Fly   653 TTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCG----G 713
                 |||: ||                .|:|              :|.|::|....|||    .
Mouse   611 -----PGSV-SD----------------LAQT--------------VKTFDNLKTCPSCGITFAP 639

  Fly   714 SSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNG---NGCGYQQLPVLVESNHRT 775
            .|.||                                   .:.|   |||  |..|
Mouse   640 KSEAG-----------------------------------AEGGTVQNGC--QDEP--------- 658

  Fly   776 QTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDI 840
                           .|||.:.||.|                             .::|
Mouse   659 ---------------KTSTKVTSSWL-----------------------------LFLS------ 673

  Fly   841 SPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPN 905
                                                     .|:...|   |:||
Mouse   674 -----------------------------------------VPLLAHP---PKAS---------- 684

  Fly   906 SLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSR----QSSICPSATSRKDSGIKSNSRRSSIQQQ 966
               .||:|.:.           .|.:.||...:    |:|:|..        ::...|.:.:
Mouse   685 ---GGPNSKTQ-----------NGLLSPPAEEKLTNSQTSLCEI--------LQEKGRWAGV--- 724

  Fly   967 IYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQ 1031
              :|:|:|:                          |||.                       .:.
Mouse   725 --SLDQSAL--------------------------LPLR-----------------------FKN 738

  Fly  1032 LRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPP--T 1094
            :|:::|...:..::::: ..:.|..|||:.:|||.|..::|||.:|:...    |...:..|  |
Mouse   739 IREKTDAHFVDVIKEDS-LMKDYFFKPPINQFSLNFLDQELERSYRTSYQ----EEVIKNSPVKT 798

  Fly  1095 LATPRYNTYIDIFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCR 1159
            .|:..:::.:|:|:...|:|.:|::.||....|.:|.....:.:|.....::|.:|.:..|.:
Mouse   799 FASATFSSLLDVFLSTTVFLILSITCFLKYGATATPPPPAALAVFGADLLLEVLSLIVSIRMV-- 861

  Fly  1160 RQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPV 1224
                           ...||:               .:|...:.|.|:.|.|.|...|:|:::|.
Mouse   862 ---------------FFLEDV---------------MTCTKWLLEWIAGWLPRHCIGAILVSLPA 896

  Fly  1225 LLIIANFLLLDLEQLEAFEYHY------GFLIFVCIVHFCNFTQLNCWVRNVLAF-----LAALC 1278
            |.:.::.       ...||.:.      |..:.|.:||:|||.||:.|:|:.||.     |..|.
Mouse   897 LAVYSHI-------TSEFETNIHVTMFTGSAVLVAVVHYCNFCQLSSWMRSSLATIVGAGLLLLL 954

  Fly  1279 FIGIAVSQLMVYSH--------------NRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILV 1329
            .|.:.....:|.|.              |.|..|..:..::.|.:         |:.|...|:|:
Mouse   955 HISLCQDSSIVMSPLDSAQNFSAQRNPCNSSVLQDGRRPASLIGK---------ELILTFFLLLL 1010

  Fly  1330 LVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTAKYSENHHN 1394
            ||||||||||:.|||.::|:..|:..:.::|:|::|||.||.||||.||||.||.:..||:||.:
Mouse  1011 LVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDS 1075

  Fly  1395 IAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLD 1459
            ..:||||||||:|.|:|:|.||||..|||||||||||||||:|::.::|||||||:|:||||||:
Mouse  1076 GGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNSIEKIKTIGATYMAASGLN 1140

  Fly  1460 PS---HRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDI 1521
            .:   ..|...||:..|.||:..|..|||.||.::|.||..||:|.|.|.:|||||||:||.|||
Mouse  1141 TAQCQEGGHPQEHLRILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDI 1205

  Fly  1522 WGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNR-YEFEPRGSVYVKGKDHMEVFLYTTRRDNPL- 1584
            |||.||:|||||:||:..||||.::....|:.. |:|:.||:|.||||..|:.:||....||.:
Mouse  1206 WGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDNGVV 1270

  Fly  1585 -----------------------DDDEADKVEQLGTKKMEHEGRDEDVVQGEQQAEDKDEEEE-- 1624
                                   .|:.|:.|..:........|.|:.....|.:...|....|
Mouse  1271 PQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYSDKASLGSDDSTQAKEARLSSKRSWREPV 1335

  Fly  1625 ------------EEEEDDDLHSSETTTLFK 1642
                        |::..:|:...|.:.|.|
Mouse  1336 KAEERFPFGKAIEKDSCEDIGVEEASELSK 1365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	130/221 (59%)
		PHA03307	836..>1015	CDD:223039	21/182 (12%)
		Guanylate_cyc	1388..1575	CDD:425528	109/190 (57%)
Adcy9	NP_001400201.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..73
		AcyC	167..576	CDD:441717	190/441 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..375		4/28 (14%)
		Guanylate_cyc	385..573	CDD:425528	113/187 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..615		7/81 (9%)
		Guanylate_cyc	1069..1260	CDD:425528	109/190 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1309..1333		4/23 (17%)