DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ac13E and ADCY9

DIOPT Version :9

Sequence 1:NP_001259575.1 Gene:Ac13E / 32485 FlyBaseID:FBgn0022710 Length:1703 Species:Drosophila melanogaster
Sequence 2:XP_005255136.1 Gene:ADCY9 / 115 HGNCID:240 Length:1372 Species:Homo sapiens


Alignment Length:1622 Identity:492/1622 - (30%)
Similarity:714/1622 - (44%) Gaps:529/1622 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 LPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLYFVVDGGSED 121
            ||..||||::: |.||||||..|||......||..:.|:|:.|.||....|:|.:||.|      
Human    79 LPQLFERASSR-WWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAV------ 136

  Fly   122 FWRPISSSFSMLSLVTIM---ALC----------FTHWDLYREHRTVTSAVTALLLCGASLAF-- 171
                     .|.|.:.:|   |||          ||...||..|...||....||:...:||.  
Human   137 ---------HMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQF 192

  Fly   172 --------------LTYTGR----AFSPLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFE 218
                          ||.|.|    ..|.:|.|::|:|::.|:||.:.:||:|.....::||:.||
Human   193 QVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFE 257

  Fly   219 MVSHMV--------IGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHV 275
            ...:..        .|..|:|..                        |:.|.:.|..:|.:|||:
Human   258 TFGYHFRDEACFPSPGAGALHWE------------------------LLSRGLLHGCIHAIGVHL 298

  Fly   276 LIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDA----GG 336
            .:|:.||.|.||:||||:::..:.||:||.|||:|||||||..:||.|:.:|.....::    ..
Human   299 FVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHAT 363

  Fly   337 LPPESHYMRPRASNDVKS--LFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFER 399
            ..|::   |.:.|:..|:  .||||.|..:|.||||||||||||:||:.|:|..||.:|||||.|
Human   364 SSPKN---RKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGR 425

  Fly   400 FDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGV 464
            ||.||..:.||||||||||||||:||||||||||.||:|||||||.|:..|..::.|.|.|||||
Human   426 FDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGV 490

  Fly   465 HTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEG------- 522
            |||||||||:|.||.|||||||||:|||.||..|...:||||:.|:.:|.|.|.:|:|       
Human   491 HTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLG 555

  Fly   523 -----EEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPN 582
                 :::.|.:||.:.|:|...:|.:.           :..||.|......||.:         
Human   556 QSVVADQLKGLKTYLISGQRAKESRCSC-----------AEALLSGFEVIDGSQVS--------- 600

  Fly   583 VPPASPVGQ-LSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRE 646
               :.|.|| .:||.|.|.:                                             
Human   601 ---SGPRGQGTASSGNVSDL--------------------------------------------- 617

  Fly   647 RPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSC 711
                                               |:|              :|.|::|....||
Human   618 -----------------------------------AQT--------------VKTFDNLKTCPSC 633

  Fly   712 G----GSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNG---NGCGYQQLPVLV 769
            |    ..|.||                                   .:.|   |||         
Human   634 GITFAPKSEAG-----------------------------------AEGGAPQNGC--------- 654

  Fly   770 ESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYIS 834
            :..|:..|           ...:|..|..||                                  
Human   655 QDEHKNST-----------KVTSSWLLFLSV---------------------------------- 674

  Fly   835 QSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLAT 899
                                                            |:...|   |:||    
Human   675 ------------------------------------------------PLLAHP---PKAS---- 684

  Fly   900 GRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSR----QSSICPSATSRKDSGIKSNSRR 960
            |.|.|.:                    ..|.:.||...:    |:|:|..        ::...|.
Human   685 GGPNPKT--------------------QNGLLSPPQEEKLTNSQTSLCEI--------LQEKGRW 721

  Fly   961 SSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPL 1025
            :.:     :|:|:|:                          |||.                    
Human   722 AGV-----SLDQSAL--------------------------LPLR-------------------- 735

  Fly  1026 AACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETE 1090
               .:.:|:::|...:..::::: ..:.|..|||:.:|||.|..::|||.:|:...    |...:
Human   736 ---FKNIREKTDAHFVDVIKEDS-LMKDYFFKPPINQFSLNFLDQELERSYRTSYQ----EEVIK 792

  Fly  1091 GPP--TLATPRYNTYIDIFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLF 1153
            ..|  |.|:|.:::.:|:|:...|:|.:|.:.||..:....|.....:.:||....::|.:|.:.
Human   793 NSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVS 857

  Fly  1154 TRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAV 1218
            .|.:                 ...||:               .:|..|:.|.|:.|.|.|...|:
Human   858 IRMV-----------------FFLEDV---------------MACTKRLLEWIAGWLPRHCIGAI 890

  Fly  1219 LMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAA-----LC 1278
            |:::|.|.:.:: :..:.|....|....|....:.:||:|||.||:.|:|:.||.:..     |.
Human   891 LVSLPALAVYSH-VTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLL 954

  Fly  1279 FIGIAVSQLMVYS-----HNRSDQQQDQEAS---------NFIQEIKWFQDYHVEIYLDLLLILV 1329
            ::.:.....::.|     .|.|.::....:|         :.|.:         |:.|...|:|:
Human   955 YVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQ---------EVVLVFFLLLL 1010

  Fly  1330 LVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTAKYSENHHN 1394
            ||||||||||:.|||.::|:..|:..:.::|:|::|||.||.||||.||||.||.:..||:||.:
Human  1011 LVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDS 1075

  Fly  1395 IAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLD 1459
            ..:||||||||:|.|:|:|.||||..|||||||||||||||:|::.::|||||||:|:||||||:
Human  1076 GGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLN 1140

  Fly  1460 PSHRGTG---DEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDI 1521
            .:....|   .||:..|.||:..|..|||.||.::|.||..||:|.|.|.:|||||||:||.|||
Human  1141 TAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDI 1205

  Fly  1522 WGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNR-YEFEPRGSVYVKGKDHMEVFLYTTRRDN 1582
            |||.||:|||||:||:..||||.::....|:.. |:|:.||:|.||||..|:.:||....|:
Human  1206 WGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDH 1267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac13ENP_001259575.1 CYCc 302..518 CDD:214485 130/221 (59%)
Guanylate_cyc 361..535 CDD:278633 112/185 (61%)
CYCc 1362..1556 CDD:214485 115/197 (58%)
Guanylate_cyc 1388..1575 CDD:278633 109/190 (57%)
ADCY9XP_005255136.1 DUF2339 <118..>301 CDD:287113 54/221 (24%)
CYCc 326..544 CDD:214485 130/220 (59%)
Guanylate_cyc 385..573 CDD:278633 113/187 (60%)
CYCc 1043..1243 CDD:214485 116/199 (58%)
Guanylate_cyc 1069..1260 CDD:278633 109/190 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158664
Domainoid 1 1.000 228 1.000 Domainoid score I2503
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H868
Inparanoid 1 1.050 736 1.000 Inparanoid score I600
Isobase 1 0.950 - 0 Normalized mean entropy S6595
OMA 1 1.010 - - QHG49383
OrthoDB 1 1.010 - - D207369at33208
OrthoFinder 1 1.000 - - FOG0006877
OrthoInspector 1 1.000 - - oto89215
orthoMCL 1 0.900 - - OOG6_106616
Panther 1 1.100 - - LDO PTHR45627
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3771
SonicParanoid 1 1.000 - - X5766
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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