Protein Alignment Ac13E and ADCY9

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_005255136.1
• Gene: ADCY9 / 115
• HGNCID: 240
• Length: 1372
• Species: Homo sapiens
• Alignment Length: 1622
• Identity: 492/1622 - (30%)
• Similarity: 714/1622 - (44%)
• Gaps: 529/1622 - (32%)

  Fly    57 LPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLYFVVDGGSED 121
            ||..||||::: |.||||||..|||......||..:.|:|:.|.||....|:|.:||.|
Human    79 LPQLFERASSR-WWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAV------ 136

  Fly   122 FWRPISSSFSMLSLVTIM---ALC----------FTHWDLYREHRTVTSAVTALLLCGASLAF-- 171
                     .|.|.:.:|   |||          ||...||..|...||....||:...:||.
Human   137 ---------HMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQF 192

  Fly   172 --------------LTYTGR----AFSPLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFE 218
                          ||.|.|    ..|.:|.|::|:|::.|:||.:.:||:|.....::||:.||
Human   193 QVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFE 257

  Fly   219 MVSHMV--------IGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHV 275
            ...:..        .|..|:|..                        |:.|.:.|..:|.:|||:
Human   258 TFGYHFRDEACFPSPGAGALHWE------------------------LLSRGLLHGCIHAIGVHL 298

  Fly   276 LIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDA----GG 336
            .:|:.||.|.||:||||:::..:.||:||.|||:|||||||..:||.|:.:|.....::    ..
Human   299 FVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHAT 363

  Fly   337 LPPESHYMRPRASNDVKS--LFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFER 399
            ..|::   |.:.|:..|:  .||||.|..:|.||||||||||||:||:.|:|..||.:|||||.|
Human   364 SSPKN---RKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGR 425

  Fly   400 FDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGV 464
            ||.||..:.||||||||||||||:||||||||||.||:|||||||.|:..|..::.|.|.|||||
Human   426 FDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGV 490

  Fly   465 HTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEG------- 522
            |||||||||:|.||.|||||||||:|||.||..|...:||||:.|:.:|.|.|.:|:|
Human   491 HTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLG 555

  Fly   523 -----EEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPN 582
                 :::.|.:||.:.|:|...:|.:.           :..||.|......||.:
Human   556 QSVVADQLKGLKTYLISGQRAKESRCSC-----------AEALLSGFEVIDGSQVS--------- 600

  Fly   583 VPPASPVGQ-LSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRE 646
               :.|.|| .:||.|.|.:
Human   601 ---SGPRGQGTASSGNVSDL--------------------------------------------- 617

  Fly   647 RPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSC 711
                                               |:|              :|.|::|....||
Human   618 -----------------------------------AQT--------------VKTFDNLKTCPSC 633

  Fly   712 G----GSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNG---NGCGYQQLPVLV 769
            |    ..|.||                                   .:.|   |||
Human   634 GITFAPKSEAG-----------------------------------AEGGAPQNGC--------- 654

  Fly   770 ESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYIS 834
            :..|:..|           ...:|..|..||
Human   655 QDEHKNST-----------KVTSSWLLFLSV---------------------------------- 674

  Fly   835 QSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLAT 899
                                                            |:...|   |:||
Human   675 ------------------------------------------------PLLAHP---PKAS---- 684

  Fly   900 GRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSR----QSSICPSATSRKDSGIKSNSRR 960
            |.|.|.:                    ..|.:.||...:    |:|:|..        ::...|.
Human   685 GGPNPKT--------------------QNGLLSPPQEEKLTNSQTSLCEI--------LQEKGRW 721

  Fly   961 SSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPL 1025
            :.:     :|:|:|:                          |||.
Human   722 AGV-----SLDQSAL--------------------------LPLR-------------------- 735

  Fly  1026 AACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETE 1090
               .:.:|:::|...:..::::: ..:.|..|||:.:|||.|..::|||.:|:...    |...:
Human   736 ---FKNIREKTDAHFVDVIKEDS-LMKDYFFKPPINQFSLNFLDQELERSYRTSYQ----EEVIK 792

  Fly  1091 GPP--TLATPRYNTYIDIFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLF 1153
            ..|  |.|:|.:::.:|:|:...|:|.:|.:.||..:....|.....:.:||....::|.:|.:.
Human   793 NSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVS 857

  Fly  1154 TRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAV 1218
            .|.:                 ...||:               .:|..|:.|.|:.|.|.|...|:
Human   858 IRMV-----------------FFLEDV---------------MACTKRLLEWIAGWLPRHCIGAI 890

  Fly  1219 LMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAA-----LC 1278
            |:::|.|.:.:: :..:.|....|....|....:.:||:|||.||:.|:|:.||.:..     |.
Human   891 LVSLPALAVYSH-VTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLL 954

  Fly  1279 FIGIAVSQLMVYS-----HNRSDQQQDQEAS---------NFIQEIKWFQDYHVEIYLDLLLILV 1329
            ::.:.....::.|     .|.|.::....:|         :.|.:         |:.|...|:|:
Human   955 YVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQ---------EVVLVFFLLLL 1010

  Fly  1330 LVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTAKYSENHHN 1394
            ||||||||||:.|||.::|:..|:..:.::|:|::|||.||.||||.||||.||.:..||:||.:
Human  1011 LVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDS 1075

  Fly  1395 IAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLD 1459
            ..:||||||||:|.|:|:|.||||..|||||||||||||||:|::.::|||||||:|:||||||:
Human  1076 GGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLN 1140

  Fly  1460 PSHRGTG---DEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDI 1521
            .:....|   .||:..|.||:..|..|||.||.::|.||..||:|.|.|.:|||||||:||.|||
Human  1141 TAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDI 1205

  Fly  1522 WGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNR-YEFEPRGSVYVKGKDHMEVFLYTTRRDN 1582
            |||.||:|||||:||:..||||.::....|:.. |:|:.||:|.||||..|:.:||....|:
Human  1206 WGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDH 1267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	130/221 (59%)
		PHA03307	836..>1015	CDD:223039	21/182 (12%)
		Guanylate_cyc	1388..1575	CDD:425528	109/190 (57%)
ADCY9	XP_005255136.1	AcyC	167..576	CDD:441717	187/435 (43%)
		Guanylate_cyc	385..573	CDD:425528	113/187 (60%)
		Guanylate_cyc	1069..1260	CDD:425528	109/190 (57%)